Results 101 to 110 of about 9,839 (200)

Differential effect of ultraviolet light on the induction of simian virus 40 and a cellular mutator phenotype in transformed mammalian cells

, 1985
UV irradiation of simian virus 40 (SV40)-transformed human and hamster cells induced them both to express a mutator phenotype and to produce SV40. The mutator could also be activated indirectly by transfecting unirradiated cells with UV-damaged calf ...
van der Lubbe, Jos, Dinsart, Christiane, Cornelis, Jan, Rommelaere, Jean, Decaesstecker, Mireille, Van Der Eb, Alex A.J.   +5 more
core   +1 more source

Effect of Denervation on Skeletal Muscle Mitochondria in Heterozygous mtDNA Mutator Mice

FASEB BioAdvances, Volume 8, Issue 2, February 2026.
Denervation induces mitochondrial dysfunction and oxidative stress in skeletal muscle. In PolG(+/mut) mice, denervation led to reduced mitochondrial DNA copy number and a pronounced upregulation of the antioxidant enzyme catalase, despite comparable levels of muscle atrophy, mitochondrial content, and mitochondrial dynamics‐related proteins compared to
Takanaga Shirai, Hideto Hanakita, Kohei Takeda, Yu Kitaoka, Kaori Ishikawa, Kazuto Nakada, Tohru Takemasa   +6 more
wiley   +1 more source

Role of mutation in pseudomonas aeruginosa biofilm development.

, 2009
The survival of bacteria in nature is greatly enhanced by their ability to grow within surface-associated communities called biofilms. Commonly, biofilms generate proliferations of bacterial cells, called microcolonies, which are highly recalcitrant, 3 ...
Collins, Samuel L., Webb, Jeremy S., Conibear Tim C. R., Collins Samuel L., Conibear, Tim C. R., Jeremy S. Webb, Webb Jeremy S., Samuel L. Collins, Samuel L Collins, Tim C R Conibear, Jeremy S Webb, Tim C. R. Conibear   +11 more
core   +1 more source

THE MUTATOR PHENOTYPE IS A FEATURE OF IMMUNODEFICIENCY-RELATED LYMPHOMAS

, 2004
The mutator phenotype caused by defects in the mismatch repair system is observed in a subset of solid neoplasms characterized by widespread microsatellite instability-high (MSI-H).
CHARLOTTE F, MARTIN A, LEBLON V, CORNILLET LEFEVRE P, BARDESSOULE D, DELFAU MH, ADOTTI F, FERLICOT S, FAUILLARD J, GAULARD P, DAVI F, RAPHAEL M, HAMELIN R., CAPELLO, Daniela, POIREL H, GAIDANO, Gianluca, BERGER F, BRENNETOT C, GABARRE J, GUETTIER C, ECLACHE V, KRIMI A, PREVOT S, BUHARD O, CANIONI D, DUVAL A, AUBRY A   +26 more
core  

A mutant Hpall methyltransferase functions as a mutator enzyme

, 1995
DNA (cytoslne-5)-methyttransferases can cause deamination of cytosine when the cofactor S-adenosylmethionine (AdoMet) Is limiting and thus function as sequence-specific C→U mutator enzymes.
Shen, Jiang-Cheng, Jones, Peter A., Schmutte, Christoph, Yang, Allen S., Zingg, Jean-Marc   +4 more
core   +1 more source

In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice [PDF]

, 2014
In mtDNA mutator mice, mtDNA mutations accumulate leading to a rapidly aging phenotype. However, there is little evidence of oxidative damage to tissues, and when analyzed ex vivo, no change in production of the reactive oxygen species (ROS) superoxide ...
Prime, Tracy A., Hartley, Richard C., Shabalina, Irina G.,, Budd, Ralph C., Logan, Angela, Shabalina, Irina G., Kalinovich, Anastasia V., Rogatti, Sebastian, Murphy, Michael P., Cannon, Barbara,, Kalinovich, Anastasia V.,, Cannon, Barbara   +11 more
core   +1 more source

Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers. [PDF]

Proc Natl Acad Sci U S A, 2022
Boot A, Liu M, Stantial N, Shah V, Yu W, Nitiss KC, Nitiss JL, Jinks-Robertson S, Rozen SG.   +8 more
europepmc   +1 more source

The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins

BMC Cell Biology, 2007
Background The NCOA7 gene product is an estrogen receptor associated protein that is highly similar to the human OXR1 gene product, which functions in oxidation resistance. OXR genes are conserved among all sequenced eukaryotes from yeast to humans.
Shao Wenlin, Elliott Nathan A, Farrell Timothy, Kolpak Adrianne, Durand Mathieu, Brown Myles, Volkert Michael R   +6 more
doaj   +1 more source

A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas

, 2011
Oncogene-induced DNA replication stress is thought to drive genomic instability in cancer. In particular, replication stress can explain the high prevalence of focal genomic deletions mapping within very large genes in human tumors.
Nikolaev, S.I., Sotiriou, S.K., Sougioultzis, S., Guipponi, M., Saarela, J., Antonarakis, S.E., Edgren, H., Pateras, I.S., Halazonetis, T.D., Robyr, D., Santoni, F., Almusa, H., Gorgoulis, V.G.   +12 more
core  

The mutator pathway is a feature of immunodeficiency-related lymphomas.

, 2004
The mutator phenotype caused by defects in the mismatch repair system is observed in a subset of solid neoplasms characterized by widespread microsatellite instability-high (MSI-H).
Charlotte, Frederic, Duval, Alex, Ferlicot, Sophie, Eclache, Virginie, Gaidano, Gianluca, Martin, Antoine, Prevot, Sophie, Krimi, Amor, Cornillet Lefevre, Pascale, Berger, Francoise, Capello, Daniela, Davi, Frederic, Gaulard, Philippe, Leblond, Veronique, Gabarre, Jean, Aubry, Alban, Raphael, Martine, Buhard, Olivier, Feuillard, Jean, Adotti, Francoise, Bordessoule, Dominique, Canioni, Danielle, Guettier, Catherine, Helene Delfau, Marie, Hamelin, Richard, Poirel, Helene, Brennetot, Caroline   +26 more
core   +1 more source