Results 21 to 30 of about 1,407,681 (347)

Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche

Frontiers in Cell and Developmental Biology, 2022
The extracellular matrix (ECM) is an interconnected macromolecular scaffold occupying the space between cells. Amongst other functions, the ECM provides structural support to tissues and serves as a microenvironmental niche that conveys regulatory ...
S. C. Schüler, Yuguo Liu, Simon Dumontier, M. Grandbois, Emmeran Le Moal, D. Cornelison, C. Bentzinger   +6 more
semanticscholar   +1 more source

Assessing Autophagy in Muscle Stem Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
The skeletal muscle tissue in the adult is relatively stable under normal conditions but retains a striking ability to regenerate by its resident stem cells (satellite cells). Satellite cells exist in a quiescent (G0) state; however, in response to an injury, they reenter the cell cycle and start proliferating to provide sufficient progeny to form new ...
Silvia Campanario, Silvia Campanario, Ignacio Ramírez-Pardo, Ignacio Ramírez-Pardo, Xiaotong Hong, Xiaotong Hong, Joan Isern, Joan Isern, Pura Muñoz-Cánoves, Pura Muñoz-Cánoves, Pura Muñoz-Cánoves   +10 more
openaire   +6 more sources

Detection of muscle stem cell-derived myonuclei in murine overloaded muscles

STAR Protocols, 2022
Summary: Muscle satellite cells (MuSCs) supply nuclei to existing myofibers in response to mechanical loading. This myonuclear accretion is critical for efficient muscle hypertrophy.
Akihiro Kaneshige, Takayuki Kaji, Hayato Saito, Tatsuyoshi Higashimoto, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi, So-ichiro Fukada   +8 more
doaj   +1 more source

Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice

Nature Communications, 2021
Muscle stem cell function has been suggested to be regulated by Acetyl-CoA and NAD+ availability, but the mechanisms remain unclear. Here we report the identification of two acetylation sites on PAX7 that positively regulate its transcriptional activity.
Marie-Claude Sincennes, Caroline E. Brun, A. Lin, Tabitha Rosembert, David Datzkiw, J. Saber, Hong Ming, Yoh‐ichi Kawabe, M. Rudnicki   +8 more
semanticscholar   +1 more source

Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging

Nature Communications, 2022
Repair of muscle damage requires muscle stem cells, which lose regenerative capacity with aging. Here, the authors show that a sensory organelle, the primary cilium, is critical for muscle stem cell proliferation during regeneration and lost with aging.
Adelaida R. Palla, Keren I. Hilgendorf, Ann V. Yang, Jaclyn P. Kerr, Aaron C. Hinken, Janos Demeter, Peggy Kraft, Nancie A. Mooney, Nora Yucel, David M. Burns, Yu Xin Wang, Peter K. Jackson, Helen M. Blau   +12 more
doaj   +1 more source

The Potential of Muscle Stem Cells [PDF]

Developmental Cell, 2001
Skeletal muscle contains two types of stem cells: satellite cells, which function as myogenic precursors, and a population of multipotent adult stem cells. Satellite cells are believed to form a stable, self-renewing pool of stem cells in adult muscle where they function in tissue growth and repair.
Seale, Patrick, Asakura, Atsushi, Rudnicki, Michael A.   +2 more
openaire   +2 more sources

Neutrophil and natural killer cell imbalances prevent muscle stem cell–mediated regeneration following murine volumetric muscle loss

bioRxiv, 2021
Volumetric muscle loss (VML) overwhelms the innate regenerative capacity of mammalian skeletal muscle (SkM), leading to numerous disabilities and reduced quality of life.
Jacqueline A. Larouche, Sarah J. Kurpiers, Benjamin A. Yang, C. Davis, P. Fraczek, Matthew S. Hall, S. Brooks, L. Shea, C. A. Aguilar   +8 more
semanticscholar   +1 more source

Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA

Nature Communications, 2020
Alphaviruses need to selectively package genomic viral RNA for transmission, but the packaging mechanism remains unclear. Here, Brown et al. combine PAR-CLIP with biotinylated capsid protein (Cp) retrieval and identify multiple Cp binding sites on ...
Rebecca S. Brown, Dimitrios G. Anastasakis, Markus Hafner, Margaret Kielian   +3 more
doaj   +1 more source

METTL3-Mediated m6A Methylation Regulates Muscle Stem Cells and Muscle Regeneration by Notch Signaling Pathway

Stem Cells International, 2021
The Pax7+ muscle stem cells (MuSCs) are essential for skeletal muscle homeostasis and muscle regeneration upon injury, while the molecular mechanisms underlying muscle stem cell fate determination and muscle regeneration are still not fully understood ...
Yu Liang, Hui Han, Qiuchan Xiong, Chunlong Yang, Lu Wang, Jieyi Ma, Shuibin Lin, Yi-Zhou Jiang   +7 more
doaj   +1 more source

Muscle-derived stem cells [PDF]

Gene Therapy, 2002
The existence of cells with stem cell-like abilities derived from various tissues can now be extended to include the skeletal muscle compartment. Although researchers have focused on the utilization of these cells with regard to their myogenic capacity, initially exploring more efficient cellular therapy treatments for muscular dystrophy, it is ...
R J, Jankowski, B M, Deasy, J, Huard
openaire   +2 more sources