Results 161 to 170 of about 504,957 (283)

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Lymphatic-immune interactions in the musculoskeletal system. [PDF]

Front Immunol
Liu H, Liu L, Zhang Y, Tian Q, Ding Z, Chen J, Kusumbe AP.   +6 more
europepmc   +1 more source

Highlights in Pathophysiology of the Musculoskeletal System. [PDF]

Int J Mol Sci, 2023
Barone R, Szychlinska MA.
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Ultrashort Echo Time Quantitative Susceptibility Source Separation in Musculoskeletal System: A Feasibility Study. [PDF]

J Imaging
Sedaghat S, Park JI, Fu E, von Drygalski A, Ma Y, Chang EY, Du J, Nardo L, Jang H.   +8 more
europepmc   +1 more source

Study protocol: Accommodative effects on the musculoskeletal system. [PDF]

PLoS One, 2023
Zieliński G, Matysik-Woźniak A, Pająk B, Ginszt M, Rejdak R, Gawda P.   +5 more
europepmc   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Effects of Hypoglycemic Agents on The Musculoskeletal System: A Comprehensive Review. [PDF]

Drug Des Devel Ther
Zhao J, Lv SS, Lu Q, Cong XX, Zhang XF.
europepmc   +1 more source

Editorial: Impact and consequences of COVID-19 on the musculoskeletal system. [PDF]

Front Med (Lausanne), 2023
Toussirot E, Maglio M, Fini M, Salamanna F.   +3 more
europepmc   +1 more source

Distal clavicular osteolysis in a bodybuilder [PDF]

, 2018
Anisau, Aliaksandr, Vanhoenacker, Filip
core   +1 more source