Results 21 to 30 of about 1,846,603 (258)

Evaluating the origin and spread of spotted lanternfly (Lycorma delicatula) in Japan

Population Ecology, EarlyView.
The invasive spotted lanternfly (Lycorma delicatula) is native to China and is a serious economic pest in the Republic of Korea and the United States, though it is not considered a pest in Japan. We established a distribution map of L. delicatula in Japan through a comprehensive review of published literature and citizen science reports and analyzed ...
Matthew T. Kamiyama, Michihiko Takahashi, Hannah J. Broadley, Francesc Gómez‐Marco, Mark S. Hoddle, Kenji Matsuura   +5 more
wiley   +1 more source

Fixation of a Deleterious Allele under Mutation Pressure and Finite Selection Intensity [PDF]

, 2011
The mean fixation time of a deleterious mutant allele is studied beyond the diffusion approximation. As in Kimura's classical work [M. Kimura, Proc. Natl. Acad. Sci. U.S.A.
Assaf, Assaf, Assaf, Assaf, Assaf, Blythe, Crow, Durrett, Dykman, Eriksson, Escudero, Etheridge, Ewens, Fisher, Fisher, Gardiner, Gillespie, Gillespie, Jukes, Kimura, Kimura, Kimura, Korolev, Kubo, Landau, Li, Mauro Mobilia, Michael Assaf, Mobilia, Moran, Moran, Muller, Nei, Risken, Sella, Slatkin, van Kampen, Wang, Whitlock, Wright, Zeng, Zeng   +41 more
core   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Killing Stubborn Mutants with Symbolic Execution [PDF]

arXiv, 2020
We introduce SeMu, a Dynamic Symbolic Execution technique that generates test inputs capable of killing stubborn mutants (killable mutants that remain undetected after a reasonable amount of testing). SeMu aims at mutant propagation (triggering erroneous states to the program output) by incrementally searching for divergent program behaviours between ...
arxiv  

Dynamic Mutant Subsumption Analysis using LittleDarwin [PDF]

Proceedings of the 8th ACM SIGSOFT International Workshop on Automated Software Testing. ACM, 2017, 2018
Many academic studies in the field of software testing rely on mutation testing to use as their comparison criteria. However, recent studies have shown that redundant mutants have a significant effect on the accuracy of their results. One solution to this problem is to use mutant subsumption to detect redundant mutants.
arxiv   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

In silico screening of 393 mutants facilitates enzyme engineering of amidase activity in CalB [PDF]

, 2012
Our previously presented method for high throughput computational screening of mutant activity (Hediger et al., arXiv:1203.2950) is benchmarked against experimentally measured amidase activity for 22 mutants of Candida antarctica lipase B (CalB). Using an appropriate cutoff criterion for the computed barriers, the qualitative activity of 15 out of 22 ...
arxiv   +1 more source

Drosophila melanogaster mutant tan [PDF]

, 2009
Drosophila melanogaster gene tan was originally discovered in the early 20th century as a mutant strain lacking the dark pi gment pattern of wild-type (wt) f lies and, therefore, showing a light yellowish brown color (McEwen, 1918 ...
Badaracco, Alejandra, Pérez, Martín Mariano, Quesada Allue, Luis Alberto   +2 more
core  

Mutant knots and intersection graphs [PDF]

, 2007
We prove that if a finite order knot invariant does not distinguish mutant knots, then the corresponding weight system depends on the intersection graph of a chord diagram rather than on the diagram itself.
Chmutov, Cunningham, J. Murakami, Kontsevich, Lando, Le, Sergei Chmutov, Sergei Lando, Vaintrob, Welsh   +9 more
core   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source