Results 211 to 220 of about 199,597 (317)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Figure S1 from Characterization of Non-Monotonic Relationships between Tumor Mutational Burden and Clinical Outcomes [PDF]

Jordan Anaya, Julia Kung, Alexander S. Baras   +2 more
openalex   +1 more source

Tumour mutation burden drives survival outcomes in pancreatic ductal adenocarcinoma and enables noninvasive prediction via dual-layer spectral CT. [PDF]

Insights Imaging
Liu J, Shi S, Chen M, Luo J, Wei L, Chen M, Shi Z, Wang L, Luo Y, Feng ST.   +9 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Differences in tumor mutational burden assessment: a national ring trial [PDF]

Acta Oncologica
Christine Federspiel Secher, Christina Westmose Yde, Britt Elmedal Laursen, Estrid l Høgdall, Henriette Sylvain Thomsen, Tim Svenstrup Poulsen, Mads Sønderkær, Tina Kringelbach, Mads Malik Aagaard Jørgensen, Rikke Frydendahl Sick Olsen, Anja Elaine Sørensen, null Christian Baudet, null Magnús Halldór Gíslason, null Michael Knudsen, null Ida Kappel Buhl   +14 more
openaire   +3 more sources

Replication-associated mechanisms contribute to an increased CpG > TpG mutation burden in mismatch repair-deficient cancers. [PDF]

Genome Med
Ward JC, Soriano I, Thorn S, Fernández-Tajes J, Sherwood K, Gül G, Scheffers J, Frangou A, Kinnersley B, Kafetzopoulos I, Sproul D, Galavotti S, Palles C, Gruber AJ, Church DN, Tomlinson I.   +15 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Case Report: Mixed ductal-lobular carcinoma consisting of invasive lobular carcinoma with a glycogen-rich clear cell pattern and elevated tumor mutation burden. [PDF]

Front Oncol
Kawachi K, Tang X, Kasajima R, Katayama K, Yamaguchi R, Yamaguchi K, Furukawa Y, Imoto S, Miyano S, Yoshioka E, Washimi K, Okubo Y, Sato S, Yokose T, Miyagi Y.   +14 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Skin mutation burden drives adaptive immunity and response to immunotherapy. [PDF]

J Immunother Cancer
Looney T.
europepmc   +1 more source