Results 261 to 270 of about 117,705 (306)
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Orthopaedic Nursing, 2003
The loss of lean body mass (muscle wasting) is initiated by cascades or events that precipitate increased proteolysis. Muscle wasting is stimulated by internal and external factors. Humorally related feedback loops stimulated by disease states, e.g., cancer, inflammatory myopathies, leukemia, or sepsis, and initiated as a response to systemic ...
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The loss of lean body mass (muscle wasting) is initiated by cascades or events that precipitate increased proteolysis. Muscle wasting is stimulated by internal and external factors. Humorally related feedback loops stimulated by disease states, e.g., cancer, inflammatory myopathies, leukemia, or sepsis, and initiated as a response to systemic ...
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Muscle wasting in cardiac cachexia
The International Journal of Biochemistry & Cell Biology, 2005Cardiac cachexia is a serious complication of chronic heart failure which is characterized by complex changes that overall lead to a catabolic/anabolic imbalance resulting in body wasting and a poor prognosis. The wasting process affects all body components, but particularly the skeletal musculature, causing extreme fatigue and weakness, especially in ...
Strassburg, Sabine +2 more
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Scientific American, 2018
The article discusses the use of the gene editing technique CRISPR/Cas9 to increase dystrophin as a way to treat dogs with duchenne muscular dystrophy, referencing a study coauthored by molecular biologist Eric Olson in the "Science" journal.
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The article discusses the use of the gene editing technique CRISPR/Cas9 to increase dystrophin as a way to treat dogs with duchenne muscular dystrophy, referencing a study coauthored by molecular biologist Eric Olson in the "Science" journal.
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Sex Differences in Muscle Wasting
2017With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasome activity, and suppressed protein synthesis and myocyte regeneration.
Lindsey J, Anderson +2 more
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Muscle type and fiber type specificity in muscle wasting
The International Journal of Biochemistry & Cell Biology, 2013Muscle wasting occurs in a variety of conditions, including both genetic diseases, such as muscular dystrophies, and acquired disorders, ranging from muscle disuse to cancer cachexia, from heart failure to aging sarcopenia. In most of these conditions, the loss of muscle tissue is not homogeneous, but involves specific muscle groups, for example ...
CICILIOT, STEFANO +4 more
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Therapeutic approaches for muscle wasting disorders
Pharmacology & Therapeutics, 2007Muscle wasting and weakness are common in many disease states and conditions including aging, cancer cachexia, sepsis, denervation, disuse, inactivity, burns, HIV-acquired immunodeficiency syndrome (AIDS), chronic kidney or heart failure, unloading/microgravity, and muscular dystrophies.
Gordon S, Lynch +2 more
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Muscle wasting in chronic kidney disease
Pediatric Nephrology, 2017Loss of lean body mass is a relevant component of the cachexia, or protein energy wasting (PEW), syndrome. Reduced muscle mass seems to be the most solid criterion for the presence of cachexia/PEW in patients with chronic kidney disease (CKD), and those with greater muscle mass loss have a higher risk of death.
Eduardo A. Oliveira +3 more
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Current Opinion in Clinical Nutrition and Metabolic Care, 2015
The aim of the present review is to examine the impact of mitochondrial dysfunction in cancer cachexia.Oxidative pathways are altered in this tissue during muscle wasting and this seems to be a consequence of mitochondrial abnormalities that include altered morphology and function, decreased ATP synthesis and uncoupling.An alteration of energy balance ...
Josep M, Argilés +2 more
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The aim of the present review is to examine the impact of mitochondrial dysfunction in cancer cachexia.Oxidative pathways are altered in this tissue during muscle wasting and this seems to be a consequence of mitochondrial abnormalities that include altered morphology and function, decreased ATP synthesis and uncoupling.An alteration of energy balance ...
Josep M, Argilés +2 more
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Ubiquitin–protein ligases in muscle wasting
The International Journal of Biochemistry & Cell Biology, 2005Muscle wasting occurs when rates of protein degradation outstrip rates of protein synthesis. Accelerated rates of protein degradation develop in atrophying muscle largely through activation of the ubiquitin-proteasome pathway. The complexity of the ubiquitination process, however, has hampered our understanding of how this pathway is activated in ...
Pei Rang, Cao +2 more
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Cytokine Signaling in Skeletal Muscle Wasting
Trends in Endocrinology & Metabolism, 2016Skeletal muscle wasting occurs in a variety of diseases including diabetes, cancer, Crohn's disease, chronic obstructive pulmonary disease (COPD), disuse, and denervation. Tumor necrosis factor α (TNF-α) is involved in mediating the wasting effect. To date, a causal relationship between TNF-α signaling and muscle wasting has been established in animal ...
Jin, Zhou +4 more
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