Results 81 to 90 of about 53,897 (283)

Genome Editing Technologies to Improve Health‐Related Phytocompounds in Crops

Food Frontiers, EarlyView.
ABSTRACT Due to rapid global population growth and the resulting significant increase in food demand, the world is facing an epidemic of malnutrition. Although yield improvement remains one of the main targets of breeding programs, much attention is being paid to the nutritional aspects of crops, including nutrients and bioactive compounds that are ...
Maria Dellino, Claudio de Giovanni, Monica Marilena Miazzi, Cinzia Montemurro, Domenica Nigro   +4 more
wiley   +1 more source

Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.

Toxicological Sciences, 2010
An in vivo mutation assay has been developed based on flow cytometric enumeration of glycosylphosphatidylinositol (GPI) anchor-deficient rat erythrocytes.
S. Phonethepswath, D. Franklin, D. Torous, Steven M. Bryce, J. Bemis, Sarojini Raja, Svetlana L. Avlasevich, P. Weller, O. Hyrien, J. Palis, J. T. Macgregor, S. Dertinger   +11 more
semanticscholar   +1 more source

Efficacy of Haloxyfop‐R‐Methyl on Allium cepa: Cyto‐Genotoxic and In Silico Docking Studies on the Mechanism of Action

Microscopy Research and Technique, EarlyView.
ABSTRACT Haloxyfop‐R‐methyl (HRM) is extensively employed to control annual and perennial grass weeds. This study aimed to investigate the cyto‐genotoxic effects of HRM at concentrations of 1.19, 2.38, and 4.76 mg/L over various time intervals (24, 48, 72, and 96 h) on Allium cepa root.
Recep Liman, Emine Kılıç, Erman Salih İstifli, Yudum Yeltekin Uğur, İbrahim Hakkı Ciğerci   +4 more
wiley   +1 more source

A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals. [PDF]

, 2019
A database of 91 chemicals with published data from both transgenic rodent mutation (TGR) and rodent comet assays has been compiled. The objective was to compare the sensitivity of the two assays for detecting genotoxicity.
Aardema, MJ, Beevers, C, Bhalli, J, Douglas, GR, Escobar, PA, Farabaugh, CS, Guerard, M, Johnson, GE, Kirkland, D, Kulkarni, R, Le Curieux, F, LeBaron, MJ, Levy, DD, Long, AS, Lott, J, Lovell, DP, Luijten, M, Marchetti, F, Nicolette, JJ, Pfuhler, S, Roberts, DJ, Stankowski, LF, Thybaud, V, Weiner, SK, Williams, A, Witt, KL, Young, R   +26 more
core   +3 more sources

Induction of genetic variability in oat [PDF]

Crop Breeding and Applied Biotechnology, 2007
Genetic variability in plants can be maximized through techniques of induction to make selection of genotypeswith improved adaptation to cultivation conditions possible.
Jefferson Luis Meirelles Coimbra, Daniel Schwantes, Juliano Garcia Bertoldo, Mauricio Marini Kopp   +3 more
doaj  

Spectrum and Density of Gamma and X-ray Induced Mutations in a Non-Model Rice Cultivar

Plants, 2022
Physical mutagens are a powerful tool used for genetic research and breeding for over eight decades. Yet, when compared to chemical mutagens, data sets on the effect of different mutagens and dosages on the spectrum and density of induced mutations ...
Joanna Jankowicz-Cieslak, Bernhard J. Hofinger, Luka Jarc, Sini Junttila, Bence Galik, Attila Gyenesei, Ivan L. Ingelbrecht, Bradley J. Till   +7 more
doaj   +1 more source

On the origins of the Omicron variant of the SARS-CoV-2 virus [PDF]

arXiv, 2021
A possible explanation based on first principles for the appearance of the Omicron variant of the SARS-CoV-2 virus is proposed involving coinfection with HIV. The gist is that the resultant HIV-induced immunocompromise allows SARS-CoV-2 greater latitude to explore its own mutational space.
arxiv  

Gender-related differences in response to mutagens and carcinogens.

Mutagenesis, 2010
The incidences of many cancers can be very different in men and women. Besides differences in exposures to putative causative agents, it is plausible that both genetic and epigenetic effects play roles in these differences.
Micheline Kirsch-Volders, Stefano Bonassi, Z. Herceg, Ari Hirvonen, Lennart Möller, David H. Phillips   +5 more
semanticscholar   +1 more source

Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy

Small Science, EarlyView.
Autophagy modulation holds promise for enhancing cancer treatment, yet clinical translation remains challenging. This review explores nanomedicine‐based strategies to improve autophagy‐targeting drugs, highlighting their synergy with chemotherapy, immunotherapy, phototherapy, and gene therapy. It also discusses nanoparticle design and clinical progress,
Sohaib Mahri, Rodolfo Villa, Ya‐Ping Shiau, Menghuan Tang, Kelsey Jane Racacho, Qiufang Zong, Saiful Islam Chowdhury, Tan Hua, Felipe Godinez, Andrew Birkeland, Tzu‐Yin Lin, Yuanpei Li   +11 more
wiley   +1 more source

Controlled biotechnological production of polyhydroxyalkanoates [PDF]

, 2012
Předložená diplomová práce se zabývá produkcí polyhydroxyalkanoátů (PHA) bakterií Cupriavidus necator H16. Cílem práce byla příprava, selekce a charakterizace mutantních kmenů schopných vyšší produkce PHA.
Šnajdar, Ondřej
core