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Stem cell decisions:A twist of fate or a niche market? [PDF]
, 2014 Establishing and maintaining cell fate in the right place at the right time is a key requirement for normal tissue maintenance. Stem cells are at the core of this process.
Näthke, Inke +3 more
core +1 more source
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age
Nature Cell Biology, 2020 Tissue regeneration declines with ageing but little is known about whether this arises from changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two quiescent stem-cell states distinguished by relative CD34 expression ...
Laura Garcia-Prat +21 more
semanticscholar +1 more source
Cell Research, 2020 Necroptosis, a form of programmed cell death, is characterized by the loss of membrane integrity and release of intracellular contents, the execution of which depends on the membrane-disrupting activity of the Mixed Lineage Kinase Domain-Like protein ...
Shen’ao Zhou +17 more
semanticscholar +1 more source
bioRxiv, 2019 Muscle stem cells (MuSCs) are an essential adult stem cell population with the capacity to self-renew and regenerate muscle tissue. Functionally heterogeneous subpopulations of MuSCs have been identified based on their expression of myogenic regulatory ...
A. D. De Micheli +6 more
semanticscholar +1 more source
Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis
bioRxiv, 2020 Growth and maintenance of skeletal muscle fibres depend on coordinated activation and return to quiescence of resident muscle stem-cells (MuSCs). The transcription factor Myogenin (Myog) regulates myocyte fusion during development, but its role in adult ...
M. Ganassi +4 more
semanticscholar +1 more source
Mitochondrial Function in Muscle Stem Cell Fates
Frontiers in Cell and Developmental Biology, 2020 Mitochondria are crucial organelles that control cellular metabolism through an integrated mechanism of energy generation via oxidative phosphorylation.
Debasmita Bhattacharya, A. Scimè
semanticscholar +1 more source
Aging, metabolism and stem cells: Spotlight on muscle stem cells [PDF]
Molecular and Cellular Endocrinology, 2017 All tissues and organs undergo a progressive regenerative decline as they age. This decline has been mainly attributed to loss of stem cell number and/or function, and both stem cell-intrinsic changes and alterations in local niches and/or systemic environment over time are known to contribute to the stem cell aging phenotype.
García-Prat, Laura, Munoz-Canoves, Pura
openaire +3 more sources
Stem Cell Reports, 2020 Summary Muscle stem cells (or muscle satellite cells [MuSCs]) are required for postnatal growth. Yet, the detailed characterization of myogenic progression and establishment of quiescence during this process remains poorly documented. Here, we provide an
F. Gattazzo +4 more
semanticscholar +1 more source
Isolation and Characterization of Neural Crest-Derived Stem Cells From Adult Ovine Palatal Tissue
Frontiers in Cell and Developmental Biology, 2018 Adult mammalian craniofacial tissues contain limited numbers of post-migratory neural crest-derived stem cells. Similar to their embryonic counterparts, these adult multipotent stem cells can undergo multi-lineage differentiation and are capable of ...
Marie-Theres Zeuner +8 more
doaj +1 more source
Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis
Cell Reports, 2020 SUMMARY During aging, there is a progressive loss of volume and function in skeletal muscle that impacts mobility and quality of life. The repair of skeletal muscle is regulated by tissue-resident stem cells called satellite cells (or muscle stem cells ...
A. Shcherbina +14 more
semanticscholar +1 more source