Results 11 to 20 of about 1,407,681 (347)
GLI3 regulates muscle stem cell entry into GAlert and self-renewal
Nature Communications, 2022 Primary cilia regulate the processing of the GLI transcription factors and Hedgehog signaling. Here, the authors show that cilia-related GLI3 controls both the quiescence-to-activation transition and self-renewal in muscle stem cells.
Caroline E. Brun +7 more
doaj +2 more sources
Satellite Cells and the Muscle Stem Cell Niche
Physiological Reviews, 2013 Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated process involving the activation of various cellular and molecular responses.
Hang, Yin +2 more
openaire +4 more sources
Regulation of muscle stem cell fate
Cell Regeneration, 2022 AbstractSkeletal muscle plays a critical role in human health. Muscle stem cells (MuSCs) serve as the major cell type contributing to muscle regeneration by directly differentiating to mature muscle cells. MuSCs usually remain quiescent with occasionally self-renewal and are activated to enter cell cycle for proliferation followed by differentiation ...
Xin Fu, Cheng-le Zhuang, Ping Hu
openaire +4 more sources
The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development [PDF]
Frontiers in Aging Neuroscience, 2015 Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem ...
Julia eMeireles Nogueira +9 more
doaj +2 more sources
PAX3 confers functional heterogeneity in skeletal muscle stem cell responses to environmental stress
Cell Stem Cell, 2019 SUMMARY Muscle satellite cells (MuSCs) are the quiescent muscle stem cells required for adult skeletal muscle repair. The impact of environmental stress such as pollution on MuSC behavior remains unexplored.
A. Der Vartanian +12 more
semanticscholar +2 more sources
Skeletal Muscle, 2018 Background Klotho is a well-known anti-aging hormone, which serves as a suppressor of aging through a variety of mechanisms. Aging of skeletal muscle is concomitant with a decrease in muscle stem cell function resulting in impaired regeneration.
Hellen E. Ahrens +4 more
doaj +2 more sources
Cell Stem Cell, 2022 Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem cells (satellite cells), a process that becomes less efficient with aging.
X. Hong +15 more
semanticscholar +1 more source
Insight into muscle stem cell regeneration and mechanobiology
Stem cell research & therapeutics, 2023 Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative medicine purposes such as cell therapy.
K. Pang +5 more
semanticscholar +1 more source
Science Translational Medicine, 2023 Duchenne muscular dystrophy (DMD) is a severe and progressive myopathy leading to motor and cardiorespiratory impairment. We analyzed samples from patients with DMD and a preclinical rat model of severe DMD and determined that compromised repair capacity
V. Taglietti +18 more
semanticscholar +1 more source
Cell Stem Cell, 2021 Tissue damage dramatically alters how cells interact with their microenvironment. These changes in turn dictate cellular responses, such as stem cell activation, yet early cellular responses in vivo remain ill defined.
L. Machado +13 more
semanticscholar +1 more source