Results 11 to 20 of about 9,766,746 (345)
Oxidative Stress in DNA Repeat Expansion Disorders: A Focus on NRF2 Signaling Involvement
Biomolecules, 2020 DNA repeat expansion disorders are a group of neuromuscular and neurodegenerative diseases that arise from the inheritance of long tracts of nucleotide repetitions, located in the regulatory region, introns, or inside the coding sequence of a gene ...
Piergiorgio La Rosa +3 more
doaj +1 more source
The ferroptosis inducer RSL3 triggers interictal epileptiform activity in mice cortical neurons
Frontiers in Cellular Neuroscience, 2023 Epilepsy is a neurological disorder characterized by recurrent seizures, which result from excessive, synchronous discharges of neurons in different brain areas. In about 30% of cases, epileptic discharges, which vary in their etiology and symptomatology,
Michela Giustizieri +8 more
doaj +1 more source
Integrated Multi-Omics Analysis for Inferring Molecular Players in Inclusion Body Myositis
Antioxidants, 2023 Inclusion body myositis (IBM) is an acquired inflammatory myopathy affecting proximal and distal muscles that leads to weakness in patients over 50.
Judith Cantó-Santos +15 more
doaj +1 more source
Italian Journal of Pediatrics, 2020 Background Childhood epilepsies are a heterogeneous group of conditions differing in diagnostic criteria, management, and outcome. Late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) is a neurodegenerative condition caused by biallelic TPP1 ...
Elisabetta Amadori +17 more
doaj +1 more source
Ferroptosis in Friedreich’s Ataxia: A Metal-Induced Neurodegenerative Disease
Biomolecules, 2020 Ferroptosis is an iron-dependent form of regulated cell death, arising from the accumulation of lipid-based reactive oxygen species when glutathione-dependent repair systems are compromised.
Piergiorgio La Rosa +4 more
doaj +1 more source
Epilepsia Open, 2023 Objective NPRL3‐related epilepsy (NRE) is an emerging condition set within the wide GATOR‐1 spectrum with a particularly heterogeneous and elusive phenotypic expression.
Alice Dainelli +11 more
doaj +1 more source
Exertional heat stroke-related rhabdomyolysis recurring twice in a 12-year-old boy athlete [PDF]
Pediatric Emergency Medicine Journal, 2022 Exertional heat stroke (EHS) is a life-threatening entity characterized by elevated core temperature with potential for multiorgan dysfunction. EHS-related rhabdomyolysis usually occurs in the early phase.
Soo Jin Kwon +5 more
doaj +1 more source
Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies
Frontiers in Endocrinology, 2022 Diabetes mellitus (DM) is a typical chronic disease that can be divided into 2 types, dependent on insulin deficiency or insulin resistance. Incidences of diabetic complications gradually increase as the disease progresses.
Yuntian Shen +11 more
semanticscholar +1 more source
Global epidemiology of Duchenne muscular dystrophy: an updated systematic review and meta-analysis
Orphanet Journal of Rare Diseases, 2020 Background Duchenne Muscular Dystrophy (DMD) is a rare disorder caused by mutations in the dystrophin gene. A recent systematic review and meta-analysis of global DMD epidemiology is not available.
S. Crisafulli +5 more
semanticscholar +1 more source
Magnesium in Aging, Health and Diseases
Nutrients, 2021 Several changes of magnesium (Mg) metabolism have been reported with aging, including diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting. Mild Mg deficits are generally asymptomatic and clinical signs are usually non-specific or
M. Barbagallo, N. Veronese, L. Dominguez
semanticscholar +1 more source