Results 71 to 80 of about 488,983 (281)

Mutual exclusivity analysis identifies oncogenic network modules

, 2011
Although individual tumors of the same clinical type have surprisingly diverse genomic alterations, these events tend to occur in a limited number of pathways, and alterations that affect the same pathway tend to not co-occur in the same patient.
Giovanni Ciriello, Nikolaus Schultz, Chris Sander, Ethan Cerami   +3 more
core   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Identification of Common Driver Gene Modules and Associations between Cancers through Integrated Network Analysis

Global Challenges, 2021
High‐throughput biological data has created an unprecedented opportunity for illuminating the mechanisms of tumor emergence and evolution. An important and challenging problem in deciphering cancers is to investigate the commonalities of driver genes and
Bo Gao, Yue Zhao, Yonghang Gao, Guojun Li, Ling‐Yun Wu   +4 more
doaj   +1 more source

Our mutual exclusivity (ME) test is more powerful than a permutation test, which was applied previously.

, 2014
A Example simulated mutual exclusivity pattern. B The ME test shows smaller p-values with growing number of genes in the patterns. On the contrary, the permutation test (with 1000 column-wise permutations) is less powerful for larger patterns.
Ewa Szczurek (543794), Niko Beerenwinkel (54419)   +1 more
core   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Pan-Cancer Analysis of Potential Synthetic Lethal Drug Targets Specific to Alterations in DNA Damage Response

Frontiers in Oncology, 2019
Alterations in DNA damage response (DDR) is one of the several hallmarks of cancer. Genomic instability resulting from a disrupted DDR mechanism is known to contribute to cancer progression, and are subjected to radiation, cytotoxic, or more recently ...
Shaoli Das, Kevin Camphausen, Uma Shankavaram   +2 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Exclusively Mutual

Performative Practices: Architecture and Engineering in the 21st Century, 2011
As individuals, institutions, and agencies stumble over each other creating new benchmarks for performance, speaking past one another along the way, the concept of performance becomes increasingly illusive – as does its implication in architectural practice. MECHANISTICALLY, it is a manner or quality of functioning.
openaire   +1 more source

Deep daxes: mutual exclusivity arises through both learning biases and pragmatic strategies in neural networks [PDF]

, 2020
Children’s tendency to associate novel words with novel referents has been taken to reflect a bias toward mutual exclusivity. This tendency may be advantageous both as (1) an ad-hoc referent selection heuristic to single out referents lacking a label and
Gulordava, Kristina, Brochhagen, Thomas, Boleda, Gemma   +2 more
core   +1 more source

Ancestry-associated co-alteration landscape of KRAS and EGFR-altered non-squamous NSCLC

npj Precision Oncology
Racial/ethnic disparities mar NSCLC care and treatment outcomes. While socioeconomic factors and access to healthcare are important drivers of NSCLC disparities, a deeper understanding of genetic ancestry-associated genomic landscapes can better inform ...
Saumya D. Sisoudiya, Armande Ang Houle, Tharu Fernando, Timothy R. Wilson, Jennifer L. Schutzman, Jessica Lee, Alexa Schrock, Ethan S. Sokol, Smruthy Sivakumar, Zhen Shi, Gaurav Pathria   +10 more
doaj   +1 more source