Results 81 to 90 of about 9,839 (200)
Probing the Cancer Mutational Landscape of KMT2 Regulatory Subunits
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.Pipeline to characterize the KMT2 cancer mutational landscape starts with querying genomic databases (top left) for mutations mapping to ASH2L, RbBP5, WDR5, and DPY‐30. Subsequent steps include the expression of these mutants in cell (bottom left), their systemic purification and biochemical characterization using isothermal titration calorimetry ...
Sabrina Grégoire +9 more
wiley +1 more source
ChemistrySelect, Volume 11, Issue 14, 13 April 2026.ABSTRACT Antimicrobial resistance (AMR) has emerged as one of the most critical global health challenges, undermining the clinical efficacy of existing antibiotics and threatening modern therapeutic strategies. The ongoing misuse and overuse of antimicrobial agents have accelerated the evolution of resistant bacterial strains and parasites ...
Subham Kumar Vishwakarma +2 more
wiley +1 more source
Phenotypic presentation of the Ser63Del MPZ mutation [PDF]
Journal of the Peripheral Nervous System, 2012 Mutations in MPZ cause CMT1B, the second most frequent cause of CMT1. Elegant studies with Ser63del mice suggest that Ser63del MPZ is retained in the ER where it activates the unfolded protein response (UPR) that contributes to the neuropathy. Clinical information about patients with this mutation is limited.
Lindsey J, Miller +3 more
openaire +2 more sources
Colorectal cancer carcinogenesis: a review of mechanisms
Cancer Biology & Medicine, 2016 Colorectal cancer (CRC) is the second most common cancer in women and the third most common in men globally. CRC arises from one or a combination of chromosomal instability, CpG island methylator phenotype, and microsatellite instability.
Kanwal Tariq, Kulsoom Ghias
doaj +1 more source
Transposable elements: Functional aspects and applications as drivers of crop innovation
Crop Science, Volume 66, Issue 2, March/April 2026.Abstract Transposable elements (TEs), which were once relegated to the status of genomic parasites, are today accepted as important agents of plant genome evolution and adaptation. This review integrates evidence pointing to their dual function as drivers of genetic diversity and instability, with a focus on their contribution to phenotypic innovation,
Flávia Layse Belém Medeiros +12 more
wiley +1 more source
The Plant Genome, Volume 19, Issue 1, March 2026.Abstract Phytophthora crown rot, caused by Phytophthora cactorum, is a soilborne disease with broad impacts on cultivated strawberry (Fragaria × ananassa). A resistance locus, RPc2, was previously identified in octoploid strawberries, but the underlying genomic architecture and causal genes remained uncharacterized.
Hyeondae Han +14 more
wiley +1 more source
Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon
BMC Biology, 2023 Background Despite the process of DNA replication being mechanistically highly conserved, the location of origins of replication (ORI) may vary from one tissue to the next, or between rounds of replication in eukaryotes, suggesting flexibility in the ...
Roman Jaksik +2 more
doaj +1 more source
The Plant Genome, Volume 19, Issue 1, March 2026.Abstract Meiotic recombination is essential for generating genetic diversity, driving plant evolution, and enabling crop improvement, yet its uneven distribution across genomes constrains breeding efforts. Here, we investigated the multi‐omic landmarks that shape the recombination landscape in Brassica napus by integrating epigenomic, genomic, and ...
Jose A. Montero‐Tena +6 more
wiley +1 more source
Study of the mutator phenotype frequency to beta-lactam resistance in pathogenic E. coli strains.
, 2013 Atualmente a alta incidência de isolados multirresistentes a antibióticos utilizados na clinica tem-se tornado alarmante. Estudos recentes demonstraram que um dos motivos que contribuem para o aumento da resistência a antibióticos em bactérias é a ...
Costa, Débora dos Santos +1 more
core +1 more source
Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features [PDF]
, 2004 Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly ...
Gross, M. +9 more
core +1 more source