Results 231 to 240 of about 664,651 (329)

Retraction Note: Enhancement of novel Endo-polygalacturonase expression in Rhodotorula mucilaginosa PY18 : insights from mutagenesis and molecular docking. [PDF]

Microb Cell Fact
El-Aziz NMA, Moharam ME, El-Gamal NN, Khalil BE.   +3 more
europepmc   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Lethal mutagenesis and the transient within-host dynamics of viral adaptation. [PDF]

Virus Evol
Guillemet M, Martin G, Hardy E, Roze D, Gandon S.   +4 more
europepmc   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Screening, Characterization and Mutagenesis Breeding of <i>Monascus</i> Isolates with High Esterification Activity. [PDF]

Foods
Zhou C, Yang S, Zhu X, Li X, Li J, Lu Z.
europepmc   +1 more source

Site-directed mutagenesis studies on tyrosyl-tRNA sythetase

, 1984
Anthony J. Wilkinson
openalex   +1 more source

Mutagenesis of the Neisseria gonorrhoeae porin reduces invasion in epithelial cells and enhances phagocyte responsiveness

, 1999
Frank J. Bauer, Thomas Rüdel, Markus Stein, Thomas F. Meyer   +3 more
openalex   +2 more sources

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Differential roles of Rad18 in repressing carcinogen- and oncogene-driven mutagenesis <i>in vivo</i>. [PDF]

NAR Cancer
Anand JR, Brown BW, Lou J, Gu Q, Yang Y, Droby G, Wu D, Jena A, Xie J, Fedoriw Y, Weissman B, Williams S, Vaziri C.   +12 more
europepmc   +1 more source

The role of exonucleolytic processing and polymerase-DNA association in bypass of lesions during replication in vitro. Significance for SOS-targeted mutagenesis.

, 1988
Hasia Shwartz, O Shavitt, Zvi Livneh
openalex   +1 more source