Results 161 to 170 of about 27,474 (197)

Expression status of MLH1 and MSH2 mismatch repair proteins in colorectal carcinoma

Egyptian Journal of Pathology, 2023
Colorectal carcinoma (CRC) is a main cause of morbidity and mortality worldwide. Lynch syndrome or hereditary nonpolyposis colorectal carcinoma is a cancer syndrome that accounts for 5–10% of cases of CRCs, and it is caused by a germline mutation ...
Said A-A Mohamed, Al-Sayed Mohammed Tealeb, N. R. Abd-Elhameed, Yasser M Eldowik   +3 more
semanticscholar   +1 more source

Hubungan antara Ekspresi Protein MMR (Mismatch Repair) MLH-1 dengan Status Metastasis Kelenjar Getah Bening pada Pasien Karsinoma Kolorektal di RS. Kariadi

Medica Arteriana (Med-Art)
Latar Belakang: Karsinoma kolorektal adalah tumor epitelial ganas dari usus besar dan rektum dengan insidensi dan tingkat mortalitas yang menduduki peringkat kedua di dunia berdasarkan data Global Cancer Observatory (GLOBOCAN) tahun 2020.
Ernestine Sutrisno, Hermawan Istiadi, Devi Listiana, Siti Amarwati, A. Prasetyo   +4 more
semanticscholar   +1 more source

Targeting SIRT2 induces MLH1 deficiency and boosts antitumor immunity in preclinical colorectal cancer models.

Science Translational Medicine
Low tumor mutation burden and an immunosuppressive tumor microenvironment (TME) of colorectal cancers (CRCs) contribute to resistance to immune-checkpoint inhibitors in patients.
Qianling Gao, Lanlan Yang, Shubiao Ye, Mingru Mai, Yiting Liu, Xuefei Jiang, Xingzhi Feng, Zihuan Yang   +7 more
semanticscholar   +1 more source

Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1

Molecular Medicine Reports
Cisplatin (DDP) is a key chemotherapeutic agent in the treatment of gastric cancer; however, its efficacy is often limited by chemoresistance, a notable challenge in clinical oncology.
Wujun Wei, Jiaxin Li, Jingjing Huang, Qi Jiang, Cheng Lin, Rentong Hu, Jiazhu Wei, Qiao Li, Guidan Xu, Zhengyi Chang   +9 more
semanticscholar   +1 more source

Development of a prime editor with improved editing efficiency in Arabidopsis

BMB Reports
Prime editing is widely used in many organisms to introduce site-specific sequence modifications such as base substitutions, insertions, and deletions in genomic DNA without generating double-strand breaks.
Yeong Yeop Jeong, C. Hong, Jun Hee Han, Sangsu Bae, P. Seo   +4 more
semanticscholar   +1 more source

Association of glutaminase expression with immune-suppressive tumor microenvironment, clinicopathologic features, and clinical outcomes in endometrial cancer

International Journal of Gynecological Cancer
Objective Increased glutamine metabolism by cancer cells via upregulation of the drug-targetable enzyme glutaminase may contribute to an immune-suppressive tumor microenvironment.
S. Asaka, Neha Verma, T. Yen, Jessica L Hicks, Hiro Nonogaki, Yao-An Shen, Jiaxin Hong, R. Asaka, Angelo M DeMarzo, Tian-Li Wang, I. Shih, Stéphanie Gaillard   +11 more
semanticscholar   +1 more source

Prime Editing of Vascular Endothelial Growth Factor Receptor 2 Attenuates Angiogenesis In Vitro

The CRISPR Journal
Vascular endothelial growth factor receptor (VEGFR)-2 is a key switch for angiogenesis, which is observed in various human diseases. In this study, a novel system for advanced prime editing (PE), termed PE6h, is developed, consisting of dual lentiviral ...
Gaoen Ma, Hui Qi, Hongwei Deng, Lijun Dong, Qing Zhang, Junkai Ma, Yanhui Yang, Xiaohe Yan, Yajian Duan, Hetian Lei   +9 more
semanticscholar   +1 more source

MLH1 Gene Expression in Peripheral Blood in Colon Cancer Patients and Their Association with Colon Cancer.

Journal of Visualized Experiments
MutL homolog 1 (MLH1) is a component of the heterodimeric complex MutLα that detects and fixes base-base mismatches and insertion/deletion loops caused by nucleotide misincorporation.
Jing Liu, Peng Peng Lu, Ya Jun Miao
semanticscholar   +1 more source

Effect of dihydrotestosterone fluctuation on mismatch repair gene mutL homolog 1 in prostate epithelial cells and its mechanism

, 2020
Bo Xue, Jianpeng Hu, Xiaofei Zhang, Y. Wan, Xuechao Xu, F. Cui   +5 more
semanticscholar   +1 more source

In vitro study of human mutL homolog 1 hypermethylation in inducing drug resistance of esophageal carcinoma

Irish Journal of Medical Science, 2017
Y. Cao, Yaoyong Chen, Y. Huang, Zhihong Liu, G. Li   +4 more
semanticscholar   +1 more source