Results 81 to 90 of about 2,828,087 (336)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Molecular and genetic dissection of peduncle elongation in rice [PDF]

Electronic Journal of Plant Breeding, 2011
Incomplete panicle exsertion in almost all the WA-based CMS lines is one of the major impediments in obtaining higher seedyield in hybrid rice breeding programs.
A. Subathra Devi , V.Krishnasamy, M.Raveendran, N.Senthil and S.Manonmani
doaj  

Turnip Mosaic Virus Coat Protein Deletion Mutants Allow Defining Dispensable Protein Domains for ‘in Planta’ eVLP Formation

Viruses, 2020
The involvement of different structural domains of the coat protein (CP) of turnip mosaic virus, a potyvirus, in establishing and/or maintaining particle assembly was analyzed through deletion mutants of the protein.
Carmen Yuste-Calvo, Pablo Ibort, Flora Sánchez, Fernando Ponz   +3 more
doaj   +1 more source

Mutant loxP vectors for selectable marker recycle and conditional knock-outs [PDF]

, 2001
BACKGROUND: Gene disruption by targeted integration of transfected constructs becomes increasingly popular for studies of gene function. The chicken B cell line DT40 has been widely used as a model for gene knock-outs due to its high targeted integration
Arakawa, Hiroshi, Buerstedde, Jean-Marie, Lodygin, Dimitry   +2 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Unique Regulation of Sed-1 β-Lactamase in Citrobacter sedlakii: Insights on Resistance to Third-Generation Cephalosporin

Antibiotics
Background: The Citrobacter genus harbors class C (AmpC) and class A β-lactamases. Citrobacter freundii produces an inducible AmpC β-lactamase controlled by the LysR-type transcriptional regulator AmpR and cytosolic amidase AmpD.
Mako Watanabe, Ryuichi Nakano, Keizo Yamamoto, Akiyo Nakano, Yuki Suzuki, Kai Saito, Satoko Nakashima, Kentaro Endo, Kazuya Narita, Hisakazu Yano   +9 more
doaj   +1 more source

The improvement of early maturity red rice mutant trait for drought tolerance

International Journal of Plant Biology, 2017
Accession of red rice does not have the traits of early maturity, drought tolerance and high yield. Mutation is needed to obtain the desired genetic resources.
Eries D. Mustikarini, Noer Rahmi Ardiarini, Nur Basuki, Kuswanto Kuswanto   +3 more
doaj   +1 more source

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor.

Cancer Discovery, 2019
Allosteric kinase inhibitors offer a potentially complementary therapeutic strategy to ATP-competitive kinase inhibitors due to their distinct sites of target binding. In this study, we identify and study a mutant-selective EGFR allosteric inhibitor, JBJ-
Ciric To, Jaebong Jang, Ting Chen, Eunyoung Park, Mierzhati Mushajiang, Dries J. H. De Clercq, Man Xu, Stephen Wang, M. Cameron, D. Heppner, B. H. Shin, T. Gero, A. Yang, S. Dahlberg, Kwok-kin Wong, M. Eck, N. Gray, P. Jänne   +17 more
semanticscholar   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

MYB and HD-ZIP IV homologs related to trichome formation are involved in epidermal bladder cell development in the halophyte Mesembryanthemum crystallinum L.

Plant Production Science, 2017
The common ice plant, Mesembryanthemum crystallinum L., a halophytic new functional leafy vegetable crop, develops epidermal bladder cells (EBCs) on the surfaces of its aerial organs.
Siranet Roeurn, Narihiro Hoshino, Ken-taro Soejima, Yuuka Inoue, John C. Cushman, Sakae Agarie   +5 more
doaj   +1 more source