Results 71 to 80 of about 775 (126)

Ciliary Ift20 and Wwtr1 Coordinate Transforming Growth Factor‐β Receptor II Signaling to Maintain Bone–Fat Balance in Skeletal Homeostasis

MedComm, Volume 7, Issue 10, October 2026.
Deletion of Ift20 and Wwtr1 in osteoprecursors promoted adipogenic differentiation while suppressing osteogenesis and bone remodeling through dysregulation of TGF‐β signaling. Mechanistically, Ift20 stabilized TβRII by inhibiting c‐Cbl‐mediated ubiquitination and proteasomal degradation. In parallel, Wwtr1 functioned as a transcriptional regulator that
Yang Li, Yang Yang, Shuting Yang, Huijuan Chang, Yi‐Ping Li, Shuying Yang   +5 more
wiley   +1 more source

Sensorineural Hearing Impairment and Subclinical Atherosclerosis in Rheumatoid Arthritis Patients Without Traditional Cardiovascular Risk Factors

The Turkish Journal of Gastroenterology, 2016
Objectives: This study aims to evaluate the association of hearing impairment with carotid intima-media thickness and subclinical atherosclerosis in rheumatoid arthritis (RA) patients.
Hector MACIAS-REYES, Jorge I. GAMEZ-NAVA, Laura GONZALEZ-LOPEZ, Carlos O. YANOWSKY-GONZALEZ, Rosa E. NAVARRO-HERNANDEZ, Eduardo GOMEZ-BAÑUELOS, Cesar G. CHAVEZ-MARTIN, Cynthia R. CARDENAS-CONTRERAS, Sergio DURAN-BARRAGAN, Monica VAZQUEZ-DEL MERCADO   +9 more
doaj  

β‐Catenin‐Deficient Intervertebral Disc Cells Reduce Chemotactic Transcription and Myeloid Cell Recruitment to Injured Discs of Mice

Aging Cell, Volume 25, Issue 10, October 2026.
(Left) In young discs, Wnt signaling‐replete nucleus pulposus cells secrete ECM components and, upon disc injury, cytokines to recruit myeloid cells. (Right) Whereas, β‐catenin‐deficient disc cells, modeling age‐related absence of Wnt signaling, exhibit reduced anabolic activity and, upon disc injury, secrete fewer pro‐inflammatory cytokines and ...
Tori M. Kroon, Jazz Munitz, Anna Ranzenigo, Martin Umali, William Wang, Jonathan J. Huang, Abraham J. P. Teunissen, Nilsson Holguin   +7 more
wiley   +1 more source

ZNF865 (BLST) a Novel Regulator of DNA Damage and Cell Senescence in Back Pain

Aging Cell, Volume 25, Issue 10, October 2026.
ZNF865 (BLST) has previously been classified as part of the “unknome”, but here in the context of back pain, we demonstrate the first functional characterization of ZNF865. We demonstrate that it regulates genomic stability and subsequent senescence, and that downregulation in the intervertebral disc leads to pain behavior in rodent models.
Christian Lewis, Hunter Levis, Jonah Holbrook, Jacob T. Polaski, Timothy D. Jacobsen, Josh Mizels, Molly Czachor, Sarah E. Gullbrand, Brian Diekman, James C. Iatridis, Jason Gertz, Brandon Lawrence, Robby D. Bowles   +12 more
wiley   +1 more source

Microbial‐derived Exerkines preserve muscle size and function during disuse in aged mice in a sex‐dependent manner

Physiological Reports, Volume 14, Issue 19, October 2026.
Abstract Disuse‐induced muscle atrophy is a critical clinical challenge in older adults. Existing countermeasures have largely failed to preserve muscle size and function, underscoring the need for novel therapeutic strategies. We recently identified pipecolic acid and succinate (PAS) as microbial‐derived exerkines that prevent disuse‐induced atrophy ...
Jainil Daredia, Taylor R. Valentino, Ahmed Ismaeel, Yuan Wen, John J. McCarthy, Benjamin I. Burke   +5 more
wiley   +1 more source

[Healthy lifestyle habits, musculoskeletal system and its impact on the working population in the post-pandemic]. [PDF]

Rev Salud Publica (Bogota), 2023
Hernández-Duarte WA.
europepmc   +1 more source

Morbidades musculoesqueléticas referidas em jogadores de futebol não profissionais

Revista Brasileira de Futsal e Futebol, 2018
Introdução: O futebol apresenta elevada incidência de lesão por tratar-se de um esporte caracterizado por intenso contato físico, realização de movimentos complexos e por exigir alta capacidade aeróbica em treinos e jogos de seus praticantes.
Ronaldo Dias Magalhães Junior, Marco Antônio Basso Filho, Romes Bittencourt Nogueira de Sousa, Gustavo Rodrigues Pedrino, Adroaldo José da Casa Junior, Ana Cristina Silva Rebelo   +5 more
doaj  

Orthopedics and Traumatology Skill Matrix for Musculoskeletal System Approach by Medical Graduates. [PDF]

Rev Bras Ortop (Sao Paulo), 2023
Siqueira EM, Pereira AA, Oliveira IAKM.
europepmc   +1 more source

Development of a convolutional neural network for diagnosing osteoarthritis, trained with knee radiographs from the ELSA-Brasil Musculoskeletal. [PDF]

Radiol Bras, 2023
Domingues JG, Araujo DC, Costa-Silva L, Machado AMC, Machado LAC, Veloso AA, Barreto SM, Telles RW.   +7 more
europepmc   +1 more source

Differences in chronic musculoskeletal pain among male and female Brazilian university professors. [PDF]

Rev Esc Enferm USP
Pinto MJS, Failde I, Hortense P.
europepmc   +1 more source