Results 61 to 70 of about 1,964,495 (300)

Immune modulation by sex hormones: unveiling the complex interplay and regulatory networks

open access: yesFrontiers in Immunology
Sex hormones, androgens, estrogens, and progestogens, play critical regulatory roles in the development and activation of the immune system, which contribute to the sex dimorphism in the disease susceptibility.
Bohan Wan   +4 more
doaj   +1 more source

Generation and Characterization of a Foxtail Millet (Setaria italica) Mutant Library

open access: yesFrontiers in Plant Science, 2019
Foxtail millet (Setaria italica) is attractive to plant scientists as a model plant because of several distinct characteristics, such as its short stature, rapid life cycle, sufficient seed production per plant, self-compatibility, true diploid nature ...
Jing Sun   +7 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study

open access: yesmSphere
BK polyomavirus (BKPyV) is a double-stranded DNA virus causing nephropathy, hemorrhagic cystitis, and urothelial cancer in transplant patients. The BKPyV-encoded capsid protein Vp1 and large T-antigen (LTag) are key targets of neutralizing antibodies and
Janani Durairaj   +9 more
doaj   +1 more source

Zebrafish retinal mutants

open access: yesVision Research, 1998
We have initiated a genetic analysis of the zebrafish visual system to identify novel molecules involved in vertebrate retinal function. Zebrafish are highly visual; they have four types of cones as well as rod photoreceptors, making it possible to study both rod and cone-mediated visual responses.
Brockerhoff, Susan E   +2 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Comprehensive mapping and modelling of the rice regulome landscape unveils the regulatory architecture underlying complex traits

open access: yesNature Communications
Unraveling the regulatory mechanisms that govern complex traits is pivotal for advancing crop improvement. Here we present a comprehensive regulome atlas for rice (Oryza sativa), charting the chromatin accessibility across 23 distinct tissues from three ...
Tao Zhu   +12 more
doaj   +1 more source

‘Miyagawa’ New Bud Mutant Type: Enhances Resistance to Low-Temperature Stress

open access: yesAgronomy
Global climate change is leading to more frequent extreme cold events, underscoring the need to study citrus cold tolerance to support breeding and enable potential northward expansion of citrus cultivation.
Shuangyou Wang   +7 more
doaj   +1 more source

The Mutagenesis of Lactobacillus Thermophilus for Enhanced L-(+)-Lactic Acid Accumulation Induced by Heavy Ion Irradiation

open access: yesBrazilian Archives of Biology and Technology, 2018
Screening promising L. thermophiles with high productivity, high efficiency and strong adaptability are very important in lactic acid industry. For this purpose, 80MeV/u carbon ions were applied to irradiate L. thermophiles.
Wei Hu   +6 more
doaj   +1 more source

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice [PDF]

open access: yes, 2006
Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell ...
Czech, Christian   +6 more
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