Results 61 to 70 of about 775 (126)

Mitochondrial permeability transition in skeletal muscle phenocopies muscle alterations seen in cancer cachexia and other wasting conditions

The Journal of Physiology, EarlyView.
Abstract figure legend Skeletal muscle wasting conditions are characterized by muscle fibre atrophy, mitochondrial respiratory dysfunction, mitochondrial depletion and fragmentation of acetylcholine receptor (AChR) cluster at the neuromuscular junction.
Maya Semel, Cole Lukasiewicz, Sarah Skinner, Mark R. Viggars, Sung Gi Noh, Martin Picard, Abbey‐Gale Mannings, Michael S. Cohen, Dennis W. Wolan, Terence E. Ryan, Russell T. Hepple   +10 more
wiley   +1 more source

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

Arthritis Care &Research, Volume 78, Issue 10, Page 1424-1437, October 2026.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

High Health Care Utilization Preceding Diagnosis With Juvenile Idiopathic Arthritis

Arthritis Care &Research, Volume 78, Issue 10, Page 1544-1551, October 2026.
Objective Although early diagnosis improves long‐term outcomes, patients with juvenile idiopathic arthritis (JIA) often experience prolonged, circuitous paths to diagnosis. To inform diagnostic improvement, we sought to characterize health care utilization in the year preceding diagnosis. Methods We identified 10,021 patients with an incident diagnosis
Anna Costello, Rui Xiao, Xuemei Zhang, Jahan Jazayeri, Irit R. Rasooly, Pamela F. Weiss   +5 more
wiley   +1 more source

Development of Musculoskeletal Problems Caused by Poor Ergonomics in Dentists. Systematic Review

Medisur
Musculoskeletal pathologies are the most common and costly occupational injuries associated with the musculoskeletal system, which generate physical and functional alterations in the joints and other tissues.
Adriana María García Novillo, Gilson Steven Sánchez Maldonado   +1 more
doaj  

Per‐ and Polyfluoroalkyl Substances and Knee Osteoarthritis: Data From the Osteoarthritis Initiative

Arthritis &Rheumatology, Volume 78, Issue 10, Page 2082-2088, October 2026.
Objective To examine whether concentrations of specific per‐ and polyfluoroalkyl substances (PFAS) and a mixture of PFAS relate to incident knee osteoarthritis (KOA) and knee pain progression. Methods Among a case‐cohort sample from the OA Initiative (n = 1,878), we examined associations of serum concentrations of eight PFAS with odds of developing ...
Jeffrey B. Driban, Lisa B. Rokoff, Bing Lu, Timothy E. McAlindon, Charles B. Eaton, Mary B. Roberts, Diana Mathes, Colleen Lestician, Zhijin Carrie Xu, Zhihua Tina Fan, Shawn P. O'Leary, Ida K. Haugen, Jérémie Sellam, Alice Courties, Abby F. Fleisch   +14 more
wiley   +1 more source

ESTUDO COMPARATIVO ENTRE EXERCICIOS REALIZADOS NO SOLO E NA ÁGUA AQUECIDA DURANTE A FASE GESTACIONAL: ESTUDO DE CASO

Revista UniVap, 2012
O período gestacional é marcado por alterações musculoesqueléticas que podem resultar em dor e limitações funcionais. Este estudo teve como objetivo avaliar os efeitos terapêuticos de exercícios realizados sob imersão em água aquecida e no solo sobre o ...
Djenifer Queiroz Souza, Izabela Santos Mendes, Karina da Silva Marson, Ana Carolina Lacerda Borges, Mariana César Ribeiro Reis, Susane Moreira Machado, Paulo Roberto Garcia Lucareli, Mario Oliveira Lima, Fernanda Pupio Silva Lima   +8 more
doaj   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

Arthritis &Rheumatology, Volume 78, Issue 10, Page 2074-2081, October 2026.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo, Norio Hanata, Eduardo Patino‐Martinez, Ronald Holewinski, Ana Barrera‐Vargas, Javier Merayo‐Chalico, Scott A. Coonrod, David A. Fox, Mariana J. Kaplan, Carmelo Carmona‐Rivera   +9 more
wiley   +1 more source

Hydroxyapatite‐Coated Ti6Al4V With Liposome‐Encapsulated Gooseberry Extract for Orthopedic Applications

Journal of Biomedical Materials Research Part A, Volume 114, Issue 10, October 2026.
Schematic illustration of gooseberry extract encapsulation in liposomes, loading onto hydroxyapatite‐coated Ti6Al4V, and subsequent evaluation of drug release, osteoblast response, osteosarcoma cell response, antibacterial activity, and bone healing. ABSTRACT This study investigates gooseberry (Phyllanthus emblica) extract (GB) as a bioactive additive ...
Bryson White, Susmita Bose
wiley   +1 more source

Metastatic Bone Disease Is Associated With Longitudinal Muscle Loss and Reduced Survival in Kidney Cancer

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Cachexia is a multifactorial muscle wasting syndrome and is responsible for 20%–40% of cancer‐related deaths, yet no FDA‐approved therapies exist. Preclinical studies suggest that metastatic bone disease may contribute to muscle wasting, but this relationship has not been evaluated in clinical populations.
Jon‐Luc Poirier, Samuel T. Jines, Libbie M. Silverman, Anuradha Valiya Kambrath, L. Daniel Wurtz, Teresa A. Zimmers, Christopher D. Collier   +6 more
wiley   +1 more source

Not All Cams Are Equal: MRI‐Based Statistical Shape Modeling Reveals High Variability in Cam Shape in a Large FAI Cohort

Journal of Orthopaedic Research, Volume 44, Issue 10, October 2026.
ABSTRACT Evidence indicates that alpha angle (AA) is inadequate for describing cam morphology, contributing to poor patient selection and clinical outcomes for cam‐type femoroacetabular impingement syndrome (FAI). While techniques such as statistical shape modeling (SSM) have advanced knowledge of 3D femoral morphology, many studies utilize computed ...
Catherine Yuh, Philip Malloy, Sage Zonner, Cameron Gerhold, Eric Hu, Jesus Cervantes, Jorge Chahla, Shane J. Nho, Steven P. Mell   +8 more
wiley   +1 more source