Results 101 to 110 of about 352,627 (304)

Distinct interjoint coordination during fast alternate keystrokes in pianists with superior skill

open access: yesFrontiers in Human Neuroscience, 2011
Musical performance requires motor skills to coordinate the movements of multiple joints in the hand and arm over a wide range of tempi. However, it is unclear whether the coordination of movement across joints would differ for musicians with different ...
Shinichi eFuruya   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Musical Expertise and Second Language Learning

open access: yesBrain Sciences, 2013
Increasing evidence suggests that musical expertise influences brain organization and brain functions. Moreover, results at the behavioral and neurophysiological levels reveal that musical expertise positively influences several aspects of speech ...
Julie Chobert, Mireille Besson
doaj   +1 more source

Turkish folk music in Ghent: developing musical knowledge in a diaspora context [PDF]

open access: yes, 2010
The question of musical knowledge applied to folk music is always challenging. While folk music normally does not have great artistic or academic aspirations and its theory and praxis are often little documented, its musicians and public still possess ...
Sels, Liselotte
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Dancing to the same beat [PDF]

open access: yes, 2015
There is a longstanding historical and cultural relationship between Congo and Cuba via the slave trade and the ‘return’ of Cuban music to Africa. Do historic connections enable contemporary musicians from both worlds to recognise similarities in each ...
Mcguinness, Sara
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Injury profile of musicians in the Bloemfontein-based Free State symphony orchestra: a short report

open access: yesSouth African Journal of Physiotherapy, 2011
Similar  to  professional  athletes,  musicians  are  required  to perform optimally.  Few  studies  have  been  conducted  to  clarify  the  nature of injuries associated with musicians.
R. Barnes   +7 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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