Results 61 to 70 of about 6,378,630 (248)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

CONSTRUCTIVE TISSUE REMODELING BY EXTRACELLULAR MATRIX BIOSCAFFOLDS WITHIN THE AGING SKELETAL MUSCLE MICROENVIRONMENT [PDF]

, 2013
Adult mammalian skeletal muscle tissue retains inherent regenerative capability in response to injury. This regenerative response is contingent upon an activated progenitor cell population and a temporal transition from pro-inflammatory M1 to ...
Sicari, Brian
core  

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

, 2016
The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency, but their exact functions are poorly understood.
Wu, Zhaoting, Onder, Tamer, Tintara, Supisara, Xia, Qing, Asara, John M., Ratanasirintrawoot, Sutheera, Collins, James J., Ng, Shyh-Chang, Trapnell, Cole, Sliz, Piotr, Chandrasekaran, Sriram, Cacchiarelli, Davide, Wang, Longfei, Mikkelsen, Tarjei, Daley, George Q., Marto, Jarrod A., Teitell, Michael A., Ficarro, Scott B., Ross, Christian A., Shinoda, Gen, Zhang, Jin, Li, Hu, Xie, Wen, Yu, Chunxiao, Loh, Yuin-Han, Cahan, Patrick, Seligson, Marc   +26 more
core   +1 more source

We need to talk—how muscle stem cells communicate

Frontiers in Cell and Developmental Biology
Skeletal muscle is one of the tissues with the highest ability to regenerate, a finely controlled process which is critically depending on muscle stem cells.
Karolina Majchrzak, Erik Hentschel, Katja Hönzke, Katja Hönzke, Christiane Geithe, Julia von Maltzahn, Julia von Maltzahn, Julia von Maltzahn   +7 more
doaj   +1 more source

Purification of Immature Neuronal Cells from Neural Stem Cell Progeny [PDF]

Large-scale proliferation and multi-lineage differentiation capabilities make neural stem cells (NSCs) a promising renewable source of cells for therapeutic applications.
Brent A Reynolds, اسفندياري, ابراهيم, Reynolds, Brent A, Maryam Rahman, Osborne, Geoffrey W, Dennis A Steindler, Adams, David J, Dennis A. Steindler, Takahiro Yasuda, Bjorn Scheffler, Brent A. Reynolds, Scheffler, Bjorn, Mohammad G Golmohammadi, گل محمدی, محمد قاسم, Geoffrey W Osborne, Hassan Azari, David J. Adams, Mohammad G. Golmohammadi, Deleyrolle, Loic P, Steindler, Dennis A, Ebrahim Esfandiari, Loic P Deleyrolle, آذری, حسن, Yasuda1, Takahiro, رحمان, مریم, David J Adams, Loic P. Deleyrolle, Geoffrey W. Osborne   +27 more
core   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

eLife, 2017
Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response ...
Wenxuan Liu, Alanna Klose, Sophie Forman, Nicole D Paris, Lan Wei-LaPierre, Mariela Cortés-Lopéz, Aidi Tan, Morgan Flaherty, Pedro Miura, Robert T Dirksen, Joe V Chakkalakal   +10 more
doaj   +1 more source

Muscle Microbiopsy to Delineate Stem Cell Involvement in Young Patients: A Novel Approach for Children With Cerebral Palsy

Frontiers in Physiology, 2020
Cerebral palsy (CP), the single largest cause of childhood physical disability, is characterized firstly by a lesion in the immature brain, and secondly by musculoskeletal problems that progress with age.
Marlies Corvelyn, Nathalie De Beukelaer, Robin Duelen, Jorieke Deschrevel, Anja Van Campenhout, Sandra Prinsen, Ghislaine Gayan-Ramirez, Karen Maes, Guido Weide, Guido Weide, Kaat Desloovere, Maurilio Sampaolesi, Domiziana Costamagna, Domiziana Costamagna   +13 more
doaj   +1 more source