Results 51 to 60 of about 1,964,495 (300)

Effect size of delayed freezing, diurnal variation, and hindgut location on the mouse fecal microbiome

iScience
Summary: Practical considerations in fecal sample collection for microbiome research include time to sample storage, time of collection, and hindgut position during terminal collections.
Kevin L. Gustafson, Zachary L. McAdams, Amber L. Russell, Rebecca A. Dorfmeyer, Giedre M. Turner, Aaron C. Ericsson   +5 more
doaj   +1 more source

Source Code Optimization using Equivalent Mutants

, 2018
A mutant is a program obtained by syntactically modifying a program's source code; an equivalent mutant is a mutant, which is functionally equivalent to the original program. Mutants are primarily used in \emph{mutation testing}, and when deriving a test
Kushik, Natalia, López, Jorge, Yevtushenko, Nina   +2 more
core   +3 more sources

Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. [PDF]

, 2017
BackgroundPlasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth ...
Arinaitwe, Emmanuel, Conrad, Melissa, Dorsey, Grant, Greenhouse, Bryan, Kamya, Moses R, Nsobya, Samuel L, Rosenthal, Philip J, Tukwasibwe, Stephen, Tumwebaze, Patrick   +8 more
core   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Dominant effects of the immediate environment on the gut microbiome of mice used in biomedical research

mSystems
Studies using genetically engineered mouse (GEM) models are often performed over extended periods. The microbiomes of GEM colonies are expected to retain some of the microbial features present in the founder mice used to generate each GEM model and to ...
Aaron C. Ericsson, Zachary L. McAdams, Rebecca A. Dorfmeyer, Marcia L. Hart, Armedia O’Neill-Blair, James Amos-Landgraf, Craig L. Franklin   +6 more
doaj   +1 more source

Characterization of desnutrin functional domains: critical residues for triacylglycerol hydrolysis in cultured cells[S]

Journal of Lipid Research, 2010
Murine desnutrin/human ATGL is a triacylglycerol (TAG) hydrolase with a predicted catalytic dyad within an α-β hydrolase fold in the N-terminal region.
Robin E. Duncan, Yuhui Wang, Maryam Ahmadian, Jennifer Lu, Eszter Sarkadi-Nagy, Hei Sook Sul   +5 more
doaj   +1 more source

Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system [PDF]

, 1981
The cyclic AMP and cyclic GMP phosphodiesterase activities present in flies of six mutant strains of the dunce gene and in the parent wild- type strains are characterized. All of the mutants exhibit aberrant cyclic AMP metabolism.
Davis, Ronald L., Kiger, John A., Jr.
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension

Advanced Science
Refractory hypertension often involves centrally driven sympathetic augmentation. Yet effective central targets for the treatment of hypertension are still scarce.
Ying Shi, Yang‐Xun Zhang, Jun‐Yi Chen, Sai Ma, Wei‐Xuan Xue, Wei Li, Qian‐Xiao Li, Bo Song, Ya‐Ting Li, Hong‐Yu Ma, Shu‐Tao Xie, Hong‐Zhao Li, Di‐Jun Chen, Qi‐Peng Zhang, Hui‐Jie Ma, Jian‐Jun Wang, Lei Yu, Xiao‐Yang Zhang, Jing‐Ning Zhu   +18 more
doaj   +1 more source