Results 221 to 230 of about 199,597 (317)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

PC06.03 Tumor Mutation Burden - PRO [PDF]

Journal of Thoracic Oncology, 2018
openaire   +1 more source

Optimizing immunotherapy for lung cancer: integrating genetic alterations and the tumor mutational burden to refine patient selection

Takahiro Sugawara, Taiki Hakozaki, Masahiro Seike, Yukio Hosomi   +3 more
openalex   +1 more source

Novel CYP2A7/CYP2A6 germline hybrids associated with mutation burden in lung cancer revealed by whole-genome long-read sequencing. [PDF]

Sci Rep
Ohnami S, Hatakeyama K, Nagashima T, Maruyama K, Isaka M, Kamada F, Nakatani S, Shimoda Y, Mizuguchi M, Naruoka A, Miyake K, Ohshima K, Ohnami S, Akiyama Y, Urakami K, Yamaguchi K.   +15 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Clinical outcomes of tumor-agnostic targeting of BRAF, tumor mutation burden-high, and RET. [PDF]

ESMO Open
Ronaghy A, Crimini E, Holla VR, Mills Shaw KR, Doefler AM, Campbell E, Yang RK, Iorgulescu JB, Patel KP, McPherson DD, Ning J, Meric-Bernstam F, Karp DD.   +12 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells. [PDF]

Cancer Discov
Struys I, Velázquez C, Ubels J, LeJeune CL, van Roosmalen MJ, Rosendahl Huber AKM, van Leeuwen AJCN, Bossuyt W, Thienpont B, Voet T, Van Calsteren K, Lenaerts L, van Boxtel R, Amant F.   +13 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

TMBquant: an explainable AI-powered caller advancing tumor mutation burden quantification across heterogeneous samples. [PDF]

Brief Bioinform
Wang S, Wang X, Zhu X, Wang X, Liu Y, Zhao M, Chang Z, Shao Y, Zhang H, Yang S, Wang J.   +10 more
europepmc   +1 more source