Results 11 to 20 of about 2,692,923 (420)
On the establishment of a mutant [PDF]
Journal of Mathematical Biology, 2020 AbstractHow long does it take for an initially advantageous mutant to establish itself in a resident population, and what does the population composition look like then? We approach these questions in the framework of the so called Bare Bones evolution model (Klebaner et al. in J Biol Dyn 5(2):147–162, 2011.https://doi.org/10.1080/17513758.2010.506041)
Jeremy Baker +3 more
openaire +5 more sources
Targeting mutant p53 for cancer therapy: direct and indirect strategies
Journal of Hematology & Oncology, 2021 TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 protein oncogenic properties.
Jiahao Hu +9 more
semanticscholar +1 more source
Brain Sciences, 2021 Acquisition of detailed anatomical and molecular knowledge from intact biological samples while preserving their native three-dimensional structure is still a challenging issue for imaging studies aiming to unravel a system’s functions. Three-dimensional
Olga Ermakova +12 more
doaj +1 more source
Cell, 2017 The development of CRISPR/Cas9-mediated gene knockout in two ant species opens a new window into exploring how social insects use olfactory cues to organize their collective behavior.
Daniel A. Friedman +3 more
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An entropy-based method to measure phase-locking between LFP and spikes
AIP Advances, 2023 Phase-locking between local field potential and spikes has been widely investigated through neurophysiological analysis. Two indices most frequently adopted traditionally include the mean resultant length and p of the Rayleigh test.
Xing-Yan Dang +6 more
doaj +1 more source
The contribution of maternal oral, vaginal, and gut microbiota to the developing offspring gut
Scientific Reports, 2023 There is limited understanding of how the microbiota colonizing various maternal tissues contribute to the development of the neonatal gut microbiota (GM). To determine the contribution of various maternal microbiotic sites to the offspring microbiota in
Amber L. Russell +6 more
doaj +1 more source
Study on the multiple characteristics of M3 generation of pea mutants obtained by neutron irradiation [PDF]
Nuclear Science and Techniques, 2020,31:67, 2021 Irradiation breeding is an important technique in the effort to solve food shortages and improve the quality of agricultural products. In this study, a field test was implemented on the M3 generation of two mutant pea plants gained from previous neutron radiation of pea seeds. The relationship between agronomic characteristics and yields of the mutants
arxiv +1 more source
Mutant HER2 needs mutant HER3 to be an effective oncogene [PDF]
Cell Reports Medicine, 2021 Hanker et al. reveal that co-occurring missense mutations in the human epidermal growth factor receptor 2 (HER2) and its catalytically inactive homolog HER3 synergize to promote oncogenic signaling by the HER2/HER3 complex.
Natalia Jura +2 more
openaire +3 more sources
HOE DOORDACHT OM TE GAAN MET ETHISCHE VRAAGSTUKKEN?
Journal of Social Intervention: Theory and Practice, 2020 “Als sociaal werker word je, bij de uitoefening van je vak, onvermijdelijk geconfronteerd met te nemen beslissingen. Beslissingen die niet enkel gestoeld zijn op theoretische inzichten, methodische ervaringen, correcte toepassingen van regels en codes ...
Fuusje de Graaff
doaj +1 more source
Connexin Mutants and Cataracts [PDF]
Frontiers in Pharmacology, 2013 The lens is a multicellular, but avascular tissue that must stay transparent to allow normal transmission of light and focusing of it on the retina. Damage to lens cells and/or proteins can cause cataracts, opacities that disrupt these processes.
Viviana M. Berthoud +2 more
openaire +4 more sources