Results 11 to 20 of about 389,322 (305)

Excess TGF-β mediates muscle weakness associated with bone metastases in mice [PDF]

Nature Medicine, 2015
Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no effective treatment. Here we find that seven different mouse models of human osteolytic bone metastases-representing breast, lung and prostate cancers, as well as ...
Andersson, Daniel C., Benassi, Maria Serena, Cao, Xu, Charkhzarrin, Sahba, Chiechi, Antonella, Guise, Theresa A., Haynes, Ashley, John, Sutha, Khatiwada, Pooja, Marks, Andrew R., Mohammad, Khalid S., Niewolna, Maria, Reiken, Steven, Roodman, G. David, Trivedi, Trupti, Umanskaya, Alisa, Wang, Xiao, Waning, David L., Witzmann, Frank A., Wright, Laura E., Wronska, Anetta, Xie, Wenjun, Zhen, Gehua   +22 more
core   +4 more sources

Antineutrophil cytoplasmic antibody-associated vasculitis with predominant truncal muscle weakness: a retrospective case series

Frontiers in Neurology, 2023
IntroductionAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) frequently leads to mononeuritis multiplex, which are characterized by distal weakness associated with sensory disturbances.
Joe Nemoto, Hideaki Nishihara, Hideaki Nishihara, Taro Yasuhi, Ryota Sato, Michiaki Koga, Takashi Kanda, Masayuki Nakamori   +7 more
doaj   +1 more source

An itchy rash and muscle weakness

Clinical Case Reports, 2021
Dermatomyositis is a rare disease affecting primarily skin and muscles and is associated with malignancies, especially in at‐risk patients. Clinical presentations vary widely but proximal muscle weakness and typical skin findings should prompt ...
Brian L. Risavi, Justin Puller, Kristin Juhasz   +2 more
doaj   +1 more source

Pathogenesis of muscle weakness in inflammatory myositis

Indian Journal of Rheumatology, 2020
Idiopathic inflammatory myositis (IIM) is a heterogeneous group of autoimmune diseases. These are characterized by muscle weakness and fatigue along with other systemic manifestations, ranging from pulmonary alveolitis to vasculopathic ulcers.
Sai Kumar Dunga, T G Sundaram, Chengappa G Kavadichanda   +2 more
doaj   +1 more source

Distal muscle weakness is a common and early feature in long-term enzyme-treated classic infantile Pompe patients

Orphanet Journal of Rare Diseases, 2020
Background Enzyme replacement therapy (ERT; alglucosidase alfa) has improved the prospects for patients with classic infantile Pompe disease considerably.
J. J. A. van den Dorpel, E. Poelman, L. Harlaar, H. A. van Kooten, L. J. van der Giessen, P. A. van Doorn, A. T. van der Ploeg, J. M. P. van den Hout, N. A. M. E. van der Beek   +8 more
doaj   +1 more source

Muscle Weakness [PDF]

Diabetes, 2006
The aim of the study was to determine the progression of muscle weakness in long-term diabetes and its relation to the neuropathic condition. Thirty patients were recruited from a cohort of 92 diabetic patients who participated in a study on muscular function 6–8 years earlier.
Christer S. Andreassen, Johannes Jakobsen, Henning Andersen   +2 more
openaire   +1 more source

MicroRNA regulatory networks associated with abnormal muscle repair in survivors of critical illness

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Intensive care unit (ICU)‐acquired weakness is characterized by muscle atrophy and impaired contractility that may persist after ICU discharge.
Christopher J. Walsh, Carlos Escudero King, Muskan Gupta, Pamela J. Plant, Margaret J. Herridge, Sunita Mathur, Pingzhao Hu, Judy Correa, Sameen Ahmed, Anne Bigot, Claudia C. dosSantos, Jane Batt, Submitted on behalf of the MusclE and Nerve Dysfunction (MEND)‐ICU Group and Canadian Critical Care Translational Biology Group (CCCTBG)   +12 more
doaj   +1 more source

Case Report: Lower Limb Muscle Weakness in a Child With Kawasaki Disease

Frontiers in Pediatrics, 2022
Kawasaki disease (KD) is a systemic vasculitis that may impact multiple organ systems in children. Myositis is an unusual presentation of KD that presents with muscle weakness.
Lilin Huang, Shumei Peng, Jing Li, Danyu Xie   +3 more
doaj   +1 more source

Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness [PDF]

, 2019
Breast cancer bone metastases often cause a debilitating non-curable condition with osteolytic lesions, muscle weakness and a high mortality. Current treatment comprises chemotherapy, irradiation, surgery and anti-resorptive drugs that restrict but do ...
Brandt, Diana, Hesse, Eric, Pamperin, Jenny, Saito, Hiroaki, Schröder, Saskia, Taipaleenmäki, Hanna   +5 more
core   +1 more source

Nationwide handgrip strength values and factors associated with muscle weakness in older adults: findings from the Brazilian Longitudinal Study of Aging (ELSI-Brazil)

BMC Geriatrics, 2022
Background Handgrip strength (HGS) is a simple, quick, inexpensive, and highly reliable method for the assessment of muscle strength in clinical practice and epidemiological studies.
Bruno de Souza Moreira, Amanda Cristina de Souza Andrade, Juliana Lustosa Torres, Luciana de Souza Braga, Alessandra de Carvalho Bastone, Juliana Vaz de Melo Mambrini, Maria Fernanda Lima-Costa   +6 more
doaj   +1 more source