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Muscle stem cells

Current Opinion in Cell Biology, 2009
Despite being mainly composed of highly differentiated contractile fibers, the adult skeletal muscle possesses the remarkable ability to regenerate, following injury. The cells that are responsible for this capacity are the satellite cells, a small population of adult stem cells positioned under the basal lamina of muscle fibers and that can give rise ...
Frédéric, Relaix, Christophe, Marcelle
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Muscling in on stem cells

Biology of the Cell, 2006
Skeletal muscle is one of the few adult tissues that possesses the capacity for regeneration (restoration of lost functional tissue) as opposed to repair. This capacity is due to the presence of ‘muscle stem cells’ known as satellite cells. Detailed investigation of these cells over the past 50 years has revealed that both these and other cells within ...
Andrea C M, Sinanan   +2 more
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Muscle stem cells

The Journal of Pathology, 2002
AbstractSince its discovery four decades ago, the satellite cell of skeletal muscle has been implicated as the major source of myogenic cells involved in growth and repair of muscle fibres. This review not only looks at the role of the satellite cell in these processes but discusses how cells derived from other sources and tissues have recently been ...
Kirstin, Goldring   +2 more
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Skeletal muscle stem cells

Current Opinion in Genetics & Development, 2008
In this review we shall discuss recent publications on the heterogeneity of muscle stem cells, signaling pathways that affect their behaviour and regulatory mechanisms that underlie their myogenic fate, with reference to insights provided by work on skeletal muscle formation in the embryo as well as the adult, with the mouse as a model of reference.
Margaret, Buckingham, Didier, Montarras
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Muscle Stem Cell Immunostaining

Current Protocols in Mouse Biology, 2018
AbstractMuscle stem cells (MuSCs) are essential for maintaining muscle homeostasis by providing progenitor cells for muscle regeneration after injury and in muscular diseases. MuSC properties dynamically change, reflecting physiology or pathological status.
Shuaiyu, Wang   +5 more
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Human muscle stem cells

Current Opinion in Pharmacology, 2006
Stem cells are unspecialized cells that have been defined in many different ways but they have two important characteristics that distinguish them from other cells in the body. First, they can replenish their numbers for long periods through cell division.
Racquel N, Cooper   +2 more
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The muscle stem cell niche at a glance

Journal of Cell Science, 2023
ABSTRACT Skeletal muscle stem cells (MuSCs, also called satellite cells) are the source of the robust regenerative capability of this tissue. The hallmark property of MuSCs at homeostasis is quiescence, a reversible state of cell cycle arrest required for long-term preservation of the stem cell population.
Margaret Hung   +3 more
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Skeletal Muscle Stem Cells

2013
Skeletal muscle satellite cells (myoblasts) are the primary stem cells of skeletal muscle which contribute to growth, maintenance, and repair of the muscles. Satellite cells are the first stem cells used for cellular cardiomyoplasty more than 20 years ago.
Kao, Grace W.   +2 more
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Muscle stem cells on the edge

Current Opinion in Genetics & Development, 2015
Release of muscle stem cells from quiescence involves the coordinated effort of transcription, mRNA stability, and translation. We focus this review on post-transcriptional regulation of muscle stem cells and highlight the impact of deregulated mRNA homeostasis on muscle aging and muscle disease pathogenesis.
Jason D Doles, Bradley B Olwin
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Stem Cells and Muscle Diseases

Journal of Muscle Research & Cell Motility, 2004
In the past recent years, basic science work and initial clinical trials have provided starting evidence that stem cells are of potential value for treatment of certain human diseases, where they could help to regenerate tissues which are defective because of either genetic or acquired diseases.
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