Results 91 to 100 of about 291 (106)

Poly(ethylene imine) Nanocarriers Do Not Induce Mutations nor Oxidative DNA Damage in Vitro in MutaMouse FE1 Cells

Molecular Pharmaceutics, 2011
Genotoxicity information on polymers used for gene delivery is scant, but of great concern, especially when developing polymeric nanocarriers as nonviral vector systems for cancer treatment. The genotoxicity of some engineered nanomaterials, e.g., metal oxides like ZnO, TiO₂, and CuO but also carbon based materials like carbon black or nanotubes, has ...
Andrea, Beyerle, Alexandra S, Long, Paul A, White, Thomas, Kissel, Tobias, Stoeger   +4 more
openaire   +2 more sources

Toxicity Profile of Benzo[a]pyrene in the MaleLacZTransgenic Mouse (MutaMouse) Following Oral Administration for 5 Consecutive Days

Regulatory Toxicology and Pharmacology, 1998
The toxicity profile of benzo[a]pyrene (BP) was examined in the MutaMouse. The transgenic mouse integrated with lambda gt10 lacZ vectors is used worldwide as an experimental animal in in vivo mutagenesis testing systems. There are few toxicity studies including carcinogenicity in the MutaMouse, and so far only a few carcinogenicity studies of BP ...
A, Hakura, J, Sonoda, Y, Tsutsui, T, Mikami, T, Imade, M, Shimada, S, Yaguchi, M, Yamanaka, M, Tomimatsu, K, Tsukidate   +9 more
openaire   +2 more sources

Mutagenicity of 4-nitroquinoline 1-oxide in the Muta™Mouse

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1999
As part of a collaborative study, the Mammalian Mutagenesis Study Group (MMS), a sub-organization of the Environmental Mutagen Society of Japan (JEMS) conducted mutagenicity tests in MutaMouse. Using a positive selection method, we studied the organ-specificity and time dependence of mutation induction by 4-nitroquinoline 1-oxide (4NQO).
M, Nakajima, M, Kikuchi, K, Saeki, Y, Miyata, M, Terada, F, Kishida, R, Yamamoto, C, Furihata, S W, Dean   +8 more
openaire   +2 more sources

In vivo genotoxicity evaluation of dimethylarsinic acid in Muta™Mouse

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2002
Dimethylarsinic acid (DMA) induces DNA damage in the lung by formation of various peroxyl radical species. The present study was conducted to evaluate whether arsenite or its metabolite, DMA, could initiate carcinogenesis via mutagenic DNA lesions in vivo that can be attributed to oxidative damage.
Yasuhiro, Noda, Takayoshi, Suzuki, Arihiro, Kohara, Akira, Hasegawa, Toshihisa, Yotsuyanagi, Makoto, Hayashi, Toshio, Sofuni, Kenzo, Yamanaka, Shoji, Okada   +8 more
openaire   +2 more sources

Performance of the in vitro transgene mutation assay in MutaMouse FE1 cells: Evaluation of nine misleading (“False”) positive chemicals

Environmental and Molecular Mutagenesis, 2017
The screening of chemicals for the protection of human health and the environment requires the assessment of genetic toxicity. However, existing, internationally‐accepted in vitro mammalian genotoxicity tests have been criticized for their low specificity (i.e.
Rebecca M, Maertens, Alexandra S, Long, Paul A, White   +2 more
openaire   +2 more sources

The LacZ transgene in mutaTM Mouse maps to chromosome 3

Mutation Research Letters, 1994
Transgenic mouse models are being used with increasing frequency for mutational and toxicological studies. One such system. MutaMouse, contains a stably integrated lambda-gt10LacZ shuttle vector in the mouse genome. We describe the use of dual color fluorescence in situ hybridization (FISH) with Mus musculus whole chromosome paints and lambda DNA to ...
R R, Swiger, B, Myhr, J D, Tucker
openaire   +2 more sources

Mutagenicity of aristolochic acid in the lambda/lacZ transgenic mouse (Muta™Mouse)

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2002
Aristolochic acid (AA) is found in a plant that causes urothelial carcinomas in patients with Chinese herb nephropathy (CHN). To evaluate the in vivo mutagenicity of AA, we analysed the mutant frequency (MF) in the lacZ and cII gene of 10 organs of the lambda/lacZ transgenic mouse (MutaMouse) after intragastric treatment with AA (15mg/kg per week x 4).
Arihiro, Kohara, Takayoshi, Suzuki, Masamitsu, Honma, Tomohiko, Ohwada, Makoto, Hayashi   +4 more
openaire   +2 more sources

Diesel exhaust particles are mutagenic in FE1-Muta™Mouse lung epithelial cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2008
The particulate phase of diesel engine exhaust is likely carcinogenic. However, the mechanisms of diesel exhaust particles (DEPs) induced mutagenicity/carcinogenicity are still largely unknown. We determined the mutant frequency following eight repeated 72 h incubations with 37.5 or 75 microg/ml DEP (NIST SRM 1650) in the FE1-MutaMouse lung epithelial ...
Jacobsen, Nicklas Raun, Møller, Peter, Cohn, Corey Alexander, Loft, Steffen, Vogel, Ulla, Wallin, Håkan   +5 more
openaire   +3 more sources

Mutation induction by N-propyl-N-nitrosourea in eight Muta™Mouse organs

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1999
As a part of the 2nd Collaborative Study for the Transgenic Mouse Mutation Assay, we studied the organ specificity and the temporal changes in mutant frequency (MF) of the lacZ gene following intraperitoneal injection of 250 mg/kg N-propyl-N-nitrosourea into male MutaMouse.
T, Hara, K, Hirano, N, Hirano, H, Tamura, H, Sui, T, Shibuya, A, Hyogo, T, Hirashio, H, Tokai, Y, Yamashita, K, Kura   +10 more
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Tissue‐specific metabolic activation and mutagenicity of 3‐nitrobenzanthrone in Muta™Mouse

Environmental and Molecular Mutagenesis, 2008
Abstract3‐Nitrobenzanthrone (3‐NBA) is a mutagen and suspected human carcinogen detected in diesel exhaust, airborne particulate matter, and urban soil. We investigated the tissue specific mutagenicity of 3‐NBA at the lacZ locus of transgenic Muta™Mouse following acute single dose or 28‐day repeated‐dose oral administration.
Guosheng, Chen, John, Gingerich, Lynda, Soper, George R, Douglas, Paul A, White   +4 more
openaire   +2 more sources