Results 71 to 80 of about 22,950 (304)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Agricultural insurance mechanisms through mutualism: the case of an agricultural cooperative
RAUSP: Revista de Administração da Universidade de São PauloThe aim of this article is to verify how the mutualism model is applied in cooperatives to mitigate risks. We conducted a single, holistic case study of an agribusiness cooperative in Paraná State.
Paulo Alberto Machinski +3 more
doaj +1 more source
Burrowing crabs weaken mutualism between foundation species
, 2018 Dataset for manuscript: Burrowing crabs weaken mutualism between foundation species - Ecosystems 2018. The dataset contains the data on the experiment and field survey carried out in 2014 and 2015.
Smolders, prof.dr. A.J.P. (Radboud University) +7 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Linking obligate mutualism models in an extended consumer-resource framework [PDF]
, 2018 A simple model of obligate mutualist populations is presented in an extended consumer-resource (ECR) framework to resolve some of the deficiencies of traditional models.
Norbury, J +5 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A keystone mutualism promotes resistance to invasion
, 2021 It is not uncommon for one or a few species, and their interactions, to have disproportionate effects on other species in ecological communities. Such keystone interactions might affect how communities respond to the invasion of non-native species by ...
Diego P. Vázquez +9 more
core +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Global Labour Journal, 2023 This article contributes an understanding of mutualism as a foundational element in emergent worker collectivism. We challenge mainstream institutionalist accounts in industrial relations, especially from the Global North, that downplay processes of ...
Gabriella Alberti, Simon Joyce
doaj