Results 111 to 120 of about 9,839 (200)

Molecular mechanisms underlying the rate of progeria onset in mtDNA mutator mouse strains [PDF]

, 2020
The mtDNA mutator mouse model contains a D257A mutation in the exonuclease domain of the POLG gene, which generates a mouse with an increased number of mtDNA mutations. The mouse shows several characteristics of premature ageing.
Albarran Gutierrez, Sara Ruth
core  

KRAS G12C mutation in NSCLC in a small genetic center: insights into sotorasib therapy response potential

Scientific Reports
Lung cancer remains a significant health challenge, characterized by aberrant tissue growth within the pulmonary system. Early carcinogenic events often involve genomic instability and the emergence of a mutator phenotype.
Metin Eser, Gulam Hekimoglu, Murat Hakki Yarar, Sezin Canbek, Melike Ozcelik   +4 more
doaj   +1 more source

Genetics supersedes epigenetics in colon cancer phenotype

, 2003
A CpG island DNA methylator phenotype has been postulated to explain silencing of the hMLH1 DNA mismatch repair gene in cancer of the microsatellite mutator phenotype.
Perucho, Manuel, Yamamoto, Fumiichiro, Dai, Yuichi, Dai, Tomoko, Yamashita, Kentaro   +4 more
core   +1 more source

Colorectal Cancer "Methylator Phenotype": Fact or Artifact?

Neoplasia: An International Journal for Oncology Research, 2005
It has been proposed that human colorectal tumors can be classified into two groups: one in which methylation is rare, and another with methylation of several loci associated with a "CpG island methylated phenotype (CIMP)," characterized by preferential ...
Charles Anacleto, Andréia M. Leopoldino, Benedito Rossi, Fernando A. Soares, Ademar Lopes, José Cláudio C. Rocha, Otávia Caballero, Anamaria A. Camargo, Andrew J.G. Simpson, Sérgio D.J. Pena   +9 more
doaj   +1 more source

The Evolution of Low Mutation Rates in Experimental Mutator Populations of Saccharomyces cerevisiae

, 2012
SummaryMutation is the source of both beneficial adaptive variation and deleterious genetic load, fueling the opposing selective forces than shape mutation rate evolution.
Leu, Jun-Yi, McDonald, Michael J., Chang, Shang-Lin, Hsieh, Yu-Ying, Yu, Yen-Hsin   +4 more
core   +1 more source

The mutator phenotype theory can explain the complex morphology and behaviour of cancers

, 2002
Almost all solid malignancies exhibit complex cytological and architectural abnormalities, which vary from cell to cell and area to area within the same tumour, and between tumours of the same type.
Bignold, L.
core   +1 more source

Point mutation instability (PIN) mutator phenotype as model for true back mutations seen in hereditary tyrosinemia type 1 – a hypothesis

, 2011
Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disorder affecting fumarylacetoacetate hydrolase (FAH), the last enzyme in the tyrosine catabolism pathway.
Pretorius, Pieter J., Etresia van Dyk, Van Dyk, Etresia, Pieter J. Pretorius   +3 more
core   +1 more source

Surveying the Human Genome for Genetic Markers Associated with the Mutator Phenotype and Chromosomal Instability

, 2016
Cancer is a genetic disease that develops as a result of the acquisition of stable somatic mutations. Many cancers are believed to acquire mutations at significantly increased rates, a state commonly referred to as the "mutator phenotype". In this study,
Lee, Timothy Mendel
core   +1 more source

Imatinib mesylate (STI571) prevents the mutator phenotype of Bcr-Abl in hematopoietic cell lines.

, 2004
Progression of CML from chronic phase to blast crisis is accompanied by accumulating genetic alterations. To analyze whether this abnormality can be prevented by inhibition of Bcr-Abl, we measured the frequency of spontaneous and irradiation-induced HPRT
van der Kuip, H;Moehring, A;Wohlbold, L;Miething, C;Duyster, J;Aulitzky, WE
core   +1 more source

Data from: Adaptation to parasites and costs of parasite resistance in mutator and non-mutator bacteria

, 2015
Parasitism creates selection for resistance mechanisms in host populations and is hypothesized to promote increased host evolvability. However, the influence of these traits on host evolution when parasites are no longer present is unclear.
Bergmiller, Tobias ; https://orcid.org/, Hall, Alex R., Bischofberger, Anna M., Wielgoss, Sébastien, Bergmiller, Tobias   +4 more
core   +1 more source