Results 61 to 70 of about 4,183,748 (324)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Concordance and Mutation

, 2001
We provide a framework for studying the interplay between concordance and positive mutation and identify some of the basic structures relating the two. The fundamental result in understanding knot concordance is the structure theorem proved by Levine ...
Atiyah, Bredon, Burde, Casson, Casson, Charles Livingston, Cochran, Conner, Donaldson, Fox, Fox, Freedman, Freedman, Gilmer, Gilmer, Herald, Kervaire, Kirby, Kirby, Kirby, Litherland, Litherland, Livingston, Livingston, Livingston, Meyerhoff, Morton, Naik, Paul A Kirk, Porti, Rolfsen, Serre, Tristram, Walker, Witten   +34 more
core   +1 more source

DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer [PDF]

, 2019
DNA-dependent protein kinase (DNA-PK), a member of phosphatidylinositol-kinase family, is a key protein in mammalian DNA double-strand break (DSB) repair that helps to maintain genomic integrity.
Ansari, Shabbir Ahmed, Chelakkot, Ayshwarya Lakshmi, Chelakkot, Chaithanya, Chelakkot, Vipin Shankar, Dellaire, Graham, El-Awady, Raafat, Ethiraj, Kannatt Radhakrishnan, George, Vazhappilly Cijo, Mantso, Theodora, Menon, Varsha, Mitsiogianni, Melina, Panagiotidis, Mihalis, Ramadan, Wafaa, Vasantha Rupasinghe, H.P.   +13 more
core   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Choosing Mutation and Crossover Ratios for Genetic Algorithms - A Review with a New Dynamic Approach

Inf., 2019
Genetic algorithm (GA) is an artificial intelligence search method that uses the process of evolution and natural selection theory and is under the umbrella of evolutionary computing algorithm.
Ahmad Hassanat, Khalid Almohammadi, Esra’a Alkafaween, Eman Abunawas, A. Hammouri, V. B. Surya Prasath   +5 more
semanticscholar   +1 more source

Adaptations Accumulated under Prolonged Resource Exhaustion Are Highly Transient

mSphere, 2020
Many nonsporulating bacterial species can survive for years within exhausted growth media in a state termed long-term stationary phase (LTSP). We have been carrying out evolutionary experiments aimed at elucidating the dynamics of genetic adaptation ...
Sarit Avrani, Sophia Katz, Ruth Hershberg   +2 more
doaj   +3 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Repeatability of evolution on epistatic landscapes

, 2015
Evolution is a dynamic process. The two classical forces of evolution are mutation and selection. Assuming small mutation rates, evolution can be predicted based solely on the fitness differences between phenotypes.
Bauer, Benedikt, Gokhale, Chaitanya S.
core   +1 more source

Mutational signatures are jointly shaped by DNA damage and repair

Nature Communications, 2020
Recent research has shown that mutational signatures reflective of the history of a cancer can be detected in a cancer genome. Here, using whole genome sequencing of DNA repair deficient and proficient nematodes exposed to genotoxins, the authors show ...
Nadezda V. Volkova, Bettina Meier, Víctor González-Huici, Simone Bertolini, Santiago Gonzalez, Harald Vöhringer, Federico Abascal, Iñigo Martincorena, Peter J. Campbell, Anton Gartner, Moritz Gerstung   +10 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source