Results 51 to 60 of about 49,008 (223)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Analysis of induced genetic variability for morphological and floral characters with male sterility in sesame (Sesamum indicum L.)

Electronic Journal of Plant Breeding, 2018
Male sterility can be useful to obtain high yielding sesame hybrids with reduced cost and labour. It can be induced artificially into the released cultivars by using chemical mutagens.
M. Imran, M. Dash, T. R. Das and, M. Kabi   +3 more
doaj   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Environmental mutagens may be implicated in the emergence of drug-resistant microorganisms.

FEMS Microbiology Letters, 2011
The emergence of drug-resistant microorganisms is an important medical and social problem. Drug-resistant microorganisms are thought to grow selectively in the presence of antibiotics. Most clinically isolated drug-resistant microorganisms have mutations
Emiko Miyahara, Makiko Nishie, Shota Takumi, H. Miyanohara, J. Nishi, K. Yoshiie, H. Oda, M. Takeuchi, M. Komatsu, Kohji Aoyama, M. Horiuchi, T. Takeuchi   +11 more
semanticscholar   +1 more source

Ethyl Methanesulfonate (EMS) Mutagen Toxicity-Induced DNA Damage, Cytosine Methylation Alteration, and iPBS-Retrotransposon Polymorphisms in Wheat (Triticum aestivum L.)

Agronomy, 2023
The use of mutagens in plant breeding is used to create new germplasm, increase agricultural yield, quality, and resistance to diseases and pests. Mutagens are physical or chemical factors that can alter the DNA or RNA structure of an organism, causing ...
Aras Türkoğlu, Kamil Haliloğlu, Metin Tosun, Henryk Bujak, Barış Eren, Fatih Demirel, Piotr Szulc, Halit Karagöz, Marek Selwet, Güller Özkan, Gniewko Niedbała   +10 more
doaj   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Induction of genetic variability in oat [PDF]

Crop Breeding and Applied Biotechnology, 2007
Genetic variability in plants can be maximized through techniques of induction to make selection of genotypeswith improved adaptation to cultivation conditions possible.
Jefferson Luis Meirelles Coimbra, Daniel Schwantes, Juliano Garcia Bertoldo, Mauricio Marini Kopp   +3 more
doaj  

Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Duplex Sequencing (DS) is an ultra‐accurate, error‐corrected next generation sequencing (ecNGS) technology for mutation analysis. A working group (WG) within Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee is investigating the suitability of ecNGS for regulatory mutagenicity testing, using DS as a model ...
Shaofei Zhang, Barbara L. Parsons, Devon Fitzgerald, Anne Ashford, James Todd Auman, Tao Chen, Annette Dodge, Azeddine Elhajouji, Lena Pfaller, Shawn Harris, Jake Higgins, Cheryl A. Hobbs, Francesco Marchetti, Matthew J. Meier, Meagan B. Myers, Jesse Salk, Rebecca Sahroui, David Schuster, Raja Settivari, Stephanie L. Smith‐Roe, Carole L. Yauk, Jian Yan, Andrew Williams, Connie L. Chen   +23 more
wiley   +1 more source

Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.

Toxicological Sciences, 2010
An in vivo mutation assay has been developed based on flow cytometric enumeration of glycosylphosphatidylinositol (GPI) anchor-deficient rat erythrocytes.
S. Phonethepswath, D. Franklin, D. Torous, Steven M. Bryce, J. Bemis, Sarojini Raja, Svetlana L. Avlasevich, P. Weller, O. Hyrien, J. Palis, J. T. Macgregor, S. Dertinger   +11 more
semanticscholar   +1 more source

Seed viability, germination and seedling growth of canola ( Brassica napus L.) as influenced by chemical mutagens

, 2011
Mutation induction is considered as an effective way to enrich plant genetic variation, particularly for traits with a very low level of genetic variation. The objectives of this study were to evaluate the effect of different dosages of chemical mutagens
P. Nathan, X. Rathinam, Marimuthu Kasi, Z. A. Rahman, S. Subramaniam   +4 more
semanticscholar   +2 more sources