Results 71 to 80 of about 1,407,681 (347)

Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering [PDF]

, 2016
Transplantation of human muscle precursor cells (hMPCs) is envisioned for the treatment of various muscle diseases. However, a feasible noninvasive tool to monitor cell survival, migration, and integration into the host tissue is still missing. METHODS:
Handschin, Christoph, Eberli, Daniel, Ametamey, Simon M, Dinulovic, Ivana, Salemi, Souzan, Meline Stoelting, Deana Haralampieva, Ivana Dinulovic, Tullio Sulser, Haralampieva, Deana, Krämer, Stefanie D., Sulser, Tullio, Stefanie D. Krämer, Christoph Handschin, Daniel Eberli, Thomas Betzel, Simon M. Ametamey, Stoelting, Meline, Betzel, Thomas, Souzan Salemi, Schibli, Roger, Ametamey, Simon M., Roger Schibli, Krämer, Stefanie D; https://orcid.org/   +23 more
core   +1 more source

Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases

Open Biology, 2021
Skeletal muscle possesses a remarkable regenerative capacity that relies on the activity of muscle stem cells, also known as satellite cells. The presence of non-myogenic cells also plays a key role in the coordination of skeletal muscle regeneration ...
Thomas Molina, Paul Fabre, Nicolas A. Dumont   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Angiogenic potential of endothelial progenitor cells and embryonic stem cells [PDF]

, 2011
Background: Endothelial progenitor cells (EPCs) are implicated in a range of pathological conditions, suggesting a natural therapeutic role for EPCs in angiogenesis.
St John, Justin, Kelly, Richard, Kelly, RDW, Stuart Egginton, Rae, Peter, Richard DW Kelly, StJohn, JC, Peter C Rae, St. John, Justin C., Justin C St John, Rae, Peter C., Egginton, Stuart, Rae, PC, Egginton, S, Kelly, Richard D. W., St John, JC   +15 more
core   +1 more source

CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration [PDF]

, 2021
Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is essential for the expansion and ...
Sreenivasan, Krishnamoorthy, Segalés, Jessica, Gomez-del Arco, Pablo, Kim, Johnny, Relaix, F., Redondo, Juan Miguel, Rodríguez de la Rosa, Alejandra, Rodríguez-delaRosa, Alejandra, Muñoz Cánoves, Pura, 1962-, Arco, Pablo Gómez-Del, Relaix, Frederic, Johnny, Kim, Braun, Thomas, Munoz-Canoves, P., Gómez del Arco, Pablo, Mesquita, D., Segalés Dalmau, Jessica, Serrano Sánchez, Antonio L., Serrano, Antonio L, Rodriguez-delaRosa, A., Ianni, A., Serrano, Antonio, Gomez-del Arco, P., Braun, T., Ianni, Alessandro, Muñoz-Cánoves, Pura, Perdiguero, Eusebio, Serrano, A., Kim, J., Espejo, Isabel, Espejo, I., Sreenivasan, K., Miguel Redondo, J., Perdiguero, Eusebio, 1968-, Di Croce, Luciano, Segales, J., Di Croce, L., Perdiguero, E., Mesquita, Diana   +38 more
core   +1 more source

DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation

Stem Cells International, 2016
An unresolved and critically important question in skeletal muscle biology is how muscle stem cells initiate and regulate the genetic program during muscle development. Epigenetic dynamics are essential for cellular development and organogenesis in early
Rhianna C. Laker, James G. Ryall
doaj   +1 more source

Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity. [PDF]

PLoS ONE, 2017
Myogenic stem cells are a promising avenue for the treatment of muscular disorders. Freshly isolated muscle stem cells have a remarkable engraftment ability in vivo, but their cell number is limited.
Hiroshi Sakai, Sumiaki Fukuda, Miki Nakamura, Akiyoshi Uezumi, Yu-Taro Noguchi, Takahiko Sato, Mitsuhiro Morita, Harumoto Yamada, Kunihiro Tsuchida, Shahragim Tajbakhsh, So-Ichiro Fukada   +10 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A conditional mouse model for the characterization of mTORC1 function in muscle and brain [PDF]

, 2010
The Ser/Thr kinase mammalian target of rapamycin (mTOR) regulates cell growth in response to extracellular stimulation with growth factors and to intracellular factors that sense the nutritional and the energy state of the cell.
Cloëtta, Dimitri Yves Reto
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source