Mutant p53 as a guardian of the cancer cell
Cell Death and Differentiation, 2018 Forty years of research have established that the p53 tumor suppressor provides a major barrier to neoplastic transformation and tumor progression by its unique ability to act as an extremely sensitive collector of stress inputs, and to coordinate a ...
F. Mantovani, Licio Collavin, G. Del Sal
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The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic
Nature, 2020 Somatic mutations in p53, which inactivate the tumour-suppressor function of p53 and often confer oncogenic gain-of-function properties, are very common in cancer 1 , 2 .
E. Kadosh +13 more
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Journal of Social Intervention, 2016 Ed de Jonge. Beelden van de Professional. Inspiratiebronnen voor professionalisering. Delft: Eburon, 2015, 409 p., €35,00.
Fuusje de Graaff
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Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. [PDF]
, 2017 BackgroundPlasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth ...
Arinaitwe, Emmanuel +8 more
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Mutant Insulin Syndromes [PDF]
Hormone and Metabolic Research, 1988 Highly sensitive procedures for the characterization of molecular species of insulin in the circulation and for the isolation of the gene encoding human insulin have recently been developed. Nine subjects with abnormal forms of insulin or proinsulin have been reported.
A, Vinik, G, Bell
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Effect of Shipping on the Microbiome of Donor Mice Used to Reconstitute Germ-Free Recipients
Gut Microbes ReportsThe gut microbiome (GM) influences multiple processes during host development and maintenance. To study these events, fecal microbiota transfer (FMT) to germ-free (GF) recipients is often performed.
Zachary L. McAdams +7 more
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Evaluating Random Mutant Selection at Class-Level in Projects with Non-Adequate Test Suites
, 2016 Mutation testing is a standard technique to evaluate the quality of a test suite. Due to its computationally intensive nature, many approaches have been proposed to make this technique feasible in real case scenarios.
Demeyer, Serge +2 more
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Mutant phenotypes for thousands of bacterial genes of unknown function
Nature, 2018 One-third of all protein-coding genes from bacterial genomes cannot be annotated with a function. Here, to investigate the functions of these genes, we present genome-wide mutant fitness data from 32 diverse bacteria across dozens of growth conditions ...
M. Price +24 more
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Small molecule induced reactivation of mutant p53 in cancer cells [PDF]
, 2013 The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.
Adams +58 more
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Transient disappearance of RAS mutant clones in plasma: A counterintuitive clinical use of EGFR inhibitors in RAS mutant metastatic colorectal cancer [PDF]
, 2019 Genomic studies performed through liquid biopsies widely elucidated the evolutionary trajectory of RAS mutant clones under the selective pressure of EGFR inhibitors in patients with wild type RAS primary colorectal tumors. Similarly, the disappearance of
Belardinilli, Francesca +9 more
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