Results 21 to 30 of about 226,831 (225)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Entangling flux qubits with a bipolar dynamic inductance

, 2004
We propose a scheme to implement variable coupling between two flux qubits using the screening current response of a dc Superconducting QUantum Interference Device (SQUID).
B. L. T. Plourde, C.-E. Wu, D. Vion, F. K. Wilhelm, F. K. Wilhelm, J. Clarke, J. R. Friedman, J. Zhang, John Clarke, K. B. Whaley, P. A. Reichardt, S. Linzen, T. Hime, T. L. Robertson   +13 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Spectroscopy on two coupled flux qubits

, 2003
We have performed spectroscopy measurements on two coupled flux qubits. The qubits are coupled inductively, which results in a $\sigma_1^z\sigma_2^z$ interaction.
A. C. J. ter Haar, C. J. P. M. Harmans, D. J. Griffith, F. G. Paauw, J. B. Majer, J. E. Mooij, M. A. Nielsen   +6 more
core   +1 more source

Signatures of exciton coupling in paired nanoemitters [PDF]

, 2013
An exciton formed by the delocalized electronic excitation of paired nanoemitters is interpreted in terms of the electromagnetic emission of the pair and their mutual coupling with a photodetector.
Agio M., Andrews D. L., Aouani H., Bakker R. M., Bharadwaj P., Biagioni P., Corkish R., Curto A. G., Daniels G. J., David L. Andrews, David S. Bradshaw, Devilez A., Evers J., Girard C., Girard C., Hettich C., Jack S. Ford, Kasha M., Kühn S., Lee K. G., Lee K. G., Mohammadi A., Novotny L., Novotny L., Pellegrini G., Rice E. M., Rice E. M., Ringler M., Rolly B., Schmid S. I., Schmid S. I., Shegai T., Vecchi G., Ward D. R.   +33 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

From coupled elementary units to the complexity of the glass transition

, 2010
Supercooled liquids display fascinating properties upon cooling such as the emergence of dynamic length scales. Different models strongly vary with respect to the choice of the elementary subsystems (CRR) as well as their mutual coupling.
Heuer, A., Rehwald, C., Rubner, O.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Evidence for two-electron processes in the mutual neutralization of O- with O+ and N+ at Subthermal Collision Energies

, 2018
We have measured total absolute cross sections for the Mutual Neutralization (MN) of O- with O+/N+. A fine resolution (of about 50 meV) in the kinetic energy spectra of the product neutral atoms allows unique identification of the atomic states ...
Cederquist, H., de Ruette, N., Dochain, A., Kaminska, M., Launoy, T., Nascimento, R. F., Schmidt, H. T., Stockett, M. H., Urbain, X., Vaeck, N.   +9 more
core   +1 more source