Results 191 to 200 of about 199,597 (317)

Beyond tumor mutation burden: tumor neoantigen burden as a superior prognostic biomarker in resected gastric cancer. [PDF]

Front Immunol
Lu T, Cao J, Liu P, Pan X, Shen Y, Wang J, Chen Z, Liu Y, Zhang F, Zhang H, Zhang G, Wang Y, Wan J, Xi H.   +13 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Nivolumab–ipilimumab — exploiting the mutation burden of NSCLCs [PDF]

Nature Reviews Clinical Oncology, 2018
openaire   +2 more sources

Supplementary Figure S1 from Association of Tumor Mutational Burden and PD-L1 with the Efficacy of Pembrolizumab with or without Chemotherapy versus Chemotherapy in Advanced Urothelial Carcinoma [PDF]

Aude Fléchon, Rafael Morales‐Barrera, Thomas Powles, Ajjai Alva, Mustafa Özgüroğlu, Tibor Csőszi, Yohann Loriot, Alejo Rodríguez‐Vida, Lajos Géczi, Susanna Y. Cheng, Yves Fradet, Stéphane Oudard, Christof Vulsteke, Şeyda Gündüz, Ronac Mamtani, Evan Y. Yu, Á. Montesa Pino, Urbano Anido, Mehmet Alı Nahıt Şendur, Gwénaëlle Gravis, János Révész, Vladimir Kostorov, Olivier Huillard, Junshui Ma, Mohini Rajasagi, Amir Vajdi, Jared Lunceford, Răzvan Cristescu, Kentaro Imai, Blanca Homet Moreno, Nobuaki Matsubara   +30 more
openalex   +1 more source

High tumor mutation burden (TMB) in microsatellite stable (MSS) colorectal cancers: Diverse molecular associations point to variable pathophysiology

, 2023
Ioannis A. Voutsadakis
openalex   +1 more source

iRUNNER: A Baseline Mutation Burden Regression for Identifying Gene Interaction Between Rare Variants for Diseases. [PDF]

Genomics Proteomics Bioinformatics
Jiang 江慧 H, Tang 唐斌 B, Li 李堃 K, Zhang 张柳彬 L, Liang 梁俊豪 J, Tang CS, Tang CS, Tam PK, Wang B, Song 宋又强 Y, Wang 王强 Q, Li 李俊 MJ, Huang 黄海亮 H, Li 李淼新 M.   +13 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Sex differences in gastric cancer mutational burden reflect MLH1-associated epigenetic regulation

Noa Klein, Dorit Shweiki
openalex   +1 more source

Systematic literature review on the prevalence and burden of estrogen receptor 1 (ESR1) gene mutations in advanced breast cancer [PDF]

Kimberly Ruiz, Stella Stergiopoulos, Chloe Grace Rose   +2 more
openalex   +1 more source

Impact of tumor mutation burden on the prognosis of patients with unresectable hepatocellular carcinoma undergoing transcatheter arterial chemoembolization combined with immunotherapy and anti-angiogenic drugs. [PDF]

J Gastrointest Oncol
Huang XW, Wang DJ, Cai BZ.
europepmc   +1 more source