Results 41 to 50 of about 6,378,630 (248)
Genome Editing-Mediated Utrophin Upregulation in Duchenne Muscular Dystrophy Stem Cells
Molecular Therapy: Nucleic Acids, 2020 Utrophin upregulation is considered a promising therapeutic strategy for Duchenne muscular dystrophy (DMD). A number of microRNAs (miRNAs) post-transcriptionally regulate utrophin expression by binding their cognate sites in the 3′ UTR.
Kasturi Sengupta +5 more
doaj +1 more source
Biomedicines, 2022 Cell therapies for muscle wasting disorders are on the verge of becoming a realistic clinical perspective. Muscle precursor cells derived from human induced pluripotent stem cells (hiPSCs) represent the key to unrestricted cell numbers indispensable for ...
Eric Metzler +5 more
doaj +1 more source
The neural stem cell microenvironment [PDF]
, 2008 In mammals, neural stem cells appear early in development and remain active within the central nervous system for the whole life duration of the organism.
Kazanis, I. +3 more
core +1 more source
Analysis of human satellite cell dynamics on cultured adult skeletal muscle myofibers
Skeletal Muscle, 2021 Background Maintaining stem cells in physiologically relevant states is necessary to understand cell and context-specific signalling paradigms and to understand complex interfaces between cells in situ.
Peter Feige +2 more
doaj +1 more source
Cell Reports, 2015 The molecular mechanisms by which aging affects stem cell number and function are poorly understood. Murine data have implicated cellular senescence in the loss of muscle stem cells with aging.
Anne Bigot +13 more
doaj +1 more source
Generation of iMyoblasts from Human Induced Pluripotent Stem Cells
Bio-Protocol, 2022 Skeletal muscle stem cells differentiated from human-induced pluripotent stem cells (hiPSCs) serve as a uniquely promising model system for investigating human myogenesis and disease pathogenesis, and for the development of gene editing and regenerative ...
Dongsheng Guo +4 more
doaj +1 more source
Skeletal Muscle, 2018 Background Klotho is a well-known anti-aging hormone, which serves as a suppressor of aging through a variety of mechanisms. Aging of skeletal muscle is concomitant with a decrease in muscle stem cell function resulting in impaired regeneration.
Hellen E. Ahrens +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation
Stem Cells International, 2016 An unresolved and critically important question in skeletal muscle biology is how muscle stem cells initiate and regulate the genetic program during muscle development. Epigenetic dynamics are essential for cellular development and organogenesis in early
Rhianna C. Laker, James G. Ryall
doaj +1 more source