Results 31 to 40 of about 4,355,944 (375)
Nature Communications, 2018 This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee +11 more
doaj +1 more source
Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]
, 2015 Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A. +5 more
core +1 more source
Molecular Cancer, 2022 Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development.
Claudia Buhigas +26 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2023 Gene therapy strategies that effectively inhibit HIV-1 replication are needed to reduce the requirement for lifelong antiviral therapy and potentially achieve a functional cure.
Krista A. Delviks-Frankenberry +5 more
doaj +1 more source
Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation [PDF]
, 2016 Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in the
A Pijpe +67 more
core +4 more sources
Current Protocols in Human Genetics, 2003 AbstractAs part of the Human Genome Variation Society (formerly known as the HUGO Mutation Database Initiative), a committee was formed to suggest standards for the description of sequence variants in DNA, RNA, and protein sequences. The committee proposed that the nomenclature should be unequivocal, precise, and short, and should prevent any possible ...
den Dunnen, J. T. +1 more
openaire +3 more sources
Nonlinear Dynamics of the Rock-Paper-Scissors Game with Mutations
, 2015 We analyze the replicator-mutator equations for the Rock-Paper-Scissors game. Various graph-theoretic patterns of mutation are considered, ranging from a single unidirectional mutation pathway between two of the species, to global bidirectional mutation ...
Strogatz, Steven H. +1 more
core +1 more source
Mutations and amplification of oncogenes in endometrial cancer [PDF]
, 1999 Alterations in oncogenes are critical steps in the development of endometrial cancer. To investigate the potential clinical relevance of the amplification of the oncogenes c-erbB2, c-myc, and int-2 and the mutation of K-ras in endometrial cancer, 112 ...
An, Han-Xiang +5 more
core +1 more source
ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability
Nature Communications, 2017 MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee +11 more
doaj +1 more source
Echec des élites et régressions économiques de Madagascar [PDF]
Mouvements et Enjeux Sociaux, 2022 Madagascar est le seul pays dans le monde où le PIB par tête n’a cessé de régresser depuis l’indépendance. Une situation qui est à la fois préoccupante et étonnante pour les chercheurs, observateurs et experts de différentes disciplines.
Jean Angelson RANDRIAMBOAVONJY
doaj