Results 241 to 250 of about 134,576 (312)

Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by altered metabolome and energy homeostasis, manifesting with body mass index changes and hypermetabolism—both prognostic of disease progression and survival.
Kai Guo, Masha G. Savelieff, Dae‐Gyu Jang, Samuel J. Teener, Lili Zhao, Junguk Hur, Stephen A. Goutman, Eva L. Feldman   +7 more
wiley   +1 more source

Post-Marketing Safety of Spinal Muscular Atrophy Therapies: Analysis of Spontaneous Adverse Drug Reactions from EudraVigilance. [PDF]

J Clin Med
Belančić A, Mas P, Miletić L, Kovačić Bytyqi B, Vitezić D.   +4 more
europepmc   +1 more source

Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The objective of this study was to investigate the differences in cyclic alternating patterns (CAP) metrics, a non‐rapid eye movement (NREM) sleep physiological rhythm, among recently diagnosed patients with Parkinson's disease (PD), and individuals at high and low risk for developing PD based on genetic and prodromal risk.
Andrew Dagay, Shlomit Katzav, Danielle Wasserman, Valentina Gnoni, Anat Mirelman, Riva Tauman   +5 more
wiley   +1 more source

Correction: "…They were just treating her Symptom by Symptom": maternal experiences of having a child with spinal muscular atrophy in Ghana. [PDF]

BMC Palliat Care
Tawiah ED, Sarfo JO.
europepmc   +1 more source

Phosphatemia is an Independent Prognostic Factor in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective The objective of this study was to evaluate the prognostic value of several muscle damage biomarkers. Methods Data from Piemonte and Valle d'Aosta Amyotrophic Lateral Sclerosis (PARALS) were considered for this study. Survival was defined as the time from diagnosis to death, tracheostomy, or the censoring date.
Rosario Vasta, Emanuele Koumantakis, Antonio Canosa, Umberto Manera, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Enrico Matteoni, Francesca Di Pede, Filippo De Mattei, Filippo Vergnano, Jessica Mandrioli, Cecilia Simonini, Ilaria Martinelli, Fabiola De Marchi, Letizia Mazzini, Cristina Moglia, Andrea Calvo, Adriano Chiò   +18 more
wiley   +1 more source

Gene therapy for spinal muscular atrophy: timing is key. [PDF]

Lancet Reg Health Eur
Servais L.
europepmc   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

Onasemnogene-abeparvovec administration to premature infants with spinal muscular atrophy. [PDF]

Ann Clin Transl Neurol
Brown SM, Ajjarapu AS, Ramachandra D, Blasco-Pérez L, Costa-Roger M, Tizzano EF, Sumner CJ, Mathews KD.   +7 more
europepmc   +1 more source

Towards Polymer Composite‐Based Transient Electronic Systems

Advanced NanoBiomed Research, EarlyView.
Biodegradable electronic systems are gaining attention for implantable biomedical applications, targeting disease treatment and lifespan extension. This review covers advances in biocompatible, biodegradable polymer composites using synthetic and natural polymers with conductive, semiconductive, and insulating fillers.
Gwan‐Jin Ko, Venkata Ramesh Naganaboina, Emad S. Goda, Ankan Dutta, Huanyu Cheng, Suk‐Won Hwang   +5 more
wiley   +1 more source