Results 71 to 80 of about 176,030 (314)

Impaired Muscle Regeneration in Ob/ob and Db/db Mice

The Scientific World Journal, 2011
In obesity and type 2 diabetes, efficient skeletal muscle repair following injury may be required, not only for restoring muscle structure and function, but also for maintaining exercise capacity and insulin sensitivity.
Mai-Huong Nguyen, Ming Cheng, Timothy J. Koh   +2 more
doaj   +1 more source

Myo-REG: A Portal for Signaling Interactions in Muscle Regeneration

Frontiers in Physiology, 2019
Muscle regeneration is a complex process governed by the interplay between several muscle-resident mononuclear cell populations. Following acute or chronic damage these cell populations are activated, communicate via cell–cell interactions and/or ...
Alessandro Palma, Andrea Cerquone Perpetuini, Federica Ferrentino, Claudia Fuoco, Cesare Gargioli, Giulio Giuliani, Marta Iannuccelli, Luana Licata, Elisa Micarelli, Serena Paoluzi, Livia Perfetto, Lucia Lisa Petrilli, Alessio Reggio, Marco Rosina, Francesca Sacco, Simone Vumbaca, Alessandro Zuccotti, Luisa Castagnoli, Gianni Cesareni, Gianni Cesareni   +19 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Modulation of Caspase Activity in Muscle Stem Cells Regulates Muscle Regeneration and Function [PDF]

, 2009
Muscle homeostasis involves de novo myogenesis, as observed in conditions of acute or chronic muscle damage. Tumor Necrosis Factor (TNF) triggers skeletal muscle wasting and inhibits muscle regeneration.
MORESI, Viviana, RIZZUTO, EMANUELE, GARCIA ALVAREZ G, SASSOON D, ROCCHI M, ALBERTINI MC, COLETTI, Dario, ADAMO, Sergio   +7 more
core  

CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production [PDF]

, 2015
International audienceMuscle injury triggers inflammation in which infiltrating mononuclear phagocytes are crucial for tissue regeneration. The interaction of the CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axis that guides phagocyte infiltration is ...
Boissonnas A., Saclier M., Chazaud, Bénédicte, Benhabiles N., Arnold, Ludovic, Guyon, Elodie, Mounier R., Saclier, Marielle, de Chanville, Camille Baudesson, Hermand, Patricia, Perrin H., Boissonnas, Alexandre, Combadiere C., Perrin, Hélène, Poupel L., Benhabiles, Nora, Combadiere, Christophe, Combadiere, Béhazine, Arnold L., Carpentier W., Hermand P., Carpentier, Wassila, Guyon E., Licata F., Licata, Fabrice, Chazaud B., Poupel, Lucie, Mounier, Rémi, Vilar J., Combadiere B., De Chanville C. B., Vilar, José   +31 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells

, 2016
The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and ...
Pinheiro, Carlos Hermano J., Lucas Guimaraes-Ferreira, Carlos Hermano J. Pinheiro, Ferreira, Lucas Guimarães   +3 more
core   +1 more source

Strain‐Programmable Luminescent Adhesive Patch With Tartrazine‐Mediated Optical Skin Clearing for Photochemical Tissue Bonding

Advanced Functional Materials, EarlyView.
We propose a suture‐complementary approach that integrates optical skin clearing with a strain‐programmable luminescent adhesive patch. Hyaluronic acid promotes transdermal delivery of tartrazine to improve optical clearing and stabilizes its interaction with a photosensitizer. Optical clearing increases the penetration depth of visible light into skin,
Seong‐Jong Kim, Kyungjoo Jo, Kwanghyeon Park, Jun Hee Kim, Jong Hyeong Cho, Inhoo Choi, Sei Kwang Hahn   +6 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source