Results 71 to 80 of about 26,211 (229)
ChemistryOpen, Volume 15, Issue 9, September 2026.Integrated in silico discovery of thymoquinone analogs as potent Keap1 inhibitors for ALS therapy. Using validated QSAR, docking, and 200 ns MD simulations, we identified brain‐penetrant leads (CHEMBL3416163, CHEMBL4636830, and CHEMBL221598) with binding affinities up to fourfold stronger than thymoquinone, offering a targeted strategy to restore redox
Jabir C. Nalicho +3 more
wiley +1 more source
Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.Rational Design, Synthesis, Biological Evaluation, and In Silico Investigation of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐yl) Derivatives as EGFR Inhibitors Targeting Wild‐Type and Mutant EGFR in NSCLC. ABSTRACT Non‐small cell lung cancer (NSCLC), driven by mutations in the epidermal growth factor receptor ...
Rohit Pal +6 more
wiley +1 more source
EFSA Journal, Volume 24, Issue 9, September 2026.Abstract The EFSA Panel on Food Additives and Flavourings (FAF Panel) provides a scientific opinion on the safety of a modified manufacturing process for the food additive enzymatically produced steviol glycosides (E 960c). The new process converts purified steviol glycosides extracted from Stevia rebaudiana leaves through enzymatic bioconversion ...
EFSA Panel on Food Additives and Flavourings (FAF) +29 more
wiley +1 more source
Mutagens affect food and water biodeteriorating fungi [PDF]
, 2015 Many areas of food mycology could be affected detrimentally by mutation of wild type fungi. Some of these will contact mutagens from pre-isolation to experimentation and the effect on fungi isolated from mycotoxin-contaminated food is assessed for ...
Lima, Nelson, Paterson, R. R. M.
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, 2022 BackgroundClinical and preclinical studies suggested that certain mutagens occurring as a reaction of creatine, amino acids, and sugar during the high temperature of cooking meat are involved in the pathogenesis of human cancer.
Qie Reng (13846903) +6 more
core +1 more source
Re‐evaluation of salt of aspartame‐acesulfame (E 962) as food additive
EFSA Journal, Volume 24, Issue 9, September 2026.Abstract The present opinion deals with the re‐evaluation of salt of aspartame‐acesulfame (E 962) as a food additive. The Panel considered that upon ingestion, E 962 dissociates into aspartame and acesulfame ions which correspond to those of the authorised sweeteners aspartame (E 951) and acesulfame K (E 950). The Panel therefore assessed the safety of
EFSA Panel on Food Additives and Flavourings (FAF) +34 more
wiley +1 more source
, 2005 Few reports have characterized mutagenic compounds in respirable airborne particles (
Taghizadeh, Koli +5 more
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The FASEB Journal, Volume 40, Issue 16, 31 August 2026.The zinc transporter ZIP1 is induced promptly following treatment with the DNA damage agent bleomycin through the TNFα–NF‐κB pathway. NF‐κB accumulates in the nucleus and upregulates the transcription of SLC39A1, the coding gene for ZIP1. The increased expression of ZIP1 leads to elevated intracellular zinc levels, which, in turn, enhance the DNA ...
Zichong Li +4 more
wiley +1 more source
Antimutagenic properties of goat's probiotic against mutagens
, 2013 Gastrointestinal tract microbial ecology has an important effect on goat health and performance. Mutagens are frequently formed during stress or bacterial gastrointestinal infections and by endogenous microflora. The ability of goat´s probiotic to reduce
Arena, Mario Eduardo +3 more
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Avaliação do potencial genotóxico de uma mina de urânio abandonada [PDF]
, 2007 Mestrado em Biologia Molecular e CelularUm dos principais problemas associados a locais contaminados, como áreas de extracção de minérios metálicos, corresponde à possível contaminação de águas superficiais e subterrâneas, por escorrência e/ou ...
Neves, Maria de Fátima de Jesus Vieira das
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