Results 51 to 60 of about 1,574,250 (305)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Characterization of desnutrin functional domains: critical residues for triacylglycerol hydrolysis in cultured cells[S]

Journal of Lipid Research, 2010
Murine desnutrin/human ATGL is a triacylglycerol (TAG) hydrolase with a predicted catalytic dyad within an α-β hydrolase fold in the N-terminal region.
Robin E. Duncan, Yuhui Wang, Maryam Ahmadian, Jennifer Lu, Eszter Sarkadi-Nagy, Hei Sook Sul   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Effect size of delayed freezing, diurnal variation, and hindgut location on the mouse fecal microbiome

iScience
Summary: Practical considerations in fecal sample collection for microbiome research include time to sample storage, time of collection, and hindgut position during terminal collections.
Kevin L. Gustafson, Zachary L. McAdams, Amber L. Russell, Rebecca A. Dorfmeyer, Giedre M. Turner, Aaron C. Ericsson   +5 more
doaj   +1 more source

Generation and Characterization of a Foxtail Millet (Setaria italica) Mutant Library

Frontiers in Plant Science, 2019
Foxtail millet (Setaria italica) is attractive to plant scientists as a model plant because of several distinct characteristics, such as its short stature, rapid life cycle, sufficient seed production per plant, self-compatibility, true diploid nature ...
Jing Sun, Ngoc Sinh Luu, Zhenhua Chen, Bing Chen, Xuean Cui, Jinxia Wu, Zhiguo Zhang, Tiegang Lu   +7 more
doaj   +1 more source

Early stages of leaf development in has mutant of Arabidopsis thaliana

, 2011
The elucidation of molecular mechanisms underlying the leaf development can be facilitated by the detailed anatomical study of leaf development mutants.
Lj. Tubić, D. Stojičić, B. Uzelac, D. Janošević, S. Budimir   +4 more
core   +1 more source

Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse [PDF]

, 2012
Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Groh Janos, Dennis Klein, Spahn, Irene, Klein Dennis, Huber, M., Spahn, I., Ip, Chi Wang, Nave, Klaus-Armin, Diem Ricarda, Groh, J., Ip Chi Wang, Huber, Marianne, Sarah K. Williams, Rudolf Martini, Martini Rudolf, Kroner, A., Janos Groh, Ip, C., Williams, S., Edgar, Julia M., Kroner Antje, Huber Marianne, Ip, C.W., Martini, Rudolf, Nave Klaus-Armin, Martini, R., Antje Kroner, Chi Wang Ip, Diem, Ricarda, Edgar Julia M., Kroner, Antje, Julia M Edgar, Williams, Sarah K., Nave, K., Marianne Huber, Julia M. Edgar, Spahn Irene, Diem, R., Klaus-Armin Nave, Ricarda Diem, Sarah K Williams, Groh, Janos, Klein, Dennis, Klein, D., Edgar, J., Edgar, J.M., Williams Sarah K., Irene Spahn   +47 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Structure-Activity Relationship of Mutant KatG from INH resistant Mycobacterium tuberculosis [PDF]

, 2017
Mutation in katG gene of Mycobacterium tuberculosis encoding catalase-peroxidase that damage its enzyme activities is well associated with isoniazid (INH) resistance. The katG gene from INH resistant strain of M.
Purkan, Alfain Noerdin Alimny, Diah Amelia, Wiwin Retnowati, NIDN. 0009046803, Sri Puji Astuti Wahyuningsih, NIDN. 0021026604   +4 more
core   +1 more source

Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension

Advanced Science
Refractory hypertension often involves centrally driven sympathetic augmentation. Yet effective central targets for the treatment of hypertension are still scarce.
Ying Shi, Yang‐Xun Zhang, Jun‐Yi Chen, Sai Ma, Wei‐Xuan Xue, Wei Li, Qian‐Xiao Li, Bo Song, Ya‐Ting Li, Hong‐Yu Ma, Shu‐Tao Xie, Hong‐Zhao Li, Di‐Jun Chen, Qi‐Peng Zhang, Hui‐Jie Ma, Jian‐Jun Wang, Lei Yu, Xiao‐Yang Zhang, Jing‐Ning Zhu   +18 more
doaj   +1 more source