Results 11 to 20 of about 6,378,630 (248)

The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development [PDF]

Frontiers in Aging Neuroscience, 2015
Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem ...
Julia eMeireles Nogueira, Julia eMeireles Nogueira, Katarzyna eHawrot, Colin eSharpe, Anna eNoble, William M. Wood, Erika C. Jorge, David J. Goldhamer, Gabrielle eKardon, Susanne eDietrich   +9 more
doaj   +2 more sources

Single-Cell Analysis of the Muscle Stem Cell Hierarchy Identifies Heterotypic Communication Signals Involved in Skeletal Muscle Regeneration

Cell Reports, 2020
Summary: Muscle regeneration relies on the regulation of muscle stem cells (MuSCs) through paracrine signaling interactions. We analyzed muscle regeneration in mice using single-cell RNA sequencing (scRNA-seq) and generated over 34,000 single-cell ...
Andrea J. De Micheli, Emily J. Laurilliard, Charles L. Heinke, Hiranmayi Ravichandran, Paula Fraczek, Sharon Soueid-Baumgarten, Iwijn De Vlaminck, Olivier Elemento, Benjamin D. Cosgrove   +8 more
doaj   +3 more sources

Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

Nature Communications, 2018
The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired ...
Srinath C. Sampath, Srihari C. Sampath, Andrew T. V. Ho, Stéphane Y. Corbel, Joshua D. Millstone, John Lamb, John Walker, Bernd Kinzel, Christian Schmedt, Helen M. Blau   +9 more
doaj   +2 more sources

Exercise/Resistance Training and Muscle Stem Cells [PDF]

Endocrinology and Metabolism, 2021
Skeletal muscle has attracted attention as endocrine organ, because exercise-dependent cytokines called myokines/exerkines are released from skeletal muscle and are involved in systemic functions.
So-ichiro Fukada, Ayasa Nakamura
doaj   +1 more source

Vitamin A retinoic acid contributes to muscle stem cell and mitochondrial function loss in old age [PDF]

JCI Insight
Adult stem cells decline in number and function in old age, and identifying factors that can delay or revert age-associated adult stem cell dysfunction are vital for maintaining a healthy lifespan.
Paula M. Fraczek, Pamela Duran, Benjamin A. Yang, Valeria Ferre, Leanne Alawieh, Jesus A. Castor-Macias, Vivian T. Wong, Steve D. Guzman, Celeste Piotto, Klimentini Itsani, Jacqueline A. Larouche, Carlos A. Aguilar   +11 more
doaj   +2 more sources

Protein changes associated with embryonic stem cell differentiation to vascular smooth muscle cells [PDF]

, 2006
PhDEmbryonic stem (ES) cells can differentiate into many different cell lines, including vascular smooth muscle cells (SMCs). The aim of this project is to characterize protein changes during this differentiation process.
Yin, Xiaoke
core   +4 more sources

Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration

Skeletal Muscle, 2022
Skeletal muscle homeostasis and function are ensured by orchestrated cellular interactions among several types of cells. A noticeable aspect of skeletal muscle biology is the drastic cell–cell communication changes that occur in multiple scenarios.
So-ichiro Fukada, Tatsuyoshi Higashimoto, Akihiro Kaneshige   +2 more
doaj   +1 more source

GLI3 regulates muscle stem cell entry into GAlert and self-renewal

Nature Communications, 2022
Primary cilia regulate the processing of the GLI transcription factors and Hedgehog signaling. Here, the authors show that cilia-related GLI3 controls both the quiescence-to-activation transition and self-renewal in muscle stem cells.
Caroline E. Brun, Marie-Claude Sincennes, Alexander Y. T. Lin, Derek Hall, William Jarassier, Peter Feige, Fabien Le Grand, Michael A. Rudnicki   +7 more
doaj   +1 more source

Detection of muscle stem cell-derived myonuclei in murine overloaded muscles

STAR Protocols, 2022
Summary: Muscle satellite cells (MuSCs) supply nuclei to existing myofibers in response to mechanical loading. This myonuclear accretion is critical for efficient muscle hypertrophy.
Akihiro Kaneshige, Takayuki Kaji, Hayato Saito, Tatsuyoshi Higashimoto, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi, So-ichiro Fukada   +8 more
doaj   +1 more source

Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging

Nature Communications, 2022
Repair of muscle damage requires muscle stem cells, which lose regenerative capacity with aging. Here, the authors show that a sensory organelle, the primary cilium, is critical for muscle stem cell proliferation during regeneration and lost with aging.
Adelaida R. Palla, Keren I. Hilgendorf, Ann V. Yang, Jaclyn P. Kerr, Aaron C. Hinken, Janos Demeter, Peggy Kraft, Nancie A. Mooney, Nora Yucel, David M. Burns, Yu Xin Wang, Peter K. Jackson, Helen M. Blau   +12 more
doaj   +1 more source