Results 91 to 100 of about 73,404 (345)

A FAIR platform for reproducing mutational signature detection on tumor sequencing data [PDF]

arXiv, 2023
This paper presents a portable, privacy-preserving, in-browser platform for the reproducible assessment of mutational signature detection methods from sparse sequencing data generated by targeted gene panels. The platform aims to address the reproducibility challenges in mutational signature research by adhering to the FAIR principles, making it ...
arxiv  

Food Mutagens [PDF]

The Journal of Nutrition, 2003
Several lines of evidence indicate that diet and dietary behaviors can contribute to human cancer risk. One way that this occurs is through the ingestion of food mutagens. Sporadic cancers result from a gene-environment interactions where the environment includes endogenous and exogenous exposures.
Radoslav, Goldman, Peter G, Shields
openaire   +2 more sources

Transgenerational Reproductive and Developmental Toxicity Induced by N‐Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster

Journal of Applied Toxicology, Volume 45, Issue 5, Page 841-857, May 2025.
ABSTRACT N‐Nitrosodimethylamine (NDMA) is a known water disinfection byproduct (DBP) characterized as a potent hepatotoxin, promutagen, and probable human carcinogen; this is because of the metabolites associated with its biotransformation. The metabolism of NDMA produces formaldehyde, another alkylating agent and DBP. Both compounds are generated from
Oscar Eduardo Tabares‐Mosquera, Javier Andrés Juárez‐Díaz, Rafael Camacho‐Carranza, Patricia Ramos‐Morales   +3 more
wiley   +1 more source

Use of high throughput sequencing to observe genome dynamics at a single cell level [PDF]

, 2009
With the development of high throughput sequencing technology, it becomes possible to directly analyze mutation distribution in a genome-wide fashion, dissociating mutation rate measurements from the traditional underlying assumptions. Here, we sequenced several genomes of Escherichia coli from colonies obtained after chemical mutagenesis and observed ...
arxiv   +1 more source

Induced floral heteromorphism in Petunia hybrida

Acta Societatis Botanicorum Poloniae, 2014
Floral heteromorphism induced in Petunia hybrida with several chemical mutagens and gamma-radiation is discussed. Potentials of these mutagens in inducing various forms are described.
S. G. Kashikar, A. S. Khalatkar
doaj   +1 more source

Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste incineration, using the comet and micronucleus tests on amphibian (Xenopus laevis) larvae and bacterial assays (MutatoxR and Ames tests) [PDF]

, 2006
The management of contaminated soils and wastes is a matter of considerable human concern. The present study evaluates the genotoxic potential of aqueous extracts of two soils (leachates) and of bottom ash resulting from municipal solid waste ...
Devaux, Alain, Ferrier, Vincent, Gauthier, Laury, Jourdain, Marie-José, Mailhes, Corinne, Mouchet, Florence, Triffault, Gaëlle   +6 more
core   +1 more source

Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human mesenchymal stem/stromal cells (hMSCs) can differentiate into mesoderm‐type cells, making them suitable candidates for tissue repair therapies. However, their relatively low frequency in adult tissue necessitates ex vivo expansion prior to regenerative medicine applications, and therefore, long‐term hMSC genetic stability during ...
Marc A. Beal, Melanie Coughlan, Andrée Nunnikhoven, Reena Corbane, Cathy Cummings‐Lorbetskie, Andrea Rowan‐Carroll, Tanvi Sharma, Andrew Williams, Jessie R. Lavoie, Andrew Stalker, Asish Mohapatra, Matthew J. Meier   +11 more
wiley   +1 more source

Antimutagenic effect of genistein

Czech Journal of Food Sciences, 2006
A great variety of health benefits including the protection against breast and prostate cancers has been attributed to the soya consumption, because of the presence of soy beans isoflavones, genistein, and others. We investigated the antigenotoxic effect
Zdeňka Polívková, Martina Langová, Petr Šmerák, Jiřina Bártová, Ivo Bárta   +4 more
doaj   +1 more source

Allergenicity, Genotoxicity and Subchronic Toxicity Assessment of IgG Binding Protein LT Produced From Aspergillus oryzae

Journal of Applied Toxicology, EarlyView.
ABSTRACT Gastrointestinal health is one of the fastest growing areas in the food and beverage industry, as its importance to overall health and well‐being is becoming increasingly recognized. Immunoglobulins play a key role in protecting the gastrointestinal tract, and nonbovine sources of immunoglobulins (including camel milk, which has a long history
Kirt R. Phipps, Sachin Patel, Kevin Scaife, Toby Holmes, Alica Šoltésová, Sandra Wingaard Thrane, Louise Kristine Vigsnæs, Nigel Baldwin, Christel Jørgensen   +8 more
wiley   +1 more source

Seagrass Posidonia oceanica (L.) Delile as a marine biomarker: A metabolomic and toxicological analysis [PDF]

, 2018
A human-made environmental disaster due to the shipwrecked of Costa Concordia cruise vessel on the Tuscan Island of Giglio (Italy) coast and the possible pollutants release has been feared, so requiring the activation of removal operations and the ...
Agostini, Ardizzone, Beck, Bitam, Boudouresque, Cannac, Dalla Via, Del Moral, Del Serrone, Di Sotto, Di Sotto, Di Sotto, Di Sotto, Dumay, Díaz, Farah, Fitzpatrick, Fonseca, Francour, Gacia, Gacia, Grace, Greco, Heglmeier, Jones, Kuo, Lassauque, Maestrini, Maggi, Moglia, Mollica, Montefalcone, Nicoletti, Nicoletti, Pérez, Reich, Richir, Ruiz, Sager, Toniolo   +39 more
core   +1 more source