Results 1 to 10 of about 256,968 (162)

Skeletal muscle stem cells [PDF]

Reproductive Biology and Endocrinology, 2003
Satellite cells are myogenic stem cells responsible for the post-natal growth, repair and maintenance of skeletal muscle. This review focuses on the basic biology of the satellite cell with emphasis on its role in muscle repair and parallels between ...
Goldhamer David J, Chen Jennifer CJ
doaj   +3 more sources

Single-Cell Analysis of the Muscle Stem Cell Hierarchy Identifies Heterotypic Communication Signals Involved in Skeletal Muscle Regeneration

Cell Reports, 2020
Summary: Muscle regeneration relies on the regulation of muscle stem cells (MuSCs) through paracrine signaling interactions. We analyzed muscle regeneration in mice using single-cell RNA sequencing (scRNA-seq) and generated over 34,000 single-cell ...
Andrea J. De Micheli, Emily J. Laurilliard, Charles L. Heinke, Hiranmayi Ravichandran, Paula Fraczek, Sharon Soueid-Baumgarten, Iwijn De Vlaminck, Olivier Elemento, Benjamin D. Cosgrove   +8 more
doaj   +3 more sources

Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

Nature Communications, 2018
The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired ...
Srinath C. Sampath, Srihari C. Sampath, Andrew T. V. Ho, Stéphane Y. Corbel, Joshua D. Millstone, John Lamb, John Walker, Bernd Kinzel, Christian Schmedt, Helen M. Blau   +9 more
doaj   +2 more sources

Muscle Stem Cell Microenvironment and Functions in Muscle Regeneration. [PDF]

Biomolecules
Muscle stem cells (MuSCs) are the key to muscle regeneration. The activation and maintenance of MuSCs require the precise regulation of their microenvironments. Myofibers and other cells including endothelial cells, fibroblasts, and immune cell populations constitute the cell components of the MuSC niche.
Li W, Chen M, Zhang L.
europepmc   +4 more sources

The muscle stem cell niche at a glance.

J Cell Sci, 2023
ABSTRACT Skeletal muscle stem cells (MuSCs, also called satellite cells) are the source of the robust regenerative capability of this tissue. The hallmark property of MuSCs at homeostasis is quiescence, a reversible state of cell cycle arrest required for long-term preservation of the stem cell population.
Hung M, Lo HF, Jones GEL, Krauss RS.
europepmc   +3 more sources

REST/NRSF Preserves muscle stem cell identity by repressing alternate cell fate [PDF]

Nature Communications
Cell fate and identity require timely activation of lineage-specific and concomitant repression of alternate-lineage genes. How this process is epigenetically encoded remains largely unknown. In skeletal muscle stem cells, the myogenic regulatory factors
Korin Sahinyan, Darren M. Blackburn, Marie-Michelle Simon, Felicia Lazure, Tony Kwan, David H. Wilson, Maryam Vahidyeganeh, Nawal Alsadi, Julia von Maltzahn, Yasuhiro Yamada, Arezu Jahani-Asl, Guillaume Bourque, Michael A. Rudnicki, Vahab D. Soleimani   +13 more
doaj   +2 more sources

Exercise/Resistance Training and Muscle Stem Cells [PDF]

Endocrinology and Metabolism, 2021
Skeletal muscle has attracted attention as endocrine organ, because exercise-dependent cytokines called myokines/exerkines are released from skeletal muscle and are involved in systemic functions.
So-ichiro Fukada, Ayasa Nakamura
doaj   +1 more source

Vitamin A retinoic acid contributes to muscle stem cell and mitochondrial function loss in old age [PDF]

JCI Insight
Adult stem cells decline in number and function in old age, and identifying factors that can delay or revert age-associated adult stem cell dysfunction are vital for maintaining a healthy lifespan.
Paula M. Fraczek, Pamela Duran, Benjamin A. Yang, Valeria Ferre, Leanne Alawieh, Jesus A. Castor-Macias, Vivian T. Wong, Steve D. Guzman, Celeste Piotto, Klimentini Itsani, Jacqueline A. Larouche, Carlos A. Aguilar   +11 more
doaj   +2 more sources

Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration

Skeletal Muscle, 2022
Skeletal muscle homeostasis and function are ensured by orchestrated cellular interactions among several types of cells. A noticeable aspect of skeletal muscle biology is the drastic cell–cell communication changes that occur in multiple scenarios.
So-ichiro Fukada, Tatsuyoshi Higashimoto, Akihiro Kaneshige   +2 more
doaj   +1 more source

Muscle stem cells [PDF]

Current Biology, 2018
Feige and Rudnicki introduce muscle stem cells.
Peter, Feige, Michael A, Rudnicki
openaire   +2 more sources