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Insertional mutagenesis: Transposon-insertion libraries as mutagens in yeast
2002Publisher Summary Transposon-based insertional libraries are exceptionally useful as a means of screening for desired phenotypes and expression patterns. As compared to mutations generated by classical methods of chemical treatment and ultraviolet irradiation, transposon insertions are easy to identify: the transposon-encoded sequence serves as a ...
Anuj, Kumar +2 more
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Retroviral insertional mutagenesis: Tagging cancer pathways
2003Slow transforming retroviruses, such as the Moloney murine leukemia virus (M-MuLV), induce tumors upon infection of a host after a relatively long latency period. The underlying mechanism leading to cell transformation is the activation of proto-oncogenes or inactivation of tumor suppressor genes as a consequence of proviral insertions into the host ...
Harald, Mikkers, Anton, Berns
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Insertional Mutagenesis in Mouse Mammary Tumorigenesis
1991Over the past few years, several surprising discoveries have been made regarding cellular oncogenes which are activated in mouse mammary tumors. These genes provide a particularly good example of the theme of this volume: host cell oncogenes activated by insertion of proviral DNA.
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Random Insertional Mutagenesis in Arabidopsis
2002Arabidopsis thaliana is now recognized as a model organism for research in plant biology, especially genetics and molecular biology, and is used for the functional analyses of various genes. However, accumulation of genomic and expressed sequence tag (EST) DNA sequence data (Lin et al., 1999; Mayer et al.,1999; Hofte et al.,1993; Newman et al.,1994 ...
Takuyo Ito, Kazuo Shinozakil
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Insertional Mutagenesis and Mouse Development
1992Classical genetic analysis of spontaneous or induced mutations has identified a number of candidate developmental genes. Further analysis of mutant phenotypes has helped define possible functions for many of these genes. However, to complete our understanding of their roles in development, an extensive molecular genetic analysis will ultimately be ...
Michael R. Kuehn, Jonathan P. Stoye
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Insertional mutagenesis and breast carcinoma
Nature, 1988G, Rechavi, N, Katzir, D, Givol
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