Results 1 to 10 of about 488,075 (260)

The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development [PDF]

Frontiers in Aging Neuroscience, 2015
Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem ...
Julia eMeireles Nogueira, Julia eMeireles Nogueira, Katarzyna eHawrot, Colin eSharpe, Anna eNoble, William M. Wood, Erika C. Jorge, David J. Goldhamer, Gabrielle eKardon, Susanne eDietrich   +9 more
doaj   +4 more sources

Molecular Regulation and Rejuvenation of Muscle Stem (Satellite) Cell Aging [PDF]

Indonesian Biomedical Journal, 2015
BACKGROUND: Age-related muscle loss leads to lack of muscle strength, resulting in reduced posture and mobility and an increased risk of falls, all of which contribute to a decrease in quality of life.
Anna Meiliana, Nurrani Mustika Dewi, Andi Wijaya   +2 more
doaj   +5 more sources

Loss of Ptpn11 (Shp2) drives satellite cells into quiescence [PDF]

eLife, 2017
The equilibrium between proliferation and quiescence of myogenic progenitor and stem cells is tightly regulated to ensure appropriate skeletal muscle growth and repair.
Joscha Griger, Robin Schneider, Ines Lahmann, Verena Schöwel, Charles Keller, Simone Spuler, Marc Nazare, Carmen Birchmeier   +7 more
doaj   +5 more sources

Exercise/Resistance Training and Muscle Stem Cells [PDF]

Endocrinology and Metabolism, 2021
Skeletal muscle has attracted attention as endocrine organ, because exercise-dependent cytokines called myokines/exerkines are released from skeletal muscle and are involved in systemic functions.
So-ichiro Fukada, Ayasa Nakamura
doaj   +1 more source

Vitamin A retinoic acid contributes to muscle stem cell and mitochondrial function loss in old age [PDF]

JCI Insight
Adult stem cells decline in number and function in old age, and identifying factors that can delay or revert age-associated adult stem cell dysfunction are vital for maintaining a healthy lifespan.
Paula M. Fraczek, Pamela Duran, Benjamin A. Yang, Valeria Ferre, Leanne Alawieh, Jesus A. Castor-Macias, Vivian T. Wong, Steve D. Guzman, Celeste Piotto, Klimentini Itsani, Jacqueline A. Larouche, Carlos A. Aguilar   +11 more
doaj   +2 more sources

Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration

Skeletal Muscle, 2022
Skeletal muscle homeostasis and function are ensured by orchestrated cellular interactions among several types of cells. A noticeable aspect of skeletal muscle biology is the drastic cell–cell communication changes that occur in multiple scenarios.
So-ichiro Fukada, Tatsuyoshi Higashimoto, Akihiro Kaneshige   +2 more
doaj   +1 more source

GLI3 regulates muscle stem cell entry into GAlert and self-renewal

Nature Communications, 2022
Primary cilia regulate the processing of the GLI transcription factors and Hedgehog signaling. Here, the authors show that cilia-related GLI3 controls both the quiescence-to-activation transition and self-renewal in muscle stem cells.
Caroline E. Brun, Marie-Claude Sincennes, Alexander Y. T. Lin, Derek Hall, William Jarassier, Peter Feige, Fabien Le Grand, Michael A. Rudnicki   +7 more
doaj   +1 more source

Detection of muscle stem cell-derived myonuclei in murine overloaded muscles

STAR Protocols, 2022
Summary: Muscle satellite cells (MuSCs) supply nuclei to existing myofibers in response to mechanical loading. This myonuclear accretion is critical for efficient muscle hypertrophy.
Akihiro Kaneshige, Takayuki Kaji, Hayato Saito, Tatsuyoshi Higashimoto, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi, So-ichiro Fukada   +8 more
doaj   +1 more source

Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging

Nature Communications, 2022
Repair of muscle damage requires muscle stem cells, which lose regenerative capacity with aging. Here, the authors show that a sensory organelle, the primary cilium, is critical for muscle stem cell proliferation during regeneration and lost with aging.
Adelaida R. Palla, Keren I. Hilgendorf, Ann V. Yang, Jaclyn P. Kerr, Aaron C. Hinken, Janos Demeter, Peggy Kraft, Nancie A. Mooney, Nora Yucel, David M. Burns, Yu Xin Wang, Peter K. Jackson, Helen M. Blau   +12 more
doaj   +1 more source

Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA

Nature Communications, 2020
Alphaviruses need to selectively package genomic viral RNA for transmission, but the packaging mechanism remains unclear. Here, Brown et al. combine PAR-CLIP with biotinylated capsid protein (Cp) retrieval and identify multiple Cp binding sites on ...
Rebecca S. Brown, Dimitrios G. Anastasakis, Markus Hafner, Margaret Kielian   +3 more
doaj   +1 more source