Results 11 to 20 of about 2,114,568 (336)
Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. [PDF]
, 2012 Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53 ...
Durkovic, Marina +13 more
core +17 more sources
On the establishment of a mutant [PDF]
Journal of Mathematical Biology, 2020 AbstractHow long does it take for an initially advantageous mutant to establish itself in a resident population, and what does the population composition look like then? We approach these questions in the framework of the so called Bare Bones evolution model (Klebaner et al. in J Biol Dyn 5(2):147–162, 2011.https://doi.org/10.1080/17513758.2010.506041)
Jeremy Baker +3 more
openaire +5 more sources
Cell, 2017 The development of CRISPR/Cas9-mediated gene knockout in two ant species opens a new window into exploring how social insects use olfactory cues to organize their collective behavior.
Daniel A. Friedman +3 more
openaire +3 more sources
Mutant HER2 needs mutant HER3 to be an effective oncogene [PDF]
Cell Reports Medicine, 2021 Hanker et al. reveal that co-occurring missense mutations in the human epidermal growth factor receptor 2 (HER2) and its catalytically inactive homolog HER3 synergize to promote oncogenic signaling by the HER2/HER3 complex.
Natalia Jura +2 more
openaire +3 more sources
Characterisation of a pucBA deletion mutant from Rhodopseudomonas palustris lacking all but the pucBAd genes [PDF]
, 2017 Rhodopseudomonas palustris is a species of purple photosynthetic bacteria that has a multigene family of puc genes that encode the alpha and beta apoproteins, which form the LH2 complexes.
Carey, Anne-Marie +8 more
core +1 more source
Connexin Mutants and Cataracts [PDF]
Frontiers in Pharmacology, 2013 The lens is a multicellular, but avascular tissue that must stay transparent to allow normal transmission of light and focusing of it on the retina. Damage to lens cells and/or proteins can cause cataracts, opacities that disrupt these processes.
Viviana M. Berthoud +2 more
openaire +4 more sources
Mutant ADA2 in Vasculopathies [PDF]
New England Journal of Medicine, 2014 n engl j med 371;5 nejm.org july 31, 2014 478 CRT-D between patients with ischemic cardiomyopathy with NYHA class I or class II and patients with nonischemic cardiomyopathy. Hazard ratios were similar in these groups (0.66, 0.65, and 0.57, respectively), which denoted a similar effect size.
Van Eyck, Lien +2 more
openaire +10 more sources
Distinguishing Mutant knots [PDF]
Journal of Geometry and Physics, 2021 Knot theory is actively studied both by physicists and mathematicians as it provides a connecting centerpiece for many physical and mathematical theories. One of the challenging problems in knot theory is distinguishing mutant knots. Mutant knots are not distinguished by colored HOMFLY-PT polynomials for knots colored by either symmetric and or ...
L. Bishler +11 more
openaire +3 more sources
Phenotypic mixing and hiding may contribute to memory in viral quasispecies [PDF]
, 2003 Background. In a number of recent experiments with food-and-mouth disease virus, a deleterious mutant, was found to avoid extinction and remain in the population for long periods of time. This observation was called quasispecies memory.
Novella, Isabel S., Wilke, Claus O.
core +4 more sources