Results 91 to 100 of about 9,839 (200)

Quick creation and mapping of EMS‐induced maize kernel mutants identifies classical gene ZmBT1 and novel gene ZmTOP6A

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Maize (Zea mays L.) kernel mutants are valuable tools for investigating kernel development. In this study, we employed ethyl methanesulfonate (EMS) mutagenesis of pollen on five inbred lines, which displayed varying performance after treatment. Over 400 independent kernel mutants were generated, showing a wide range of defects in both type and
Haixiao Dong, Hao Chen, Yuan Jiang, Jingzhe Zhang, Chaoyue Wang, Zhili Sun, Shengzhong Su, Shipeng Li, Hongkui Liu, Xiaohui Shan, Yaping Yuan   +10 more
wiley   +1 more source

A Concept Using α‐Niche Evolution Within Bacterial Communities to Direct β‐Niche Evolution of Focal Species

Environmental Microbiology, Volume 28, Issue 3, March 2026.
There is a great need for approaches to control how species evolve in response to environmental changes, particularly in complex microbiomes. The feasibility is often met with scepticism due to the multitude of open questions and high dimensionality of community eco‐evolutionary dynamics.
Thomas Scheuerl, Damian W. Rivett
wiley   +1 more source

The Mutation, a Key Determinant of Phenotype in ADPKD [PDF]

Journal of the American Society of Nephrology, 2013
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic diseases (frequency 1:500–1000) and a classic dominant disease with a penetrance of practically 100%, if defined as the development of multiple bilateral cysts in a family member that inherits a ...
Peter C, Harris, Katharina, Hopp
openaire   +2 more sources

New Phenotypes of Potato Co-induced by Mismatch Repair Deficiency and Somatic Hybridization

Frontiers in Plant Science, 2019
As plants are sessile they need a very efficient system for repairing damage done by external or internal mutagens to their DNA. Mismatch repair (MMR) is one of the systems that maintain genome integrity and prevent homeologous recombination.
Elena Rakosy-Tican, Enikö Lörincz-Besenyei, Enikö Lörincz-Besenyei, Imola Molnár, Ramona Thieme, Frank Hartung, Thorben Sprink, Olga Antonova, Ivan Famelaer, Geert Angenon, Adriana Aurori   +10 more
doaj   +1 more source

The maize mitogen‐activated protein kinase kinase kinase gene ZmMAPKKK45 is associated with multiple disease resistance

New Phytologist, Volume 249, Issue 6, Page 3003-3020, March 2026.
Summary Southern leaf blight (SLB), caused by the necrotrophic fungus Cochliobolus heterostrophus, is a major foliar disease of maize (Zea mays) world‐wide. A genome‐wide association study was performed to dissect the genetic basis of SLB resistance in maize. Functional validation was performed using mutant and transgenic analyses.
Tao Zhong, Bode Olukolu, Yang Bian, Shang Xue, Randall J. Wisser, Peter S. Ojiambo, James B. Holland, Qin Yang, Peter Balint‐Kurti   +8 more
wiley   +1 more source

Intermediate Phenotypes of ATP1A3 Mutations: Phenotype–Genotype Correlations

Tremor and other hyperkinetic movements (New York, N.Y.), 2015
Background: ATP1A3-related disorders include rapid-onset dystonia–parkinsonism (RDP or DYT12), alternating hemiplegia of childhood (AHC), and CAPOS syndrome (Cerebellar ataxia, Areflexia, Pes cavus, Optic atrophy, and Sensorineural hearing loss). Case Report: We report two cases with intermediate forms between RDP and AHC.
Termsarasab, Pichet, Yang, Amy C., Frucht, Steven J.   +2 more
openaire   +4 more sources

Transient multifocal genomic crisis creating chromothriptic and non-chromothriptic rearrangements in prezygotic testicular germ cells

BMC Medical Genomics, 2019
Background The co-occurrence of multiple de novo copy number variations (CNVs) is a rare phenomenon in the human genome. Recently, an “organismal CNV mutator phenotype” has been reported to result in transient genomic instability introducing multiple de ...
Atsushi Hattori, Kohji Okamura, Yumiko Terada, Rika Tanaka, Yuko Katoh-Fukui, Yoichi Matsubara, Keiko Matsubara, Masayo Kagami, Reiko Horikawa, Maki Fukami   +9 more
doaj   +1 more source

Improved Longan Genome Assembly Reveals Insights Into Flowering Mechanisms

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1678-1696, March 2026.
ABSTRACT Longan is an exotic tropical fruit crop and exhibits off‐season flowering induced by potassium chlorate (KClO3), though the molecular mechanisms remain unclear. We assembled a high‐quality, 441.5 Mb genome of variety ‘Shixia’, with a contig N50 at 28.1 Mb, 29, 325 protein‐coding genes, 26 telomeres and 15 centromeres.
Guochun Zhao, Fan Jiang, Wenshun Hu, Jisen Zhang, Wen Wang, Siping Tu, Baiyu Wang, Qing Zhang, Jing Mei, Lianyu Lin, Yiying Qi, Xiuping Chen, Jianguo Li, Ray Ming, Shaoquan Zheng   +14 more
wiley   +1 more source

Genome‐wide analysis of somatic noncoding mutation patterns and mitochondrial heteroplasmic shift in type B1 and B2 thymomas

The Journal of Pathology, Volume 268, Issue 2, Page 135-149, February 2026.
Abstract Type B1 and B2 thymomas are lymphocyte‐rich malignant tumours with few somatic mutations in protein‐coding regions of the nuclear genome; nonetheless, noncoding regions remain uncharacterized. Here, we developed a method to isolate pure thymoma cells from lymphocyte‐rich tissues, and then performed genome‐wide deep sequencing. The total number
Kohei Fujikura, Isabel Correa, Susanne Heck, Kaoru Watanabe, Juliet King, Emma McLean, Susan Ndagire, Yoshihisa Takahashi, Masahiko Kuroda, Andrea Bille, Daisuke Nonaka   +10 more
wiley   +1 more source

Mutator phenotype in Msh2-deficient murine embryonic fibroblasts

, 1997
Embryonic fibroblast cell lines were established from mice deficient, heterozygous, or proficient for Msh2, one of the three known DNA mismatch repair genes involved in hereditary nonpolyposis colon cancer (HNPCC).
Meuth, Mark, Reitmair, Armin H., Hill, Richard P., Mak, Tak W., Benchimol, Samuel, Fishel, Richard, Ganesh, Anil, Jang, Anne, Peacock, James, Bristow, Robert G.; id_orcid, Risley, Robert, Wilson, Teresa   +11 more
core   +2 more sources