Results 31 to 40 of about 6,378,630 (248)

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle

eLife, 2019
In overloaded and regenerating muscle, the generation of new myonuclei depends on muscle satellite cells (MuSCs). Because MuSC behaviors in these two environments have not been considered separately, MuSC behaviors in overloaded muscle remain unexamined.
Sumiaki Fukuda, Akihiro Kaneshige, Takayuki Kaji, Yu-taro Noguchi, Yusei Takemoto, Lidan Zhang, Kazutake Tsujikawa, Hiroki Kokubo, Akiyoshi Uezumi, Kazumitsu Maehara, Akihito Harada, Yasuyuki Ohkawa, So-ichiro Fukada   +12 more
doaj   +1 more source

The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1

Cell Reports, 2016
Summary: Histone variants complement and integrate histone post-translational modifications in regulating transcription. The histone variant macroH2A1 (mH2A1) is almost three times the size of its canonical H2A counterpart, due to the presence of an ∼25 ...
Stefania Dell’Orso, A. Hongjun Wang, Han-Yu Shih, Kayoko Saso, Libera Berghella, Gustavo Gutierrez-Cruz, Andreas G. Ladurner, John J. O’Shea, Vittorio Sartorelli, Hossein Zare   +9 more
doaj   +1 more source

Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]

, 2006
A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G, Austin G Smith, Heavey Barry, Alexandra Benchoua, Benchoua, Alexandra, Smith, Austin,, Benchoua Alexandra, Sally Lowell, Smith Austin G, Lowell, Sally; id_orcid, Smith, Austin, G., Lowell Sally, Lowell, Sally, Heavey, Barry, Barry Heavey   +14 more
core   +1 more source

Progressive and Coordinated Mobilization of the Skeletal Muscle Niche throughout Tissue Repair Revealed by Single-Cell Proteomic Analysis

Cells, 2021
Background: Skeletal muscle is one of the only mammalian tissues capable of rapid and efficient regeneration after trauma or in pathological conditions.
Matthew Borok, Nathalie Didier, Francesca Gattazzo, Teoman Ozturk, Aurelien Corneau, Helene Rouard, Frederic Relaix   +6 more
doaj   +1 more source

Neural crest-derived stem cells [PDF]

, 2010
The neural crest is a transient embryonic structure in vertebrates that gives rise to most of the peripheral nervous system (PNS) and to several non-neural cell types, including smooth muscle cells of the cardiovascular system, pigment cells in the skin,
Sommer, L, Shakhova, O
core   +1 more source

Stem cell decisions:A twist of fate or a niche market? [PDF]

, 2014
Establishing and maintaining cell fate in the right place at the right time is a key requirement for normal tissue maintenance. Stem cells are at the core of this process.
Näthke, Inke, Nathke, Inke; id_orcid, Januschke, Jens, Januschke, Jens; id_orcid   +3 more
core   +1 more source

PGC-1α modulates skeletal muscle regeneration by affecting immune response and satellite cell behavior [PDF]

, 2014
The benefits of exercise on wellbeing have been known to mankind for thousands of years, yet the underlying mechanisms of exercise have been explained only relatively recently.
Dinulović, Ivana
core   +1 more source

Isolation and Characterization of Neural Crest-Derived Stem Cells From Adult Ovine Palatal Tissue

Frontiers in Cell and Developmental Biology, 2018
Adult mammalian craniofacial tissues contain limited numbers of post-migratory neural crest-derived stem cells. Similar to their embryonic counterparts, these adult multipotent stem cells can undergo multi-lineage differentiation and are capable of ...
Marie-Theres Zeuner, Nikolai N. Didenko, David Humphries, Sokratis Stergiadis, Taryn M. Morash, Ketan Patel, Wolf-Dieter Grimm, Wolf-Dieter Grimm, Darius Widera   +8 more
doaj   +1 more source

Wnt7a Counteracts Cancer Cachexia

Molecular Therapy: Oncolytics, 2020
Cancer cachexia is a complex metabolic disease so far lacking effective therapy, and it accounts for approximately one third of all cancer-related deaths worldwide.
Manuel Schmidt, Christine Poser, Julia von Maltzahn   +2 more
doaj   +1 more source

Modulation of mTOR signaling as a strategy for the treatment of Pompe disease

EMBO Molecular Medicine, 2017
Mechanistic target of rapamycin (mTOR) coordinates biosynthetic and catabolic processes in response to multiple extracellular and intracellular signals including growth factors and nutrients. This serine/threonine kinase has long been known as a critical
Jeong‐A Lim, Lishu Li, Orian S Shirihai, Kyle M Trudeau, Rosa Puertollano, Nina Raben   +5 more
doaj   +1 more source