Results 71 to 80 of about 3,255,580 (393)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Early Rehabilitation with Weight-bearing Standing-shaking-board Exercise in Combination with Electrical Muscle Stimulation after Anterior Cruciate Ligament Reconstruction [PDF]

, 2012
The objective of early rehabilitation after anterior cruciate ligament (ACL) reconstruction is to increase the muscle strength of the lower extremities. Closed kinetic chain (CKC) exercise induces co-contraction of the agonist and antagonist muscles. The
Fujii, Toshihiro, Hayashi, Masamichi, Kawamura, Kenji, Ozaki, Toshifumi, Takahashi, Kingo   +4 more
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

The gastropod-symbiotic sea anemone genus Isosicyonis Carlgren, 1927 (Actiniaria : Actiniidae): a new species from the Weddell Sea (Antarctica) that clarifies the taxonomic position of the genus [PDF]

, 2008
A second species of the sea anemone genus Isosicyonis is described and illustrated from 16 specimens collected in the Weddell Sea (Antarctica) on the Polarstern cruises ANT XVII/3, ANT XXI/2 and ANT XXIII/8. Isosicyonis striata n. sp.
López González, Pablo José, Rodríguez, Estefanía   +1 more
core   +3 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Aging and Muscle Fatigability in the Upper Extremity [PDF]

, 2017
Aging is accompanied by reductions in strength and contraction velocity, and increased fatigability of limb muscles during high-velocity dynamic contractions.
Kuplic, Andrew
core   +1 more source

Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues [PDF]

, 2018
Skeletal muscle comprises a family of diverse tissues with highly specialized functions. Many acquired diseases, including HIV and COPD, affect specific muscles while sparing others.
Andrade, Francisco, Douglas, Collin M, Esser, Karyn A, Gong, Ming C, Gutierrez-Monreal, Miguel A, Hoffmann, Christy, Hughes, Laura D, Hughes, Michael E, Lahens, Nicholas F, Lewis, Scott A, Li, Jiajia, Riley, Lance A, Terry, Erin E, Wallace, Matthew J, Zhang, Xiping   +14 more
core   +4 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Sarcopenia and Pleural Effusions: Exploring a Potential Link

Muscles
Recent studies indicate a significant relationship between malnutrition, frailty, and pleural effusion (PE), highlighting the critical role of muscle mass in patient outcomes. This review investigates the association between sarcopenia—characterized by a
Georgios I. Barkas, Nikolaos D. Karakousis, Zoe Daniil, Konstantinos I. Gourgoulianis, Ourania S. Kotsiou   +4 more
doaj   +1 more source

Does a SLAP lesion affect shoulder muscle recruitment as measured by EMG activity during a rugby tackle? [PDF]

, 2010
Background: The study objective was to assess the influence of a SLAP lesion on onset of EMG activity in shoulder muscles during a front on rugby football tackle within professional rugby players.
A Bathgate, A Burkhart, A Cresswell, AL Miller, BD Wilson, CD Morgan, Christer Rolf, CM Powers, Conley, DA Watters, DC Hughes, DF Gerrard, DJ Wadsworth, FH Fu, G David, G Fleisig, G Jull, GM Gartsman, H Seward, HC Hsu, Ian G Horsley, ID Gowan, J Ide, J Jerosch, J Oveson, J Towsend, JB Myers, JD Grauer, JHM Brooks, JR Andrews, JT Bencardino, KL Quarrie, L Herrington, Lee C Herrington, LG Portney, M Allegrucci, M Garraway, M Solomonow, MI Scovazzo, MJ Pagnani, MJ Pagnani, MW Maffett, MW Rodosky, N Gibb, N Poulliart, N Sharkey, P Hodges, P Hodges, PB O'Sullivan, PJ Bedford, PJ McMahon, PJ McNair, R Glouseman, R Glousman, R Lysens, RA Ekstrom, RG DeMont, RW Norman, S Conte, S Taimela, SA Hess, SB Swanik, SJ Snyder, SK Saha, TH Mercer, V Dietz, VT Inman, W Van Mechelen, WB Kibler, WH Meeuwisse, WH Meeuwisse   +70 more
core   +4 more sources