Results 171 to 180 of about 4,040 (210)
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Synthesis of the Death-Cap Mushroom Toxin α-Amanitin
Journal of the American Chemical Society, 2018α-Amanitin is an extremely toxic bicyclic octapeptide isolated from the death-cap mushroom, Amanita phalloides. As a potent inhibitor of RNA polymerase II, α-amanitin is toxic to eukaryotic cells. Recent interest in α-amanitin arises from its promise as a payload for antibody-drug conjugates. For over 60 years, A. phalloides has been the only source of
Kaveh Matinkhoo +4 more
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Death-cap mushroom toxin synthesized
C&EN Global Enterprise, 2018α-Amanitin, a bicyclic octapeptide produced by the death-cap mushroom, is one of the deadliest known peptide toxins. Researchers are exploring antibody-drug conjugates of it as possible anticancer agents. “α-Amanitin has been the subject of thousands of published studies due to its exceptional toxicity,” says Steven L.
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Prophylaxis of cyanobacterial and mushroom cyclic peptide toxins.
The Journal of Pharmacology and Experimental Therapeutics, 1989The pathogenicity of virulent cyclic peptide toxins of the cyanobacterium, Microcystis aeruginosa, and the mushroom, Amanita phalloides, was prevented in mice by pretreatment with a variety of chemically unrelated agents including hydrocortisone, shellac, certain diazo and triazine dyes and cyclosporine. A.
W H, Adams +5 more
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Toxins and Psychoactive Compounds from Mushrooms
1996This chapter describes the toxic and/or hallucinogenic components of mushrooms obtained in pure form and chemically characterized up to now. Attempts to isolate the poisonous alkaloid of a fungus, the red fly agaric Amanita muscaria, were made almost 130 years ago.
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Rifampicin and cysteamine protect against the mushroom toxin phalloidin
Experientia, 1974Der Schutzefekt von Rifampicin gegen eine Letaldosis des Pilzgiftes Phalloidin wurde bestatigt und weiter charakterisiert. Auch Cysteamin erwies sich als wirksam. Keinen Schutz gegen Phalloidin boten Stoffe, welche das Pilzgift α-Amanitin antagonisieren. Die hepatotoxische Wirkungskomponente der meisten Phalloidin-Antagonisten wird erortert.
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Ribosomally Encoded Cyclic Peptide Toxins from Mushrooms
2012The cyclic peptide toxins of poisonous Amanita mushrooms are chemically unique among known natural products. Furthermore, they differ from other fungal cyclic peptides in being synthesized on ribosomes instead of by nonribosomal peptide synthetases. Because of their novel structures and biogenic origins, elucidation of the biosynthetic pathway of the ...
Jonathan D, Walton +2 more
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[Amanita phalloides toxins in dried mushrooms].
Casopis lekaru ceskych, 1993The content of toxins from Amanita phalloides in dried carpophores is decreasing in the dependence on time. The content of alpha-amanitin found after 20 years was about one half. A mere trace of alpha-amanitin which is the most stable of all toxins was detected in a carpophore 50 years old. Degradation of amatoxins and phallotoxins by light (mainly the
J, Klán, D, Baudisová
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[Hallucinogenic psilocybine containing mushrooms. Toxins contained in Danish wild mushrooms].
Ugeskrift for laeger, 1990A number of the wild Danish mushrooms contain the hallucinogenic agent psilocybin which resembles LSD in many ways. The commonest of these are the "liberty cap" or "magic mushrooms" (Psilocybe semilanceata). On the basis of experience from USA and western Europa, increase in employment of this mushrooms as a hallucinogenic intoxicant may be anticipated
J F, Lassen, H B, Ravn, S F, Lassen
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Toxin screening of (Agaricals, Basidiomycota): First report of phalloidin in Inocybaceae mushroom
Toxicon, 2022Yu-Guang Fan, Ya-Ya Yan, Yi-Zhe Zhang
exaly