Results 11 to 20 of about 1,846,603 (258)

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome [PDF]

, 2009
Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons.
Aiken, Ali Khoshnan, Alice L. Lau, Ana Maria Cuervo, Anne, Apostol, Arrasate, Arrasate, Ashish Massey, Atwal, Atwal, Björkqvist, Brown, Charity T. Aiken, Chen, Chondrogianni, Cornett, Cuervo, Cuervo, Cuervo, D'Orazi, Dan, Donald C. Lo, Fang, Finkbeiner, Frank M. LaFerla, Gillian Bates, Graham, Grossman, Gu, Guerrero, Gutekunst, Hasan Khashwji, Henn, Hernandez-Hernandez, Hietakangas, Hofmann, Hu, Huang, Humbert, Hunter, J. Lawrence Marsh, Jacqueline Gire O'Rourke, Jeong, Jiang, Joan S. Steffan, Karin, Karin, Katalin Illes, Kaushik, Kazantsev, Khoshnan, Khoshnan, Kim N. Green, Komatsu, Lan Huang, Leslie Michels Thompson, Linda S. Kaltenbach, Liu, Lo, Luo, Mangiarini, Marta Martinez-Vincente, Martinez-Vicente, Massey, Massey, Michael R. Hayden, Michels, Mizushima, Montserrat Arrasate, Namita Agrawal, Orr, Paul H. Patterson, Peters-Libeu, Rockabrand, Saudou, Schilling, Scott O. Zeitlin, Shao, Southwell, Steffan, Steffan, Steffan, Steven Finkbeiner, Tagwerker, Tamas Lukacsovich, Tonoki, Verma, Walker, Warby, Warby, Warby, Wu, Xia, Ya-Zhen Zhu, Yanai, Zhang, Zuccato   +97 more
core   +3 more sources

Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats [PDF]

, 2018
Mutations in ubiquilin2 (UBQLN2) have been linked to abnormal protein aggregation in amyotrophic lateral sclerosis (ALS). The mechanisms underlying UBQLN2-related neurodegenerative diseases remain unclear.
Chen, Tianhong, Gao, Limo, Huang, Bo, Huang, Cao, Shi, Xinglong   +4 more
core   +2 more sources

Characterisation of a pucBA deletion mutant from Rhodopseudomonas palustris lacking all but the pucBAd genes [PDF]

, 2017
Rhodopseudomonas palustris is a species of purple photosynthetic bacteria that has a multigene family of puc genes that encode the alpha and beta apoproteins, which form the LH2 complexes.
Carey, Anne-Marie, Cogdell, Richard J., de Percin Northumberland, Claire Ortmann, Gardiner, Alastair T., Henry, Sarah L., Kelly, Sharon M., Mullen, William, Roszak, Aleksander W., Southall, June   +8 more
core   +1 more source

Vulnerability Mimicking Mutants [PDF]

arXiv, 2023
With the increasing release of powerful language models trained on large code corpus (e.g. CodeBERT was trained on 6.4 million programs), a new family of mutation testing tools has arisen with the promise to generate more "natural" mutants in the sense that the mutated code aims at following the implicit rules and coding conventions typically produced ...
arxiv  

Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials [PDF]

, 2006
Recent studies suggest that the toxicity of familial amyotrophic lateral sclerosis mutant Cu, Zn superoxide dismutase (SOD1) arises from its selective recruitment to mitochondria. Here we demonstrate that each of 12 different familial ALS-mutant SOD1s
Butler Gralla, Edith, Carrì, Maria Teresa, Casciati, Arianna, Cozzolino, Mauro, Crosio, Claudia, Ferri, Alberto, Nencini, Monica, Rotilio, Giuseppe, Valentine, Joan Selverstone   +8 more
core   +2 more sources

Keeping Mutation Test Suites Consistent and Relevant with Long-Standing Mutants [PDF]

arXiv, 2022
Mutation testing has been demonstrated to be one of the most powerful fault-revealing tools in the tester's tool kit. Much previous work implicitly assumed it to be sufficient to re-compute mutant suites per release. Sadly, this makes mutation results inconsistent; mutant scores from each release cannot be directly compared, making it harder to measure
arxiv  

Source Code Optimization using Equivalent Mutants [PDF]

, 2018
A mutant is a program obtained by syntactically modifying a program's source code; an equivalent mutant is a mutant, which is functionally equivalent to the original program. Mutants are primarily used in \emph{mutation testing}, and when deriving a test suite, obtaining an equivalent mutant is considered to be highly negative, although these ...
arxiv   +1 more source

Mutation Testing in Evolving Systems: Studying the relevance of mutants to code evolution [PDF]

arXiv, 2021
When software evolves, opportunities for introducing faults appear. Therefore, it is important to test the evolved program behaviors during each evolution cycle. We conduct an exploratory study to investigate the properties of commit-relevant mutants, i.e., the test elements of commit-aware mutation testing, by offering a general definition and an ...
arxiv  

Genetic Dissection of the Drosophila Nervous System by means of Mosaics [PDF]

, 1970
Given a mutant having abnormal behavior, the anatomical domain responsible for the deficit may be identified by the use of genetic mosaicism. Individuals may be produced in which a portion of the body is mutant male while the rest is normal female.
Benzer, Seymour, Hotta, Yoshiki
core   +1 more source

Detailed kinship estimation for detecting bias among breeding families in a reintroduced population of the endangered bagrid catfish Tachysurus ichikawai

Population Ecology, EarlyView.
In the process of captive breeding and reintroduction of endangered animal species, it is crucial to minimize familial bias in reproductive success during the reintroduction phase to preserve genetic diversity. In this study, we attempted to identify the familial lineage of individuals of the endangered bagrid fish Tachysurus ichikawai born at the ...
Hinano Mizuno, Kouji Nakayama, Tetsuya Akita, Yasuyuki Hashiguchi, Tomonori Osugi, Hirohiko Takeshima   +5 more
wiley   +1 more source