Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL plus multipotent adult progenitor cell clones from peripheral blood [PDF]
, 2004 Background: The CD34- murine stem cell line RM26 cloned from peripheral blood mononuclear cells has been shown to generate hematopoietic progeny in lethally irradiated animals.
Gottgens, Berthold +7 more
core +1 more source
Isolation of Myogenic Stem Cells from Cultures of Cryopreserved Human Skeletal Muscle [PDF]
, 2012 We demonstrate that subpopulations of adult human skeletal muscle-derived stem cells, myogenic endothelial cells (MECs), and perivascular stem cells (PSCs) can be simultaneously purified by fluorescence-activated cell sorting (FACS) from cryopreserved ...
Chen, CW +6 more
core +1 more source
Wnt7a Counteracts Cancer Cachexia
Molecular Therapy: Oncolytics, 2020 Cancer cachexia is a complex metabolic disease so far lacking effective therapy, and it accounts for approximately one third of all cancer-related deaths worldwide.
Manuel Schmidt +2 more
doaj +1 more source
Adult skeletal muscle stem cell migration is mediated by a blebbing/amoeboid mechanism [PDF]
, 2011 Adult skeletal muscle possesses a resident stem cell population called satellite cells which are responsible for tissue repair following damage. Satellite cell migration is crucial in promoting rapid tissue regeneration but is a poorly understood ...
Collins-Hooper, Henry +4 more
core +1 more source
Skeletal muscle stem cell defects in burn-induced cachexia [PDF]
, 2016 ..In an intriguing recent paper published in The Journal of Physiology, Fry and colleagues (Fry et al. 2016) explore the potential involvement of SCs and myonuclei apoptosis in young burn patients, a condition characterized by hyper-metabolism and ...
Farup, Jean +2 more
core +1 more source
Modulation of mTOR signaling as a strategy for the treatment of Pompe disease
EMBO Molecular Medicine, 2017 Mechanistic target of rapamycin (mTOR) coordinates biosynthetic and catabolic processes in response to multiple extracellular and intracellular signals including growth factors and nutrients. This serine/threonine kinase has long been known as a critical
Jeong‐A Lim +5 more
doaj +1 more source
Analysis of human satellite cell dynamics on cultured adult skeletal muscle myofibers
Skeletal Muscle, 2021 Background Maintaining stem cells in physiologically relevant states is necessary to understand cell and context-specific signalling paradigms and to understand complex interfaces between cells in situ.
Peter Feige +2 more
doaj +1 more source
Biomedicines, 2022 Cell therapies for muscle wasting disorders are on the verge of becoming a realistic clinical perspective. Muscle precursor cells derived from human induced pluripotent stem cells (hiPSCs) represent the key to unrestricted cell numbers indispensable for ...
Eric Metzler +5 more
doaj +1 more source
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. [PDF]
, 2014 The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown.
Chen, Robert Y +8 more
core +1 more source
Genome Editing-Mediated Utrophin Upregulation in Duchenne Muscular Dystrophy Stem Cells
Molecular Therapy: Nucleic Acids, 2020 Utrophin upregulation is considered a promising therapeutic strategy for Duchenne muscular dystrophy (DMD). A number of microRNAs (miRNAs) post-transcriptionally regulate utrophin expression by binding their cognate sites in the 3′ UTR.
Kasturi Sengupta +5 more
doaj +1 more source