Results 201 to 210 of about 199,597 (317)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Clinical Manifestations of VEXAS Syndrome Across a Broad Spectrum of UBA1 Mutation Burden. [PDF]

Arthritis Rheumatol
Anderson M, Ercelen D, Richardson A, Kim J, Torene RI, Sirenko M, Haley JS, Cook A, Hill W, Dove J, Retterer K, Carroll E, Carey DJ, Asgari S, Stewart DR, Beck DB.   +15 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Tumors with mutations in chromatin regulators are associated with higher mutational burden and improved response to checkpoint immunotherapy

Marija Gjorgjievska, Djansel Bukovec, Sanja Mehandziska, Milan Risteski, Ivan Kungulovski, Zan Mitrev, Goran Kungulovski   +6 more
openalex   +1 more source

Systemic inflammation biomarkers can identify high tumor mutation burden in lung adenocarcinoma. [PDF]

BMC Cancer
Fang J, Li Q, Xu N, Yang X, Zhang Q, Chen Y, Li H.   +6 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours [PDF]

, 2011
Simone Weidlich, Katherine Walsh, D. Crowther, Michael E. Burczynski, G Feuerstein, F. A. CAREY, R. Steele, C. Roland Wolf, Gino Miele, Gillian Smith   +9 more
openalex   +1 more source

The prognostic impact of myeloid co-mutation burden in TP53-mutated AML/MDS after allogeneic stem cell transplantation: a multicenter retrospective analysis. [PDF]

Ann Hematol
Sun Y, Qin S, Wang L, Yi H, Ding L, Cai B, Liu N, Li Y, Hu J, Qiao Z, Li F, Liu D, Dou L, Hu L.   +13 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Conjunctival melanoma genomic analysis reveals intermediate tumor mutation burden and genomic overlap with cutaneous melanoma. [PDF]

NPJ Precis Oncol
Dimitriou F, Wu X, Nagarajan P, Glitza IC, Zhao L, Ning J, Patel SP, Wargo JA, Futreal A, Woodman S, McQuade JL, Esmaeli B.   +11 more
europepmc   +1 more source