Results 71 to 80 of about 715 (130)
ABSTRACT Glycosaminoglycans (GAGs) like chondroitin sulfate (CS) influence both mechanical properties and biological signals within the tissue microenvironment. CS modifications have been prevalent in a range of biomaterial design strategies, particularly those with a focus on wound healing.
Kyle B. Timmer +2 more
wiley +1 more source
ABSTRACT Introduction Progressive collapsing foot deformity (PCFD) is a complex condition characterized by multiple combined deformities, with a higher reported prevalence in women. Most studies of PCFD morphology have focused on single joints and evaluated both sexes together, leaving the interrelationship of multiple joints in females specifically ...
Takuma Miyamoto +6 more
wiley +1 more source
[Healthy lifestyle habits, musculoskeletal system and its impact on the working population in the post-pandemic]. [PDF]
Hernández-Duarte WA.
europepmc +1 more source
This study investigated the effect of spinal bone metastasis (BM) on the biomechanical environment of the spine through estimates of load, strength, and the load‐to‐strength ratio (LSR). Our study suggests that task‐specific differences related to cancer, lesion type, and vertebral location differentially affect the biomechanical environment of the ...
Dennis E. Anderson +13 more
wiley +1 more source
In a large cohort of adults with chronic low back pain, real‐time ecological momentary assessment and multisite wearable sensors were used to characterize daily pain and physical activity in participants' natural environments. While participants frequently reported low pain intensity and moderate activity levels, objective sensor data from the wrist ...
Kevin M. Bell +19 more
wiley +1 more source
Quantitative MRI reveals age‐related degeneration of lumbar intervertebral discs. Axial T2 and T2* relaxation time maps from representative young (15‐month) and old (130‐month) sheep demonstrate substantially higher relaxation times in young discs, particularly within the nucleus pulposus, indicating a well‐hydrated and proteoglycan‐rich matrix.
Yaqoub Yusuf +10 more
wiley +1 more source
Impact of E‐Beam Sterilization on Bioglass Composite Shape Memory Scaffolds
Electron beam (E‐beam) sterilization is an attractive alternative to conventional methods (e.g., ethylene oxide) to sterilize medical devices such as scaffolds used to heal bone defects. Herein, the impact of E‐beam sterilization on the properties of “self‐fitting” shape memory polymer (SMP) scaffolds prepared from resorbable polyesters and a bioglass ...
Brandon M. Nitschke +2 more
wiley +1 more source
A Novel Model System to Identify Cellular and Molecular Defects Underlying Rare Genetic Disorders
ABSTRACT Ankyloblepharon‐ectodermal defects‐cleft lip/palate (AEC) is a disorder caused by autosomal‐dominant mutations in the TP63 gene. AEC is characterised by the presence of severe and painful skin erosions that can take years to heal. Current treatment options for these devastating lesions are limited, highlighting the need for new therapeutic ...
Maddison N. Salois +4 more
wiley +1 more source
Therapeutic advances in pruritus as a model of personalized medicine
Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung +2 more
wiley +1 more source
Orthopedics and Traumatology Skill Matrix for Musculoskeletal System Approach by Medical Graduates. [PDF]
Siqueira EM, Pereira AA, Oliveira IAKM.
europepmc +1 more source

