Results 71 to 80 of about 1,574,250 (305)

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science
B cells in the human immune system (HIS) mice exhibit weak responses to external antigens, characterized by insufficient antigen‐specific B cell proliferation, low antibody titers, and a lack of differentiation into effector B cell subsets.
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
doaj   +1 more source

Molecular and genetic dissection of peduncle elongation in rice [PDF]

Electronic Journal of Plant Breeding, 2011
Incomplete panicle exsertion in almost all the WA-based CMS lines is one of the major impediments in obtaining higher seedyield in hybrid rice breeding programs.
A. Subathra Devi , V.Krishnasamy, M.Raveendran, N.Senthil and S.Manonmani
doaj  

Turnip Mosaic Virus Coat Protein Deletion Mutants Allow Defining Dispensable Protein Domains for ‘in Planta’ eVLP Formation

Viruses, 2020
The involvement of different structural domains of the coat protein (CP) of turnip mosaic virus, a potyvirus, in establishing and/or maintaining particle assembly was analyzed through deletion mutants of the protein.
Carmen Yuste-Calvo, Pablo Ibort, Flora Sánchez, Fernando Ponz   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Unique Regulation of Sed-1 β-Lactamase in Citrobacter sedlakii: Insights on Resistance to Third-Generation Cephalosporin

Antibiotics
Background: The Citrobacter genus harbors class C (AmpC) and class A β-lactamases. Citrobacter freundii produces an inducible AmpC β-lactamase controlled by the LysR-type transcriptional regulator AmpR and cytosolic amidase AmpD.
Mako Watanabe, Ryuichi Nakano, Keizo Yamamoto, Akiyo Nakano, Yuki Suzuki, Kai Saito, Satoko Nakashima, Kentaro Endo, Kazuya Narita, Hisakazu Yano   +9 more
doaj   +1 more source

The improvement of early maturity red rice mutant trait for drought tolerance

International Journal of Plant Biology, 2017
Accession of red rice does not have the traits of early maturity, drought tolerance and high yield. Mutation is needed to obtain the desired genetic resources.
Eries D. Mustikarini, Noer Rahmi Ardiarini, Nur Basuki, Kuswanto Kuswanto   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

MYB and HD-ZIP IV homologs related to trichome formation are involved in epidermal bladder cell development in the halophyte Mesembryanthemum crystallinum L.

Plant Production Science, 2017
The common ice plant, Mesembryanthemum crystallinum L., a halophytic new functional leafy vegetable crop, develops epidermal bladder cells (EBCs) on the surfaces of its aerial organs.
Siranet Roeurn, Narihiro Hoshino, Ken-taro Soejima, Yuuka Inoue, John C. Cushman, Sakae Agarie   +5 more
doaj   +1 more source

Genetic Analysis and Fine Mapping of a Spontaneously Mutated Male Sterility Gene in Brassica rapa ssp. chinensis

G3: Genes, Genomes, Genetics, 2020
Male sterility has been widely used in hybrid seed production in Brassica, but not in B. rapa ssp. chinensis, and genetic models of male sterility for this subspecies are unclear. We discovered a spontaneous mutant in B. rapa ssp. chinensis.
Tzu-Kai Lin, Ya-Ping Lin, Shun-Fu Lin
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source