Results 31 to 40 of about 3,006,553 (325)
Mutation Spectra and the Neutrality of Mutations [PDF]
Australian Journal of Biological Sciences, 1974 The effect of amino acid replacements on enzyme function was studied in the tJ-galactosidase of Escherichia coli. Mutants possessing 50% or less of normal enzyme activity were isolated and examined. Of 733 amino acid substitutions calculated to have occurred, only 11 reduced tJ-galactosidase activity below 50 %.
openaire +3 more sources
Molecular Cancer, 2022 Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development.
Claudia Buhigas +26 more
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The Genetic Basis of Mutation Rate Variation in Yeast. [PDF]
, 2018 Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis ...
Bloom, Joshua S +2 more
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ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability
Nature Communications, 2017 MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee +11 more
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Silting mutation in triangulated categories
, 2011 In representation theory of algebras the notion of `mutation' often plays important roles, and two cases are well known, i.e. `cluster tilting mutation' and `exceptional mutation'.
Aihara, Takuma, Iyama, Osamu
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Echec des élites et régressions économiques de Madagascar [PDF]
Mouvements et Enjeux Sociaux, 2022 Madagascar est le seul pays dans le monde où le PIB par tête n’a cessé de régresser depuis l’indépendance. Une situation qui est à la fois préoccupante et étonnante pour les chercheurs, observateurs et experts de différentes disciplines.
Jean Angelson RANDRIAMBOAVONJY
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RAS mutation status predicts survival and patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases. [PDF]
, 2013 ObjectiveTo determine the impact of RAS mutation status on survival and patterns of recurrence in patients undergoing curative resection of colorectal liver metastases (CLM) after preoperative modern chemotherapy.BackgroundRAS mutation has been reported ...
Aloia, Thomas A +8 more
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Fushe yanjiu yu fushe gongyi xuebaoTo improve the rate of pesticide utilization, reduce pesticide usage, and effectively eliminate the adverse effects of pesticides on the environment, a carrier material was prepared by modifying starch using a one-step irradiation treatment. This carrier
LIU Lu +7 more
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A practical guide for mutational signature analysis in hematological malignancies
Nature Communications, 2019 Mutational signature analysis provides important information about the mutational processes underpinning different stages of tumorigenesis. Here, the authors compare publicly available signature extraction tools and suggest a framework for the generation
Francesco Maura +14 more
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Abstention électorale à Madagascar : entre déficit civique et défaillance de la classe politique [PDF]
Mouvements et Enjeux Sociaux, 2022 Longtemps ignorée par les chercheurs en sciences sociales, l’abstention électorale devient une des problématiques majeures de la démocratie représentative en ce moment. Tel est également le cas pour Madagascar.
Jean Angelson RANDRIAMBOAVONJY
doaj