Results 61 to 70 of about 1,407,681 (347)
External physical and biochemical stimulation to enhance skeletal muscle bioengineering [PDF]
, 2015 Cell based muscle tissue engineering carries the potential to revert the functional loss of muscle tissue caused by disease and trauma. Although muscle tissue can be bioengineered using various precursor cells, major limitations still remain.; In the ...
Handschin, Christoph +5 more
core +1 more source
Analysis of human satellite cell dynamics on cultured adult skeletal muscle myofibers
Skeletal Muscle, 2021 Background Maintaining stem cells in physiologically relevant states is necessary to understand cell and context-specific signalling paradigms and to understand complex interfaces between cells in situ.
Peter Feige +2 more
doaj +1 more source
Modulation of mTOR signaling as a strategy for the treatment of Pompe disease
EMBO Molecular Medicine, 2017 Mechanistic target of rapamycin (mTOR) coordinates biosynthetic and catabolic processes in response to multiple extracellular and intracellular signals including growth factors and nutrients. This serine/threonine kinase has long been known as a critical
Jeong‐A Lim +5 more
doaj +1 more source
Wnt7a Counteracts Cancer Cachexia
Molecular Therapy: Oncolytics, 2020 Cancer cachexia is a complex metabolic disease so far lacking effective therapy, and it accounts for approximately one third of all cancer-related deaths worldwide.
Manuel Schmidt +2 more
doaj +1 more source
Biomedicines, 2022 Cell therapies for muscle wasting disorders are on the verge of becoming a realistic clinical perspective. Muscle precursor cells derived from human induced pluripotent stem cells (hiPSCs) represent the key to unrestricted cell numbers indispensable for ...
Eric Metzler +5 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Epigenetic regulations control the accessibility of transcription factors to their target regions. Modulation of chromatin accessibility determines which transcripts to be expressed and therefore, defines cell identity.
Anqi Dong +8 more
semanticscholar +1 more source
Cell Reports, 2015 The molecular mechanisms by which aging affects stem cell number and function are poorly understood. Murine data have implicated cellular senescence in the loss of muscle stem cells with aging.
Anne Bigot +13 more
doaj +1 more source
Genome Editing-Mediated Utrophin Upregulation in Duchenne Muscular Dystrophy Stem Cells
Molecular Therapy: Nucleic Acids, 2020 Utrophin upregulation is considered a promising therapeutic strategy for Duchenne muscular dystrophy (DMD). A number of microRNAs (miRNAs) post-transcriptionally regulate utrophin expression by binding their cognate sites in the 3′ UTR.
Kasturi Sengupta +5 more
doaj +1 more source
Generation of iMyoblasts from Human Induced Pluripotent Stem Cells
Bio-Protocol, 2022 Skeletal muscle stem cells differentiated from human-induced pluripotent stem cells (hiPSCs) serve as a uniquely promising model system for investigating human myogenesis and disease pathogenesis, and for the development of gene editing and regenerative ...
Dongsheng Guo +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source