Results 261 to 270 of about 1,763,257 (296)
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Microsatellite instability: The mutator that mutates the other mutator
Nature Medicine, 1996Microsatellite mutations are useful markers of both tumor clonality and genomic instability but the origin of the mutator mutations responsible is still not well understood (pages 676–681).
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Science, 2003
Among a few human genes, there has long been evidence for a significant difference in specific mutations between males and females and an increase in mutation with paternal age. The gene for fibroblast growth factor receptor 2, FGFR2 , encodes a receptor tyrosine kinase protein, and mutation of nucleotide 755 of ...
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Among a few human genes, there has long been evidence for a significant difference in specific mutations between males and females and an increase in mutation with paternal age. The gene for fibroblast growth factor receptor 2, FGFR2 , encodes a receptor tyrosine kinase protein, and mutation of nucleotide 755 of ...
+4 more sources
Software Testing, Verification and Reliability, 2001
AbstractApplications that utilize a broker‐based architecture are often composed of components that need to be tested individually and in combination. Furthermore, adequacy assessment of tests of components is useful in that it assists testers in identifying weaknesses in the tests generated so far and in offering hints on what the new tests must be ...
S. Ghosh, A. P. Mathur
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AbstractApplications that utilize a broker‐based architecture are often composed of components that need to be tested individually and in combination. Furthermore, adequacy assessment of tests of components is useful in that it assists testers in identifying weaknesses in the tests generated so far and in offering hints on what the new tests must be ...
S. Ghosh, A. P. Mathur
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International Journal of Computer Mathematics, 2011
We propose mutation systems as a model of the evolution of a string subject to the effects of mutations and a fitness function. One fundamental question about such a system is whether knowing the rules for mutations and fitness, we can predict whether it is possible for one string to evolve into another.
Dana Angluin +2 more
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We propose mutation systems as a model of the evolution of a string subject to the effects of mutations and a fitness function. One fundamental question about such a system is whether knowing the rules for mutations and fitness, we can predict whether it is possible for one string to evolve into another.
Dana Angluin +2 more
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Nature, 1991
The detection and characterization of mutations in genes has become a major area of interest in many areas of biology. Such variation may account for speciation, tumour formation, drug resistance, as well as the more obvious nature of inherited disease.
R G, Cotton, A D, Malcolm
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The detection and characterization of mutations in genes has become a major area of interest in many areas of biology. Such variation may account for speciation, tumour formation, drug resistance, as well as the more obvious nature of inherited disease.
R G, Cotton, A D, Malcolm
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The Indian Journal of Pediatrics, 2008
To uncover the frequency and the spectrum of NPHS2 mutations in Egyptian children with non familial steroid-resistant nephrotic syndrome (SRNS).Sixteen patients were screened by PCR-single-strand conformation polymorphism analysis of NPHS2 gene followed by direct sequencing.NPHS2 mutations were evident in four patients (25%) who were bearing four novel
Ashraf, Bakr +7 more
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To uncover the frequency and the spectrum of NPHS2 mutations in Egyptian children with non familial steroid-resistant nephrotic syndrome (SRNS).Sixteen patients were screened by PCR-single-strand conformation polymorphism analysis of NPHS2 gene followed by direct sequencing.NPHS2 mutations were evident in four patients (25%) who were bearing four novel
Ashraf, Bakr +7 more
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Mutational analysis: new mutations
1995Abstract In the last few years the search for mutations and sequence polymorphisms has been dramatically accelerated by the use of PCR and subsequently by direct sequencing of PCR products (1, 2). In spite of these powerful new methods, direct sequencing is not always practicable in detecting mutations because they may be positioned ...
K Michaelides +4 more
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Journal of Theoretical Biology, 2003
A traditional picture of evolutionary dynamics with constant fitness is that of genomes living in sequence space and adapting on fitness landscapes. Mutation rates are considered to be constant or externally regulated. If, however, we take into account that genomes also encode for enzymes that perform replication and error correction, then individual ...
Sasaki, Akira, Nowak, Martin A.
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A traditional picture of evolutionary dynamics with constant fitness is that of genomes living in sequence space and adapting on fitness landscapes. Mutation rates are considered to be constant or externally regulated. If, however, we take into account that genomes also encode for enzymes that perform replication and error correction, then individual ...
Sasaki, Akira, Nowak, Martin A.
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Trends in Plant Science, 2002
Mutator (Mu) element insertion has become the main way of mutating and cloning maize genes, but we are only beginning to understand how this transposon system is regulated. Mu elements are under tight developmental control and are subject to a form of epigenetic regulation that shares some features with the regulation of paramutable maize genes.
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Mutator (Mu) element insertion has become the main way of mutating and cloning maize genes, but we are only beginning to understand how this transposon system is regulated. Mu elements are under tight developmental control and are subject to a form of epigenetic regulation that shares some features with the regulation of paramutable maize genes.
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Dermatologic Clinics, 2010
A mutation is an event that produces heritable changes in the DNA. There are many different types of mutations, including point mutations (changes that imply loss, duplication, or alterations of small DNA segments, often involving a single or a few nucleotides) and major DNA changes (loss, duplication, or rearrangements of entire genes or of gene ...
Daniele, Castiglia, Giovanna, Zambruno
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A mutation is an event that produces heritable changes in the DNA. There are many different types of mutations, including point mutations (changes that imply loss, duplication, or alterations of small DNA segments, often involving a single or a few nucleotides) and major DNA changes (loss, duplication, or rearrangements of entire genes or of gene ...
Daniele, Castiglia, Giovanna, Zambruno
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