Results 61 to 70 of about 3,255,580 (393)

The systemic bone protective effects of Gushukang granules in ovariectomized mice by inhibiting osteoclastogenesis and stimulating osteoblastogenesis

open access: yesJournal of Pharmacological Sciences, 2018
Primary osteoporosis (POP), which is caused by unbalanced bone remodeling, leads to significant economic and societal burdens globally. Gushukang (GSK) granule serves as one commonly used prescription for POP in Traditional Chinese Medicine (TCM).
Qiang Wang   +11 more
doaj  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Barefoot and shod running: their effects on foot muscle kinetics [PDF]

open access: yes, 2015
Running shoe technology has advanced significantly in the last 50 years, although the overall injury rate has yet to decrease. Barefoot (BF) running has become increasing more popular in the last 10 years.
Sinclair, Jonathan Kenneth
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Effects of Caffeine Supplementation on the Recovery of Professional Soccer Players

open access: yesMuscles, 2022
(1) Introduction: Soccer players face high demand for training and games. To facilitate their performance, many studies have investigated ergogenic supplements that can assist in the recovery and performance of players.
Thais Marques e Silva   +3 more
doaj   +1 more source

The correlation between wing kinematics and steering muscle activity in the blowfly Calliphora vicina [PDF]

open access: yes, 2001
Determining how the motor patterns of the nervous system are converted into the mechanical and behavioral output of the body is a central goal in the study of locomotion.
Balint, Claire N., Dickinson, Michael H.
core  

Muscle Development: Making Drosophila muscle [PDF]

open access: yesCurrent Biology, 1995
Analysis of flies with mutations in the gene encoding the D-mef2 transcription factor identifies it as a controller of differentiation in multiple muscle cell types; it is the first such gene to be described.
openaire   +3 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Loop Diuretics and Sarcopenia: A Potential Association

open access: yesMuscles, 2023
Background: Loop diuretics (LDs) are used to treat various health conditions including heart failure (HF), liver cirrhosis, and chronic kidney disease (CKD).
Nikolaos D. Karakousis   +1 more
doaj   +1 more source

Restoration of grasp following paralysis through brain-controlled stimulation of muscles

open access: yesNature, 2012
Patients with spinal cord injury lack the connections between brain and spinal cord circuits that are essential for voluntary movement. Clinical systems that achieve muscle contraction through functional electrical stimulation (FES) have proven to be ...
C. Ethier   +3 more
semanticscholar   +1 more source

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